Clinical trials
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseNutritional Counseling Based on Mindful Eating for the Eating Behavior of People Living with Overweight and Obesity: A Randomized Clinical Trial
Nutritional Counseling Based on Mindful Eating for Overweight and Obesity Study Overview This study looked at how Mindful Eating counseling affects the eating habits of people with overweight and obesity. Study Details Duration: 16 weeks Participants: 61 volunteers aged 18 or older with a BMI ≥ 25 kg/m² Groups: Participants were divided into two groups: […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffects of Zinc-Biofortified Wheat Intake on Plasma Markers of Fatty Acid Metabolism and Oxidative Stress Among Adolescents
Effects of Zinc-Biofortified Wheat Intake on Fatty Acid Metabolism and Oxidative Stress in Adolescents Background and Objective Zinc deficiency is a widespread issue that can hinder growth, immune function, and recovery from infections. It is also linked to non-communicable diseases. To tackle this problem, biofortifying wheat with zinc is proposed as a sustainable method to […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseManagement of Ventilator-Associated Pneumonia Caused by Pseudomonas and Acinetobacter Organisms in a Pediatric Center: A Randomized Controlled Study
Management of Ventilator-Associated Pneumonia in Pediatric Patients Overview Ventilator-associated pneumonia (VAP) is a serious hospital-acquired infection that often involves drug-resistant bacteria. It significantly impacts patients in intensive care units, leading to illness and even death. Study Purpose This research aimed to find the best antibiotic treatment to control VAP and improve patient recovery. We used […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseDiagnosis of Pain Deception Using Minnesota Multiphasic Personality Inventory-2 Based on XGBoost Machine Learning Algorithm: A Single-Blinded Randomized Controlled Trial
Diagnosis of Pain Deception Using Machine Learning Study Overview This study aimed to improve the diagnosis of pain deception, a complex issue due to its subjective nature. We utilized the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) alongside a machine learning (ML) method called XGBoost to assess its effectiveness. Study Design We conducted a single-blinded, randomized controlled […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSuperior efficacy of intramuscular diclofenac compared to intravenous tramadol for acute renal colic in northern Thai patients: A randomised double-blind, sham-controlled trial
Study Overview This study compares the effectiveness of intramuscular diclofenac and intravenous tramadol for relieving pain in patients with acute renal colic in northern Thailand. Objective The goal was to see which medication provided faster pain relief: 75 mg of diclofenac given by injection or 50 mg of tramadol given through an IV. Methods The […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseOverground robotic exoskeleton vs conventional therapy in inpatient stroke rehabilitation: results from a pragmatic, multicentre implementation programme
Overground Robotic Exoskeleton vs Conventional Therapy in Stroke Rehabilitation Study Overview This study compares the effectiveness of an overground robotic exoskeleton (ORE) to traditional therapy in helping stroke patients recover mobility. The research was part of the IMOVE program, which included multiple centers and allowed participants to choose between 12 sessions of ORE or standard […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseLong-term neuropsychologic outcome of pre-emptive mTOR inhibitor treatment in children with tuberous sclerosis complex (TSC) under 4 months of age (PROTECT), a two-arm, randomized, observer-blind, controlled phase IIb national multicentre clinical trial: study protocol
Study Overview Long-term Neuropsychologic Outcomes in Children with Tuberous Sclerosis Complex This clinical trial focuses on the effects of mTOR inhibitors in young children diagnosed with tuberous sclerosis complex (TSC) before they are four months old. It is a two-arm, randomized, observer-blind study conducted across multiple centers in Germany. Background TSC is a genetic disorder […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCessation of thumb/finger sucking habit in children using electronic habit reminder versus palatal crib: a randomized clinical pilot study
Study on Stopping Thumb/Finger Sucking in Children Overview This study compares two methods to help children stop thumb or finger sucking: an electronic habit reminder and a palatal crib. The study took place over 9 months and included children aged 6 to 14 with this habit that caused dental issues. Methods We randomly assigned 22 […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAssociation between resolution of MRI-detected inflammation and improved clinical outcomes in axial spondyloarthritis under long-term anti-TNF therapy
Study Overview This study examines the link between MRI-detected inflammation and clinical outcomes in patients with axial spondyloarthritis (axSpA) receiving long-term treatment with the TNF inhibitor etanercept. Objectives We aimed to understand how inflammation seen on MRI relates to achieving low disease activity or inactive disease in axSpA patients over time. Methods We analyzed data […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Cardiac arrhythmia assessment with patch electrocardiogram versus insertable cardiac monitor: a cohort study in endurance athletes with atrial fibrillation
Cardiac Arrhythmia Assessment in Endurance Athletes Study Overview This study compared two methods for tracking heart rhythm in endurance athletes with atrial fibrillation (AF). It aimed to evaluate how well a patch electrocardiogram (ECG) detects heart issues compared to a more established insertable cardiac monitor. Study Design It was a prospective cohort study involving endurance […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseLebrikizumab is associated with improvements in patient-reported symptoms and quality-of-life measures across Eczema Area and Severity Index response categories: pooled results from phase-3 randomized ADvocate1 and ADvocate2 studies in patients with moderate-to-severe atopic dermatitis
