Clinical trials
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Enhancing Depression Detection in Primary Care: Insights from the e-mhGAP-IG App Trial
Understanding the Trial Results The trial tested an app designed to help doctors detect depression better in patients. It was conducted in Nepal and Nigeria, comparing traditional training with training using the app. What Worked? In Nepal, doctors using the app detected depression in 24% of patients after training, up from 0% before. In Nigeria, […] ➡️➡️➡️
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Efficacy of 1% Ibuprofen Gel for Reducing Bleaching Sensitivity in Dental Practice
Trial Results Explained The study tested a new 1% ibuprofen gel to see if it could help reduce sensitivity during in-office teeth whitening. Unfortunately, the results showed that the gel did not help with sensitivity or change the color of the teeth. What Worked: The gel did not affect the color change of the teeth. […] ➡️➡️➡️
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“Enhancing Post-Stroke Recovery: The Role of Intermittent Theta-Burst Stimulation in Treating Unilateral Neglect”
Understanding the Trial Results The study looked at a treatment called intermittent theta-burst stimulation (iTBS) for patients who have unilateral neglect (UN) after a stroke. UN means that patients may ignore one side of their body or space. Here’s what the results showed: What Worked: Patients who received iTBS showed significant improvements in tasks that […] ➡️➡️➡️
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Enhancing Direct Pulp Capping Success with Er: YAG Laser and Biodentine in Permanent Teeth
Trial Results Explained The study looked at three treatment methods for patients with permanent teeth that had decay and needed direct pulp capping (DPC). The methods were: Biodentine alone Er: YAG laser followed by Biodentine Er: YAG laser alone The main finding was that using the Er: YAG laser with Biodentine led to better results. […] ➡️➡️➡️
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Improving Dementia Diagnosis in Low-Income Countries: Effective Training for Primary Care Physicians
Understanding the Study Results This study focused on improving how doctors in Cuba detect dementia, especially in low- and middle-income countries (LMICs). Here’s what we found: What Worked: Doctors who received special training felt more confident and were better at diagnosing dementia. What Didn’t Work: The study did not address all barriers to diagnosis, such […] ➡️➡️➡️
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Probiotic Limosilactobacillus reuteri Enhances Non-Surgical Periodontal Therapy Outcomes in Stage III-IV Periodontitis
Understanding the Trial Results The study looked at how a probiotic called Limosilactobacillus reuteri, when combined with non-surgical periodontal therapy, affects patients with stage III-IV periodontitis. Here’s what they found: What Worked: Both the test group (with probiotics) and the control group (without probiotics) showed improvement in periodontal health. The test group had a notable […] ➡️➡️➡️
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Prophylactic Moxifloxacin with Anti-VEGF Injections: Enhancing Safety Against Endophthalmitis
Understanding the Trial Results The study looked at whether adding moxifloxacin, an antibiotic, during eye injections can prevent infections after treatment for conditions like cystoid macular edema and macular neovascularization. Here’s what they found: What Worked: Using moxifloxacin did not lead to any cases of infection (endophthalmitis) in the group that received it, while there […] ➡️➡️➡️
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Patient Reactions to Artificial Intelligence-Clinician Discrepancies: Web-Based Randomized Experiment
Understanding Patient Reactions to AI and Clinician Discrepancies As the use of artificial intelligence (AI) in medical imaging grows, radiologists are starting to use AI to help detect lung cancer earlier. However, when there is a disagreement between what the AI and the radiologist recommend, it can make patients doubt their radiologist’s expertise. Key Findings […] ➡️➡️➡️
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Acute Glucose Tolerance in Response to Lower- and Higher-Load Resistance Exercise in Postmenopausal Women: Contribution of Aerobic Capacity and Body Composition
Understanding Acute Glucose Tolerance in Postmenopausal Women This study explored how different types of resistance exercise affect glucose tolerance in postmenopausal women. It compared two exercise methods: heavy weights with low repetitions (HWLR) and lighter weights with higher repetitions (LWHR). Key Findings Both HWLR and LWHR exercises improved glucose tolerance after the workout. However, there […] ➡️➡️➡️
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Epicardial ablation in high-risk Brugada syndrome to prevent ventricular fibrillation: results from a randomized clinical trial
Study Overview This study focused on epicardial ablation for patients with Brugada syndrome (BrS), a condition that can lead to dangerous heart rhythms. The goal was to see if this treatment could help reduce the risk of ventricular fibrillation (VF), a serious heart issue. Study Design The research involved a randomized trial with two groups: […] ➡️➡️➡️
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Comparison of Therapeutic Outcomes Between Concomitant Therapy and Tailored Therapy for Helicobacter pylori: A Multicenter, Prospective, and Randomized Study
