Non-specific uptake of (18)F-FAPI-04 in the pancreas and its related factors: a post-hoc analysis of an ongoing prospective clinical trial

Non-specific Uptake of 18F-FAPI-04 in the Pancreas: Practical Solutions and Value

Key Findings:

This study analyzed the non-specific uptake (NSU) of 18F-FAPI in the pancreas and identified related factors. The NSU group showed higher uptake of 18F-FAPI and 18F-FDG, and was associated with a history of drinking, chronic liver diseases, and gastrectomy.

Practical Solutions:

Identified cutoff values for 18F-FAPI and 18F-FDG can help in identifying NSU. Correlations were found between 18F-FAPI uptake and blood cell analysis, liver function indexes, and inflammatory indices, providing potential markers for NSU prediction.

Value:

This study highlights the value of 18F-FAPI-PET/CT in predicting pancreatic NSU and its association with specific medical history and laboratory indices.

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