Clinical trials
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAssessment of two methods for detecting carious dentin: an in vitro study
Assessment of Carious Dentin Detection Methods Study Overview This study aimed to compare two methods for detecting carious dentin: Caries Finder and BlueCheck. We wanted to see if these methods work as well as the traditional visual and tactile methods. Study Method We used 65 extracted human teeth with specific lesions. The teeth were divided […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePredictors and Impact of Disclosure Efficacy Among Cancer Survivors
Predictors and Impact of Disclosure Efficacy Among Cancer Survivors Background Cancer survivors who talk about their diagnosis and experiences gain many benefits, including a better quality of life. Understanding what helps these survivors share their stories is important. One key factor is “disclosure efficacy,” which means feeling confident about sharing personal information. Aims In the […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseNeural Mechanism of Cognitive Reserve in Acupuncture Stimulation: Protocol for a Randomized, Placebo-Controlled Functional Near-Infrared Spectroscopy Trial
Neural Mechanism of Cognitive Reserve in Acupuncture Stimulation Study Overview This study focuses on understanding how acupuncture may help with cognitive reserve (CR) in aging and dementia. CR is the brain’s ability to cope with damage and is important for predicting dementia outcomes. Why This Study Matters Dementia currently has no cure, making early diagnosis […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy of Microneedle Fractional Radiofrequency Combined With Topical Insulin for the Treatment of Facial Atrophic Acne Scars: A Split-Face, Double-Blinded, Randomized, Placebo-Controlled Trial
Efficacy of Microneedle Fractional Radiofrequency Combined With Topical Insulin for Treating Acne Scars Study Overview This study explored how effective combining topical insulin (TI) with microneedle fractional radiofrequency (MFR) is for treating atrophic acne scars. Key Findings Improved Results: Participants showed significant improvement in scar volume after treatment. Effective Treatment: The combination of MFR and […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA randomised clinical trial comparing a surgical approach for treatment of peri-implantitis to non-surgical debridement with adjunctive diode laser therapy
A Randomised Clinical Trial on Peri-Implantitis Treatment Objective The study aimed to compare the effectiveness of non-surgical treatment with diode laser therapy to surgical methods for managing peri-implantitis. Materials and Methods Forty patients with peri-implantitis were divided into two groups: Test Group: Received mechanical cleaning and diode laser therapy on Days 0, 7, and 14. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe Impact of Listening to Music During MRI-Fusion Prostate Biopsy Procedures on Pain and Anxiety Levels: A Randomized Controlled Trial
The Impact of Listening to Music During MRI-Fusion Prostate Biopsy Procedures on Pain and Anxiety Levels Study Overview This study explores how listening to music during combined biopsy (CBx) procedures affects pain and anxiety levels in patients. CBx combines two types of biopsies for better diagnosis but can be more uncomfortable than traditional methods. Methods […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase30% Supramolecular Salicylic Acid Improved Symptoms and Skin Barrier in Papulopustular Rosacea
30% Supramolecular Salicylic Acid Improves Rosacea Symptoms Study Overview Rosacea is a common skin condition affecting many individuals globally. Managing this condition can be difficult for dermatologists. Study Purpose This study aimed to evaluate how effective and safe a 30% supramolecular salicylic acid (SSA) treatment is for papulopustular rosacea. The focus was on: Reducing skin […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Effect of remimazolam tosilate for injection (HR7056) versus sevoflurane on the incidence of postoperative delirium in older patients undergoing total hip arthroplasty: study protocol for a prospective, multicentre, two-arm, parallel-group, randomised controlled trial
Study Overview This study compares the effects of two sedatives, remimazolam tosilate and sevoflurane, on the occurrence of postoperative delirium (POD) in older patients undergoing total hip surgery. Why This Study Matters Postoperative delirium is a common issue after surgery, especially in older adults. It can lead to serious complications. Understanding which sedative may reduce […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Intraindividual crossover comparison of gadobenate dimeglumine-enhanced and gadoxetate disodium-enhanced MRI for characterizing focal liver lesions
Intraindividual Comparison of MRI Contrast Agents for Liver Lesions Study Overview This study compared two MRI contrast agents, gadobenate and gadoxetate, in assessing liver lesions in the same individuals. Methodology A total of 140 adults participated, undergoing two MRI scans within 7-14 days. One scan used gadobenate (0.05 mmol/kg) and the other used gadoxetate (0.025 […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseDigital Mental Health Screening, Feedback, and Referral System for Teens With Socially Complex Needs: Protocol for a Randomized Controlled Trial Integrating the Teen Assess, Check, and Heal System into Pediatric Primary Care
Digital Mental Health Screening for Teens: A New Approach Study Overview: This study focuses on improving mental health care for teens with complex needs through a digital system called the Teen Assess, Check, and Heal (TeACH) System. By integrating this system into pediatric primary care (PPC), we aim to enhance access and reduce barriers to […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Intravascular Imaging Predictors Associated With Cardiovascular Events After Complex PCIs
