Objective
This clinical study looked at how well an experimental pregabalin (PG) gel can reduce dental sensitivity (DS) and color change after teeth whitening.
Study Details
Seventy-five volunteers participated and were divided into three groups:
- GPG: 10% pregabalin gel
- GKF: 5% potassium nitrate and 2% sodium fluoride
- GP: Placebo gel
Before the whitening treatment, the GPG and GKF groups applied their gels for 10 minutes. The GP group used a placebo gel. The whitening was done using 35% hydrogen peroxide over three sessions, with a week between each session. We measured dental sensitivity for 21 days after treatment and assessed color changes before and a week after the last session.
Results
Analysis showed that:
- On days 1, 8, and 15, the GP group reported higher sensitivity compared to the other groups.
- There was no significant difference in sensitivity between the GKF and GPG groups.
- The GP group had a notable increase in sensitivity by day 15.
Conclusions
The 10% pregabalin gel effectively reduced dental sensitivity without affecting the whitening results.
Clinical Significance
Using 10% pregabalin gel and potassium nitrate fluoride can help reduce tooth sensitivity 24 hours after whitening with 35% hydrogen peroxide.
Next Steps for Clinics and Patients
Define Measurable Outcomes
Set clear goals to track the effectiveness of the pregabalin gel in reducing sensitivity and improving patient comfort during teeth whitening.
Select AI Tools
Choose AI solutions that can assist in monitoring and improving clinical outcomes based on the trial results.
Implement Step by Step
Start with a pilot project to track results using AI solutions, ensuring to measure the real-world impact of the pregabalin gel.
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