Lebrikizumab Improves Symptoms and Quality of Life in Atopic Dermatitis Study Overview Lebrikizumab is a treatment that has shown significant improvements in patients with moderate-to-severe atopic dermatitis (AD) based on results from the phase 3 Advocate1 and Advocate2 studies. Key Findings Improved Symptoms: Patients receiving lebrikizumab experienced notable improvements in their AD symptoms. Quality of […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Effect of power training on function and body composition in older women with probable sarcopenia. A study protocol for a randomized controlled trial
Impact of Power Training on Older Women with Sarcopenia Study Overview This study aims to evaluate how power training (PT) affects body composition and functionality in women over 65 years old who are at risk of sarcopenia, a condition marked by muscle loss and weakness. Background Sarcopenia often occurs due to hormonal changes in older […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAtezolizumab plus bevacizumab in patients with unresectable or metastatic mucosal melanoma: 3-year survival update and multi-omics analysis
Atezolizumab and Bevacizumab for Mucosal Melanoma: Key Findings Background Atezolizumab combined with bevacizumab has shown promising results for patients with advanced mucosal melanoma. This report updates the survival rates over three years and analyzes data to find markers that predict treatment responses. Methods Forty-three patients received atezolizumab and bevacizumab through intravenous infusion every three weeks. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseRight ventricular strain impairment due to hypoxia in patients with COPD: a post hoc analysis of two randomised controlled trials
Right Ventricular Strain Impairment Due to Hypoxia in COPD Patients Study Overview This study looks at how low oxygen levels affect the right side of the heart in patients with Chronic Obstructive Pulmonary Disease (COPD). We analyzed data from two clinical trials to understand the impact of high altitude on heart function. Key Findings Background: […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseBrain radiotherapy combined with camrelizumab and platinum-doublet chemotherapy for previously untreated advanced non-small-cell lung cancer with brain metastases (C-Brain): a multicentre, single-arm, phase 2 trial
Brain Radiotherapy with Camrelizumab and Platinum-Doublet Chemotherapy for NSCLC Study Overview This study examines the effectiveness and safety of combining brain radiotherapy with camrelizumab and chemotherapy for patients with advanced non-small-cell lung cancer (NSCLC) that has spread to the brain. Key Points Background: Patients with NSCLC and brain metastases often face limited treatment options and […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseDiabe-teach: a randomized controlled trial of a gamified approach to enhance medical undergraduates’ knowledge and comprehension of diabetes mellitus
Diabe-teach: An Innovative Game to Improve Diabetes Knowledge in Medical Students The rise of diabetes worldwide makes it essential for medical students to understand this disease thoroughly for better diagnosis and management. Why Traditional Teaching Methods Fall Short Standard teaching methods often miss interactive elements that help students engage and remember information effectively. Study Overview […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseDeeper response predicts better outcomes in high-risk-smoldering-myeloma: results of the I-PRISM phase II clinical trial
Improved Outcomes in High-Risk Smoldering Myeloma: I-PRISM Phase II Trial Results Key Findings The I-PRISM phase II clinical trial studied the effects of ixazomib, lenalidomide, and dexamethasone on 55 patients with high-risk smoldering multiple myeloma (HR-SMM). Here are the main results: Progression-Free Survival (PFS): The median PFS was not reached after 50 months of follow-up. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
The effects of dietary protein on physical performance and body composition in middle age and older people having type II diabetes mellitus: a randomized pilot study
The Effects of Dietary Protein on Physical Performance in Older Adults with Type 2 Diabetes Study Overview This study looked at how increasing dietary protein can help older adults with type 2 diabetes. The goal was to see if more protein can improve muscle mass, strength, and physical performance. Study Method In a 12-week study, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseMetastatic sites of baseline as predictors in recurrent or metastatic nasopharyngeal carinoma treated with PD-L1 inhibitor: a secondary analysis of multicenter, single-arm, phase II study (KL-A167)
Study Overview This study examines how the location of metastatic sites affects the treatment outcomes of recurrent or metastatic nasopharyngeal carcinoma (R/M NPC) patients receiving a PD-L1 inhibitor called KL-A167. Key Findings Patient Demographics: 153 patients were studied, with an average age of 47 years; 81% were male. Metastatic Sites: Most patients had distant metastasis, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseClinical Manifestations
Clinical Manifestations Study Overview This study looked at how well computerized cognitive training (CCT) works when combined with selective serotonin reuptake inhibitors (SSRIs) for patients with late-life depression (LLD). Method The research took place from May 5, 2021, to April 21, 2023. Patients diagnosed with major depressive disorder were divided into two groups: CCT and […] ➡️➡️➡️