Effect of long-term Mediterranean versus low-fat diet on neutrophil count, and type 2 diabetes mellitus remission in patients with coronary heart disease: results from the CORDIOPREV study

Background

Recent studies show that diet and exercise can help people with type 2 diabetes (T2DM) improve their health. This research also suggests that the immune system may play an important role in this process.

Study Overview

This study looked at 183 newly diagnosed T2DM patients who were not on any glucose-lowering medications. They were divided into two groups: one followed a Mediterranean diet, and the other followed a low-fat diet. After five years, the patients were categorized as either Responders (those who achieved T2DM remission) or Non-Responders (those who did not).

Key Findings

The study found that patients with a lower neutrophil count at the start were more likely to achieve T2DM remission if they followed the Mediterranean diet. Specifically, those in the lowest neutrophil group had a four times higher chance of remission compared to those in the highest group.

Responders also showed a significant decrease in neutrophil count over five years and improved insulin sensitivity, which is crucial for managing diabetes.

Practical Healthcare Results

These findings suggest that measuring neutrophil counts can help identify patients who are more likely to benefit from a Mediterranean diet in managing their T2DM. This could lead to better treatment plans and improved patient outcomes.

Next Steps for Clinics and Patients

Clinics should focus on:

  • Setting clear goals for diet interventions based on neutrophil counts.
  • Implementing tailored AI solutions to track patient progress and outcomes.
  • Starting pilot projects to evaluate the effectiveness of dietary changes in real-world settings.

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