Study Title: Comparison of Intramyocellular Lipid Metabolism
Published in: Nat Commun. 2024 May 15;15(1):3690
Summary: The study compared intramyocellular lipid metabolism in male endurance athletes and patients with type 2 diabetes. Despite differences in insulin sensitivity and cardiometabolic risk, both groups showed increased skeletal myocyte fat storage, known as the “athlete’s paradox.”
Method: The study involved 29 male endurance athletes and 30 patients with diabetes. The participants underwent deconditioning or endurance training, and their skeletal myocyte lipid signature was characterized and compared.
Findings: Athletes exhibited higher intramyocellular fat saturation with very high palmitate kinetics, which was reduced by deconditioning. In contrast, patients with type 2 diabetes showed higher unsaturated intramyocellular fat and blunted palmitate and linoleate kinetics. However, after endurance training, the lipid profiles of the diabetes patients aligned with those of deconditioned athletes. Endurance training was associated with improved insulin sensitivity, serum cholesterol/triglycerides, glycaemic control, physical performance, post-insulin receptor pathway signaling, and metabolic sensing.
Conclusion: The study concluded that insulin-resistant, maladapted intramyocellular lipid storage and turnover in patients with type 2 diabetes can be reversed through endurance training, leading to increased contributions of the saturated intramyocellular fatty acid pools.
Clinical Trial Registration: NCT03065140: Muscle Fat Compartments and Turnover as Determinant of Insulin Sensitivity (MISTY)
Practical Solutions: Clinical trials play a crucial role in developing safe and effective treatments. Our AI-driven platform, DocSym, consolidates ICD-11 standards, clinical protocols, and research into an easily accessible knowledge base for clinicians. Additionally, our mobile apps support scheduling, monitoring treatments, and telemedicine, streamlining operations and expanding services digitally.
Value: By leveraging AI, clinics can enhance their workflows, improve patient outcomes, and reduce paper routines. To learn more about how we can help, visit aidevmd.com.
