Clinical trials
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffects of tongue tamers and customized bonded spurs as an early treatment of anterior open bite: a randomized clinical study
Effects of Tongue Tamers and Customized Bonded Spurs for Anterior Open Bite Treatment Background Anterior open bite is a common issue for children that can affect their appearance, speech, eating, and emotional well-being. Early diagnosis and treatment are essential. Aim This study investigates how effective prefabricated metal-bonded tongue tamers and customized bonded spurs are for […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSupporting community translation of lung cancer screening: A web-based decision aid to support informed decision making
Supporting Community Lung Cancer Screening A web-based decision aid to help informed decision making Background The National Lung Screening Trial offers the promise of reducing lung cancer deaths. However, getting communities engaged in lung cancer screening (LCS) has been difficult. New policies encourage shared decision-making and using tools to help people make informed choices about […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseOlaparib as treatment for platinum-sensitive relapsed ovarian cancer by BRCA mutation and homologous recombination deficiency: Phase 2 LIGHT study final overall survival analysis
Olaparib for Ovarian Cancer Treatment: Key Findings from the LIGHT Study Background The LIGHT study evaluated the effectiveness of olaparib for patients with platinum-sensitive relapsed ovarian cancer (PSROC). Patients were grouped based on their BRCA mutation and homologous recombination deficiency (HRD) status. The study found that olaparib worked well in all groups, particularly in those […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCost-utility and cost-benefit analysis of a multi-component intervention (NEXpro) for neck-related symptoms in Swiss office workers
Cost-Utility and Cost-Benefit Analysis of NEXpro for Neck Pain in Office Workers Background Neck pain is a major health issue for office workers, affecting 42% to 68% of them. This study looked at the costs and benefits of a program called NEXpro, which includes neck exercises, health workshops, and ergonomic training over 12 weeks. Methods […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEight weeks of aerobic exercise, but not four, improves insulin sensitivity and cardiovascular performance in young women
Exercise Duration and Health Benefits for Young Women Study Overview This study investigates how different durations of aerobic exercise impact young women’s health, focusing on insulin sensitivity and cardiovascular performance. The key findings highlight the importance of exercising for eight weeks compared to just four weeks. Key Findings Duration Matters: Eight weeks of moderate-intensity aerobic […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe efficacy and safety of thymosin alpha1 for sepsis (TESTS): multicentre, double blinded, randomised, placebo controlled, phase 3 trial
The Efficacy and Safety of Thymosin Alpha1 for Sepsis (TESTS) Study Overview This study aimed to see if thymosin α1 can lower death rates in adults with sepsis. Study Design This was a phase 3 trial conducted at 22 centers in China from September 2016 to December 2020. It was double-blinded and placebo-controlled. Participants A […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseStudy of PEG-rhG-CSF for the prevention of neutropenia in concurrent chemoradiotherapy for nasopharyngeal carcinoma
Study on PEG-rhG-CSF for Preventing Neutropenia in Nasopharyngeal Carcinoma Background This study examines how effective and safe Polyethylene glycolated recombinant human granulocyte colony-stimulating factor (PEG-rhG-CSF) is in preventing neutropenia during concurrent chemoradiotherapy for nasopharyngeal carcinoma (NPC). Methods Conducted from June 1, 2021, to October 31, 2022, this single-center study involved patients with locally advanced NPC. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseLow-Intensity Online Intervention for Mental Distress Among Help-Seeking Young People in Hong Kong: A Randomized Clinical Trial
Low-Intensity Online Intervention for Mental Distress Among Young People in Hong Kong Study Overview This study looks at the mental health issues faced by young people in Hong Kong. Traditional therapy methods often struggle due to a lack of staff, time constraints, and low participation rates. Objective The goal was to assess how effective a […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePain control and analgesic requirements following laparoscopy-assisted transversus abdominus plane (TAP) block compared to port site infiltration post-paediatric laparoscopic appendicectomy. A Randomised controlled trial
Pain Control After Laparoscopic Appendicectomy in Children Study Overview This study compares two methods of pain control after laparoscopic appendicectomy in children: Laparoscopic-assisted Transversus Abdominus Plane block (L-TAP) and port site infiltration (PSI). It aims to find out which method is more effective in reducing pain and hospital stay. Key Findings Participants: 49 patients received […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseVedolizumab serum trough concentrations with and without thiopurines in ulcerative colitis: The prospective VIEWS pharmacokinetics study
Vedolizumab Study in Ulcerative Colitis Background Ulcerative colitis (UC) is a long-term inflammatory disease that needs ongoing treatment and monitoring. There is not much information about how vedolizumab works during maintenance therapy and how thiopurines affect its levels. Aim This study aimed to understand how vedolizumab levels relate to treatment outcomes and what happens when […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase18F-Prostate-Specific Membrane Antigen PET/CT imaging for potentially resectable pancreatic cancer (PANSCAN-2): a phase I/II study
