Clinical trials
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseStudy of the pharmacokinetics of extended release sildenafil
Study of the Pharmacokinetics of Extended Release Sildenafil Purpose of the Study The study aimed to compare how the drug Vildegra, approved in Russia, behaves in the body compared to the original drug, Viagra. Materials and Methods The study was designed as a prospective, open-label trial involving healthy male volunteers. A total of 48 men, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseQuality of Life in Subcutaneous or Transvenous Implantable Cardioverter-Defibrillator Patients: A Secondary Analysis of the PRAETORIAN Trial
Quality of Life in Patients with Subcutaneous or Transvenous Implantable Cardioverter-Defibrillators Study Overview The subcutaneous implantable cardioverter-defibrillator (S-ICD) was designed to reduce complications linked to the transvenous version (TV-ICD). This study looks at how these two devices affect patients’ quality of life. Methodology In the PRAETORIAN trial, patients needing an implantable cardioverter-defibrillator were randomly assigned […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy of Terpinen-4-ol Combined With Eyelid Deep Cleaning for the Treatment of Demodex Blepharitis: A Randomized, Open-Label Trial
Efficacy of Terpinen-4-ol Combined With Eyelid Deep Cleaning for Demodex Blepharitis Purpose This study aimed to test how well a treatment using terpinen-4-ol (T4O) and eyelid deep cleaning works for Demodex blepharitis. Methods We conducted a trial with 40 patients diagnosed with Demodex blepharitis at the Cornea Specialty Clinic of Hankou Aier Eye Hospital. Participants […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseClinical evaluation of the efficacy of focused extracorporeal shock-wave therapy in patients with cervical spondylosis: A randomized control trial
Clinical Trial on Focused Extracorporeal Shock-Wave Therapy for Cervical Spondylosis Study Overview Extracorporeal Shock Wave Therapy (ESWT) is a modern physiotherapy treatment that helps with muscle and bone issues. This study specifically looked at how effective focused ESWT (fESWT) is for relieving pain and improving function in patients with cervical spondylosis, a neck condition. Study […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCare to Explain? AI Explanation Types Differentially Impact Chest Radiograph Diagnostic Performance and Physician Trust in AI
Understanding the Impact of AI Explanations on Radiology Study Overview This study explores how different types of AI explanations affect the ability of doctors to diagnose chest X-rays and their trust in AI. It aimed to find out if AI explanations help or hinder doctors in making decisions. Research Details The study was conducted from […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSurvival outcomes of population-wide colonoscopy screening: reanalysis of the NordICC data
Survival Outcomes of Colonoscopy Screening: Key Findings Background Colonoscopy is a common method used to screen for colorectal cancer, but strong evidence supporting its effectiveness is lacking. The NordICC trial, the first randomized study on colonoscopy screening, showed no clear benefits for the general population. However, some benefits were suggested for specific groups. This study […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffectiveness of low-load resistance training with blood flow restriction vs. conventional high-intensity resistance training in older people diagnosed with sarcopenia: a randomized controlled trial
Study Overview This study examined how effective low-load resistance training with blood flow restriction (LRT-BFR) is compared to conventional high-intensity resistance training (CRT) for older adults with sarcopenia. Key Findings Participants: 21 older adults (65 years and older) diagnosed with sarcopenia. Training Groups: LRT-BFR: 20%-30% of one-repetition maximum (1RM) CRT: 60%-70% of 1RM Duration: 12 […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Comparing standard- and low-dose CBCT in diagnosis and treatment decisions for impacted mandibular third molars: a non-inferiority randomised clinical study
Study Overview This study compares the effectiveness of standard-dose and low-dose cone-beam computed tomography (CBCT) in diagnosing and treating impacted mandibular third molars (M3Ms). Objective The goal was to see how well low-dose CBCT shows the mandibular canal (MC) and its closeness to M3Ms, and how this affects decisions made by dental professionals. Methods A […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA synbiotic mixture for the management of infantile colic: A randomized trial
A Synbiotic Mixture for Managing Infantile Colic Study Overview This study investigates the effectiveness of a synbiotic (Bactecal D Liquid) for infants experiencing colic, which is characterized by excessive crying and irritability. A total of 68 infants were involved in a randomized trial, where they received either one or two doses of the synbiotic daily […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseClinical efficacy observation of heat-sensitive moxibustion combined with intrapleural perfusion of cisplatin in treatment of malignant pleural effusion
Clinical Study on Moxibustion and Cisplatin for Malignant Pleural Effusion Objective The study aimed to assess the effectiveness of combining heat-sensitive moxibustion with intrapleural cisplatin infusion compared to cisplatin infusion alone in treating malignant pleural effusion (MPE). Methods Forty patients with MPE were randomly divided into two groups: an observation group (20 patients) and a […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseHand-Arm Bimanual Intensive Therapy Including Lower Extremities in Infants With Unilateral Cerebral Palsy: A Randomized Clinical Trial
