Clinical trials
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePiano level laser therapy versus epidermal growth factor injection for painful myogenic temporomandibular disorder (a randomized clinical trial)
Laser Therapy vs. EGF Injection for Jaw Pain: A Clinical Trial Objective The goal of this study was to compare the effectiveness of Piano level laser therapy and epidermal growth factor (EGF) injection in relieving pain and improving function and quality of life for patients with myogenic temporomandibular disorder (TMD). Study Design We conducted a […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSupporting older people with cognitive impairment during and after hospital stays with intersectoral care management (intersec-CM)-results of a randomised clinical trial
Supporting Older People with Cognitive Impairment During and After Hospital Stays Background The shift from hospital to primary care can negatively affect older adults with cognitive impairment. Objective This study aimed to evaluate if intersectoral care management could reduce hospital readmissions and improve daily functioning in these individuals. Study Design This was a longitudinal study […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePhysical activity in people with borderline personality disorder: a study protocol for a randomised controlled trial.
Physical Activity in People with Borderline Personality Disorder Study Overview This study focuses on how physical activity (PA) can help individuals with borderline personality disorder (BPD). Current treatments like medication and therapy don’t always work effectively. This research aims to see if a PA program can improve symptoms and overall health in BPD patients. Study […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseIntranasal Insulin Diminishes Postoperative Delirium and Elevated Osteocalcin and Brain Derived Neurotrophic Factor in Older Patients Undergoing Joint Replacement: A Randomized, Double-Blind, Placebo-Controlled Trial
Intranasal Insulin Reduces Postoperative Delirium in Older Patients Study Overview This study explored how intranasal insulin affects older patients after joint replacement surgery. It aimed to see if this treatment could lower the chances and severity of postoperative delirium (POD) and improve insulin sensitivity markers. Key Findings Participants: 212 older patients (65 years and above) […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA novel description of AT deficiency in hospitalized COVID-19 patients
A Novel Description of Antithrombin Deficiency in Hospitalized COVID-19 Patients Objective Antithrombin (AT) helps reduce inflammation and blood clotting. We wanted to find out how common AT deficiency is in COVID-19 patients and if adding AT could help with blood clotting issues in these patients. Patients and Methods This study involved a randomized control trial. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSupporting primary care clinicians in caring for patients with alcohol use disorder: study protocol for Records for Alcohol Care Enhancement (RACE), a factorial four-arm randomized trial
Supporting Primary Care Clinicians in Alcohol Use Disorder Treatment Study Overview Alcohol use disorder (AUD) is a major cause of preventable deaths in the U.S. Many people with unhealthy alcohol use do not receive proper treatment. This study aims to see if additional support for primary care providers (PCPs) can improve treatment engagement for patients […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseOral lactoferrin as a treatment of pediatrics’ anemia resulted from chronic kidney diseases: a randomized controlled trial
Oral Lactoferrin for Treating Anemia in Children with Chronic Kidney Disease Study Overview Anemia in children often arises from chronic kidney disease (CKD), negatively impacting their health and well-being. Traditional treatments, like injectable iron, come with several side effects. Trial Details This clinical trial aimed to compare the effectiveness of oral lactoferrin versus intravenous (IV) […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseIsatuximab, bortezomib, lenalidomide, and limited dexamethasone in patients with transplant-ineligible multiple myeloma (REST): a multicentre, single-arm, phase 2 trial
Isatuximab, Bortezomib, Lenalidomide, and Limited Dexamethasone in Multiple Myeloma Treatment Overview of the Study This study explored the safety and effectiveness of isatuximab, bortezomib, lenalidomide, and limited dexamethasone for older patients with newly diagnosed multiple myeloma who are not eligible for stem cell transplants. Study Details Conducted between June 2021 and January 2023, the trial […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAficamten vs Metoprolol for Obstructive Hypertrophic Cardiomyopathy: MAPLE-HCM Rationale, Study Design, and Baseline Characteristics
Aficamten vs Metoprolol for Obstructive Hypertrophic Cardiomyopathy: MAPLE-HCM Overview Study Background Beta-blockers and certain calcium-channel blockers are the usual treatments for patients with symptomatic obstructive hypertrophic cardiomyopathy (oHCM). However, these medications do not address the root cause of the disease. Cardiac myosin inhibitors, like aficamten, work differently by reducing excessive heart muscle contractions. They have […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
An Incognito Standardized Patient Approach for Measuring and Reducing Intersectional Healthcare Stigma: A Pilot Cluster Randomized Control Trial
An Incognito Standardized Patient Approach for Measuring and Reducing Intersectional Healthcare Stigma Study Overview This study focused on how stigma affects healthcare access for people living with HIV (PLWH) and men who have sex with men (MSM). We tested a training program for healthcare providers aimed at reducing this stigma. Study Setting The research took […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseMetaverse Clinic for Pregnant Women With Subclinical Hypothyroidism: Prospective Randomized Study