Intravascular Imaging and Cardiovascular Events After Complex PCIs Study Overview This study examines how intravascular imaging during percutaneous coronary interventions (PCIs) can lead to better outcomes for patients with complex coronary artery issues compared to traditional methods. However, the effects of poor imaging results, like stent underexpansion or malapposition, are not fully understood with modern […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Effect of Balloon Pulmonary Angioplasty and Riociguat on Right Ventricular Afterload and Function in CTEPH: Insights From the RACE Trial
Effect of Balloon Pulmonary Angioplasty and Riociguat on Right Ventricular Afterload and Function in CTEPH Introduction This study investigates how two treatments, riociguat and balloon pulmonary angioplasty (BPA), affect heart function in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH). Study Overview In a detailed analysis of the RACE trial, we looked at patients receiving […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
The Cancer Tracking System (CATSystem): Study protocol of a randomized control trial to evaluate a systems level intervention for cervical cancer screening, treatment, referral and follow up in Kenya
The Cancer Tracking System (CATSystem) Study Overview This study focuses on a new approach to improve cervical cancer screening and treatment in Kenya. Cervical cancer is preventable, but it remains a major health issue, especially in Sub-Saharan Africa. In Kenya, many women do not get screened, and those who do often do not follow up […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Performance of real-time polymerase chain reaction and Kato-Katz for diagnosing soil-transmitted helminth infections and evaluating treatment efficacy of emodepside in randomized controlled trials
Performance of Diagnostic Methods for Soil-Transmitted Helminth Infections Background The World Health Organization suggests using the Kato-Katz method, a simple and cost-effective test, to diagnose soil-transmitted helminth (STH) infections. However, this method can be subjective and less sensitive. In contrast, real-time polymerase chain reaction (qPCR) offers standardized results and higher sensitivity, making it a better […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Effect of Hospital-to-Home Transitional Care for COPD on Patient-Centered Outcomes
Effect of Hospital-to-Home Transitional Care for COPD on Patient-Centered Outcomes Background Transitional care from the hospital to home has been shown to improve healthcare use and health outcomes for patients with COPD. However, research on its impact on patient-centered outcomes, like symptoms and experiences, is limited. Study Overview This study was a single-blind randomized controlled […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEndotracheal Tube Cuff Inflation Methods in School-Age Children: Flow-Volume Loop-Guided Versus Stethoscope-Guided
Endotracheal Tube Cuff Inflation Methods in School-Age Children Study Overview This study compares two methods for inflating the cuffs of endotracheal tubes in children aged 4 to 12 years: the flow-volume loop guided technique and the stethoscope-guided technique. Key Findings Lower Pressure: The flow-volume loop guided method resulted in lower cuff pressure compared to the […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Chlorhexidine vs Routine Foot Washing to Prevent Diabetic Foot Ulcers: A Randomized Clinical Trial
Chlorhexidine vs Routine Foot Washing to Prevent Diabetic Foot Ulcers Study Overview This study aimed to find out if using chlorhexidine wipes daily is better than soap-and-water wipes for preventing foot complications in veterans with diabetes. Why This Matters Foot ulcers are a serious concern for people with diabetes. About 20% of these ulcers can […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
The role of community health workers in a collaborative care management intervention for cancer pain management: a feasibility study for a randomized controlled trial
The Role of Community Health Workers in Cancer Pain Management Study Overview This study explores how community health workers (CHWs) can help patients with cancer pain, especially those from rural areas or Hispanic/Latino backgrounds. Currently, few care models include CHWs, and this research aims to understand their potential role better. Study Purpose We wanted to […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
A Comparative Analytical Study of Functional and Esthetic Outcomes of Infraorbital and Subciliary Incisions to Assess the Redundancy of the Infraorbital Approach
A Comparative Study of Surgical Approaches for Infraorbital Fractures Objective This study compares two surgical methods to access the infraorbital area for treating fractures, focusing on both function and appearance after surgery. Methods We analyzed 22 patients over 18 months with zygomaticomaxillary complex (ZMC) fractures. Patients were divided into two groups: one for the subciliary […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Response in Patients With Persistent Pelvic Pain to Motor Imagery Through Auditory or Visual Input-A Pilot Randomized Trial
Response in Patients With Persistent Pelvic Pain to Motor Imagery Through Auditory or Visual Input – A Pilot Randomized Trial Study Overview This study looks at how patients with ongoing pelvic pain respond to a motor imagery treatment using either visual or auditory methods. We also examined how well patients can visualize mentally and how […] ➡️➡️➡️