Background Helicobacter pylori (H. pylori) infections are common and can lead to serious stomach issues. A big problem is that many treatments are not working anymore because the bacteria have become resistant to clarithromycin, a common antibiotic. To address this, doctors are now recommending a different kind of treatment called concomitant therapy, especially in places […] ➡️➡️➡️
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Study protocol of short versus long-term levetiracetam in brain tumors (LIBRA): a phase 3 randomized controlled trial
Background Seizures are common in patients with brain tumors, affecting their daily lives and increasing healthcare costs. Levetiracetam is the most frequently prescribed medication to prevent seizures after brain surgery. Typically, patients take it for 2-3 years, but the actual need for such a long duration is unclear. This study aims to compare a shorter […] ➡️➡️➡️
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Development and validation of a nomogram to pediatric postoperative pulmonary complications following thoracic surgery
Background Children’s lungs are different from adults’, making them more prone to breathing problems after certain surgeries. This study aimed to create a tool (a nomogram) to help predict these issues in children undergoing thoracic surgery with one-lung ventilation. Methods We studied 361 children who had this type of surgery. They were split into two […] ➡️➡️➡️
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Computational modelling and neural correlates of reinforcement learning following three-week escitalopram: a double-blind, placebo-controlled semi-randomised study
Study Overview This study explored how a medication called escitalopram, which is often used to treat depression, affects learning from rewards and punishments. It involved 64 healthy volunteers who took either escitalopram or a placebo for three weeks. Key Findings Participants who took escitalopram showed less learning from punishments compared to those who took the […] ➡️➡️➡️
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Psychometric validation of the EORTC QLQ-OES18 in patients with advanced or metastatic esophageal squamous cell carcinoma
Abstract The EORTC QLQ-OES18 is a tool used to measure symptoms in patients with advanced esophageal squamous cell carcinoma (ESCC). This study looked closely at how well this tool works in a specific patient group. Methodology Data from a large clinical trial (RATIONALE 302) was analyzed. This trial compared a new treatment called tislelizumab to […] ➡️➡️➡️
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Effect of acarbose and vildagliptin on plasma trimethylamine N-oxide levels in patients with type 2 diabetes mellitus: a 6-month, two-arm randomized controlled trial
Study Overview This study examined how two medications, acarbose and vildagliptin, affect levels of a substance called trimethylamine N-oxide (TMAO) in overweight and obese patients with type 2 diabetes. TMAO is linked to diabetes and its complications. Study Design We conducted a randomized controlled trial with 100 participants who were newly diagnosed with type 2 […] ➡️➡️➡️
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Adjuvant nonavalent HPV vaccination in women treated for vulvar HSIL, a randomized placebo-controlled trial; VulVaccin study protocol
Background Every year, 45,000 women globally are diagnosed with vulvar cancer, which often arises from a precancerous stage called vulvar high-grade squamous intraepithelial lesions (vHSIL). This condition is linked to high-risk human papillomavirus (HPV). Over 30% of women experience vHSIL recurrence even after treatment, leading to serious physical and emotional challenges. Our study explores an […] ➡️➡️➡️
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Results of a Randomized Controlled Trial Examining the Efficacy of Intranasal Oxytocin to Enhance Alcohol Behavioral Couple Therapy
Study Overview This study looked at how effective intranasal oxytocin (40 IU) is when used with Alcohol Behavioral Couple Therapy (ABCT) for treating alcohol use disorder (AUD). It compared the effects of oxytocin to a placebo (saline). Trial Details The clinical trial lasted for 12 weeks and was conducted from 2018 to 2024. It was […] ➡️➡️➡️
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Efficacy of red ointment in wound cavity repair following non-puerperal mastitis debridement
Study Overview This study examines the effectiveness of red ointment, a common topical treatment in traditional Chinese medicine, for helping wounds heal after surgery for non-puerperal mastitis (NPM). Methods A clinical trial involved 88 patients with NPM. They were randomly placed into two groups. Both groups had surgery to clean their wounds: Treatment Group: Received […] ➡️➡️➡️
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Evaluating the concordance between BICLA and SRI4 in patients with systemic lupus erythematosus from the placebo arms of the EXPLORER and ATHOS trials
Study Overview This study looked at two important ways to measure how well treatments work for patients with systemic lupus erythematosus (SLE). These methods are called BICLA and SRI4. We wanted to see how often these methods agreed or disagreed when looking at patients who received standard care or a placebo in two clinical trials: […] ➡️➡️➡️
