Efficacy of ETB-F01, Heat-Killed Akkermansia muciniphila Strain EB-AMDK19, in Patients with Respiratory Symptoms: A Multicenter Clinical Trial

Efficacy of ETB-F01 in Patients with Respiratory Symptoms

Study Overview

Respiratory issues are common and can lead to serious health problems. This study focuses on a treatment called ETB-F01, which contains heat-killed Akkermansia muciniphila strain EB-AMDK19. We wanted to see if it helps reduce respiratory symptoms.

Trial Details

This was a randomized, double-blind trial involving participants with respiratory symptoms. They were treated with ETB-F01 or a placebo for 4 to 12 weeks. We measured:

  • Breathlessness, Cough, and Sputum Scale (BCSS)
  • Lung function
  • Other respiratory-related questionnaires

Results

In the group that received ETB-F01:

  • BCSS total scores improved significantly compared to the placebo group.
  • Specifically, there was a notable reduction in breathlessness and cough.
  • While lung function showed some improvement, it wasn’t statistically significant.
  • No serious side effects were reported from ETB-F01.

Conclusion

ETB-F01 is safe and effective for reducing respiratory symptoms, providing a practical solution for patients.

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