Hand-Arm Bimanual Intensive Therapy for Infants with Unilateral Cerebral Palsy Study Overview This clinical trial aimed to find out if the Hand-Arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE) can help improve motor skills in infants with unilateral cerebral palsy (UCP). Why It Matters Identifying cerebral palsy early and using effective therapies can significantly enhance […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCorrelation of CTCAE and patient-reported breast radiation dermatitis symptom scores
Correlation of CTCAE and Patient-Reported Breast Radiation Dermatitis Symptoms Study Overview This study looks at how the CTCAE scale, used by doctors to grade radiation dermatitis (RD), relates to symptoms reported by patients. It examines the connection between CTCAE scores and patient experiences using two assessment tools: the Skin Symptom Assessment (SSA) and the Radiation-Induced […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEmbodied cognition driven Qigong: a cross-sectional study and a pilot randomized controlled trial on managing depression and preventing relapse in substance dependence
Embodied Cognition Driven Qigong: Managing Depression and Preventing Relapse in Substance Use Disorders Objective Substance use disorders (SUDs) are a major public health issue, with high relapse rates. This study aimed to explore factors that influence relapse and to test a Health Qigong intervention to help manage these issues. Methods We surveyed 398 male substance […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Immunogenicity of adalimumab reference product and adalimumab-adbm in patients with rheumatoid arthritis, Crohn’s disease and chronic plaque psoriasis: a pooled analysis of the VOLTAIRE trials
Immunogenicity of Adalimumab Reference Product vs. Adalimumab-adbm Study Overview This analysis looked at the immunogenicity of a biosimilar drug, adalimumab-adbm (Cyltezo), compared to the original adalimumab (Humira) in patients with rheumatoid arthritis, Crohn’s disease, and chronic plaque psoriasis. Study Details In the VOLTAIRE trials, researchers measured the presence of antidrug antibodies (ADAs) and neutralizing antibodies […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAccuracy of healthcare systems data for identifying cardiovascular outcomes after stroke due to intracerebral haemorrhage in the United Kingdom
Accuracy of Healthcare Data in Identifying Cardiovascular Outcomes After Stroke Background Healthcare systems data (HCSD) can make clinical trials more efficient, but their accuracy is not always clear. This study aimed to evaluate how accurate HCSD is for detecting outcomes in the RESTART trial, comparing it to follow-up questionnaires. Methods RESTART was a clinical trial […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffectiveness of flaxseed consumption and fasting mimicking diet on anthropometric measures, biochemical parameters, and hepatic features in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): a randomized controlled clinical trial
Effectiveness of Flaxseed and Fasting Mimicking Diet in Managing MASLD Study Overview This study explored how combining flaxseed and a fasting mimicking diet (FMD) affects patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). While both treatments have shown benefits individually, their combined effect was unclear. Study Design Conducted over 12 weeks, this randomized trial involved […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe Effect of High-Intensity Interval Training on Quality of Life and Incidence of Chemotherapy Side Effects in Women With Breast Cancer
The Effect of High-Intensity Interval Training on Quality of Life and Chemotherapy Side Effects in Women With Breast Cancer Study Overview This study focuses on how high-intensity interval training (HIIT) affects the quality of life and side effects of chemotherapy in women with breast cancer (BC). Women undergoing neoadjuvant chemotherapy (NAC) often face various symptoms […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSelective nociceptive modulation using a novel prototype of transcutaneous kilohertz high-frequency alternating current stimulation: a crossover double-blind randomized sham-controlled trial
Selective Nociceptive Modulation with Transcutaneous KHFAC Stimulation Background Kilohertz high-frequency alternating current (KHFAC) stimulation is a method that can block nerves quickly without causing harm. Previous studies have tested frequencies from 5 to 20 kHz in humans, but few devices are approved for higher frequencies. This study aims to evaluate a new device that can […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Effects of exercise and dietary interventions on asprosin, leptin, and lipid metabolism in males with abdominal obesity, a randomized controlled trial
Effects of Exercise and Diet on Abdominal Obesity Study Overview This study focused on how exercise and diet impact health markers in men with abdominal obesity. It involved 44 males, average age 34.7 years, who were divided into three groups: Exercise Group (EG): 16 participants did aerobic-resistance exercise for 6 weeks. Exercise + Diet Group […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Effectiveness of treatment for concussion-related convergence insufficiency: The CONCUSS study protocol for a randomized clinical trial
Effectiveness of Treatment for Concussion-Related Convergence Insufficiency: The CONCUSS Study Study Overview The CONCUSS study is a clinical trial that aims to compare two treatment approaches for concussion-related convergence insufficiency (CONC-CI). It will evaluate: Immediate Office-Based Vergence/Accommodative Therapy with Movement (OBVAM) Delayed OBVAM (starting six weeks later) The study will also explore how the timing […] ➡️➡️➡️