18F-Prostate-Specific Membrane Antigen PET/CT Imaging for Pancreatic Cancer (PANSCAN-2) Study Overview This study explored the use of 18F-PSMA PET/CT imaging to detect potentially resectable pancreatic cancer, specifically pancreatic ductal adenocarcinoma (PDAC). Current imaging methods struggle to distinguish between cancerous and non-cancerous pancreatic conditions and often miss lymph node metastases. Study Details Seventeen patients with resectable […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseHome-use agents in the treatment of dentin hypersensitivity: clinical effectiveness evaluation with different measurement methods
Home-Use Agents for Dentin Hypersensitivity Treatment Study Overview This study evaluated how effective home-use desensitizing agents are over an 8-week period. Different measurement methods were used to compare their effectiveness. Research Details A clinical trial involved 180 participants aged 18 to 70 with diagnosed dentin hypersensitivity (DH). Out of these, 164 individuals met the criteria […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseElectronic Patient-Reported Outcome System Implementation in Outpatient Cardiovascular Care: A Randomized Clinical Trial
Electronic Patient-Reported Outcome System in Cardiovascular Care Importance Patient-reported outcomes (PRO) are important for cardiovascular care, but their use has faced significant challenges. Objective This study aimed to evaluate how an electronic PRO (ePRO) monitoring system can improve the quality of cardiovascular care. Study Overview This pilot randomized clinical trial took place in Japan from […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Effectiveness of potent topical corticosteroids versus mild ones in primary care for children with moderate flare-ups of atopic dermatitis; results of a randomised controlled trial
Effectiveness of Potent Topical Corticosteroids for Children with Atopic Dermatitis Study Overview This study evaluated how effective a strong topical corticosteroid (TCS) is compared to a mild one for treating moderate flare-ups of atopic dermatitis (AD) in children. The research was conducted in primary care settings. Study Details Design: Observational cohort study with a randomized […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseStudy protocol for Adaptive ChemoTherapy for Ovarian cancer (ACTOv): a multicentre phase II randomised controlled trial to evaluate the efficacy of adaptive therapy (AT) with carboplatin, based on changes in CA125, in patients with relapsed platinum-sensitive high-grade serous or high-grade endometrioid ovarian cancer
Study Overview: ACTOv Trial Title: Adaptive ChemoTherapy for Ovarian Cancer (ACTOv) This is a phase II study to test a new way of treating ovarian cancer using a drug called carboplatin. It focuses on women whose cancer has returned after treatment and is still sensitive to platinum-based therapies. What is Adaptive Therapy? Adaptive therapy (AT) […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Cost-effectiveness of metacognitive therapy for cardiac rehabilitation participants with symptoms of anxiety and/or depression: analysis of a randomised controlled trial
Cost-Effectiveness of Metacognitive Therapy for Cardiac Rehabilitation Study Overview The study examines the effectiveness and cost of metacognitive therapy (MCT) combined with usual care (UC) for patients with cardiovascular disease (CVD) experiencing anxiety and/or depression. The goal is to see if MCT is a better option than just UC. Research Method A multicenter, single-blind, randomized […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseImproving the accUracy of Referrals to the emerGency departmEnt of patieNts with chesT pain using the modified HEART score in Emergency Medical Transport (URGENT 2.0): protocol for a multicentre randomised controlled trial
Improving Emergency Department Referrals for Chest Pain: URGENT 2.0 Trial Overview Ischaemic heart disease is the leading cause of death globally. Identifying patients with serious heart issues during prehospital care for chest pain is often difficult for doctors and paramedics. Less than 20% of chest pain patients sent to the emergency department (ED) actually have […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseImpact of alternative diagnostic labels for melanoma in situ on management choices and psychological outcomes: protocol for an online randomised study
Impact of Alternative Diagnostic Labels for Melanoma In Situ Introduction Melanoma in situ has a low risk for life and health. However, current names make it hard for patients to understand the risks compared to more serious melanomas. This study will test if using different names affects patient decisions and anxiety. Study Methods This study […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseRandomised, placebo-controlled, double-blinded, four-way crossover trial to demonstrate the comparative pharmacodynamic equivalence of a non-invasive diagnostic test for adrenal insufficiency in a healthy population: the STARLIT-2 study protocol
STARLIT-2 Study Overview Introduction Cortisol is a vital hormone for managing stress. When the body fails to produce enough cortisol, it leads to a condition called adrenal insufficiency (AI), which can be life-threatening. The current test for diagnosing AI, the Short Synacthen Test (SST), is invasive and costly. There is a need for a non-invasive […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
A phase II double-blind multicentre, placebo-controlled trial to assess the efficacy and safety of alpelisib (BYL719) in paediatric and adult patients with Megalencephaly-CApillary malformation Polymicrogyria syndrome (MCAP): the SESAM study protocol
A Phase II Clinical Trial for MCAP Syndrome: The SESAM Study Introduction Megalencephaly capillary malformation polymicrogyria (MCAP syndrome) is caused by specific genetic changes. Key symptoms include large head size, growth issues, developmental delays, and brain abnormalities. Alpelisib (Vijoice) is a new treatment approved for related conditions. This study aims to see how effective alpelisib […] ➡️➡️➡️