Metaverse Clinic for Pregnant Women With Subclinical Hypothyroidism Study Overview This study explores the use of a metaverse platform to help pregnant women with subclinical hypothyroidism (SCH), a common thyroid issue that can lead to problems during pregnancy. Study Purpose The goal is to check if the metaverse can safely and effectively manage SCH in […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseStructure-Function Relationships in Geographic Atrophy Based on Mesopic Microperimetry, Fundus Autofluorescence, and Optical Coherence Tomography
Structure-Function Relationships in Geographic Atrophy Study Overview This study explores how retinal structure relates to visual function in geographic atrophy (GA). We focus on the connection between areas of vision loss (scotomas) and specific retinal features, particularly: Choroidal hypertransmission: A key sign of complete retinal pigment epithelium and outer retinal atrophy. Fundus autofluorescence (FAF): A […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Neurodevelopmental Outcomes After Nitric Oxide During Cardiopulmonary Bypass for Open Heart Surgery: A Randomized Clinical Trial
Neurodevelopmental Outcomes After Nitric Oxide During Cardiopulmonary Bypass for Open Heart Surgery Study Overview This study looked at how adding nitric oxide (NO) during heart surgery affects the brain development of infants with congenital heart defects. The goal was to see if NO could help reduce inflammation and improve recovery. Key Details Participants: 1364 infants […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCognitive Processing Therapy for Posttraumatic Stress Disorder in Japan: A Randomized Clinical Trial
Cognitive Processing Therapy for PTSD in Japan Overview Cognitive Processing Therapy (CPT) is a proven treatment for posttraumatic stress disorder (PTSD). This study focuses on its effectiveness in Japan, where such evidence is limited. Study Purpose The goal was to determine if CPT effectively treats PTSD in outpatient settings in Japan. Study Design This randomized […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Neuroimaging predictors of favorable outcomes after shunting procedures in patients with Hakim-Adams syndrome: a pilot prospective randomized trial
Neuroimaging Predictors of Successful Shunting in Hakim-Adams Syndrome Study Overview This study explores the effectiveness of cerebrospinal fluid shunting for patients with idiopathic normal pressure hydrocephalus. Over 15% of patients do not see improvement after surgery, prompting investigation into MRI predictors for better outcomes. Objective The goal was to compare a new MRI assessment model […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffectiveness of Attentional Bias Modification Combined With Cognitive Behavioral Therapy in Reducing Relapse Risk and Cravings in Male Patients With Alcohol Use Disorder: A Quasi-Randomized Controlled Trial
Effectiveness of Combined Therapy for Alcohol Use Disorder Study Overview This study explores how combining Attention Bias Modification (ABM) with Cognitive Behavioral Therapy (CBT) can help reduce relapse risk and cravings in men with Alcohol Use Disorder (AUD). Background AUD involves strong dependence on alcohol and difficulty controlling impulses. ABM helps individuals focus less on […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Comparison of the Effects of Vitagnus, Soy, and Vitagnus-soy Capsules on Premenstrual Syndrome in University Students: A Randomized Clinical Trial
Comparison of Vitagnus, Soy, and Vitagnus-Soy Capsules for Premenstrual Syndrome Background Premenstrual syndrome (PMS) affects many women and can lower their quality of life. This study looked at how effective Vitagnus, soy, and a combination of both are in treating PMS among university students. Methods This study was a triple-blind clinical trial involving 108 students […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Intermittent theta-burst stimulation with adjunctive D-cycloserine rapidly resolves suicidal ideation and decreases implicit association with death/suicide
Intermittent Theta-Burst Stimulation with D-Cycloserine: A New Hope for Suicidal Ideation Background Depressive disorders are common among people who die by suicide. Intermittent theta-burst stimulation (iTBS) is a noninvasive treatment for those struggling with hard-to-treat depression and at risk for suicide. Combining iTBS with D-cycloserine, a medication that enhances antidepressant effects, may offer better outcomes. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseUpadacitinib in active non-radiographic axial spondyloarthritis: 2-year data from the phase 3 SELECT-AXIS 2 study
Upadacitinib for Active Non-Radiographic Axial Spondyloarthritis: 2-Year Study Results Study Overview The SELECT-AXIS 2 study showed that upadacitinib significantly improved symptoms of active non-radiographic axial spondyloarthritis (nr-axSpA) over 52 weeks compared to a placebo. This report evaluates its effectiveness and safety over 2 years. Study Details Eligible adult patients with nr-axSpA were enrolled based on […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseYouth experiencing homelessness at risk for suicide: psychosocial risk factors and service use patterns
Youth Experiencing Homelessness at Risk for Suicide Study Overview This study looks at young adults who are homeless and at risk of suicide. It aims to understand their mental health challenges and how they use available services to help prevent suicide. Key Findings Out of 193 young adults studied, 126 (65.3%) were at low risk, […] ➡️➡️➡️