Healing Potential of Blood Clot, S-PRF, and A-PRF in Treating Non-Vital Teeth
Overview
This study explored how effective different regenerative treatments are for treating necrotic mature teeth with chronic periapical periodontitis over 18 months.
Study Details
We included 51 adult participants with single-rooted teeth affected by chronic periapical periodontitis. They were divided into three groups of 17. All groups received the same initial treatment. After two weeks, they underwent regenerative therapy using:
- Blood clot technique
- Standard-PRF (S-PRF)
- Advanced-PRF (A-PRF)
Follow-up evaluations were conducted at 6, 12, and 18 months to assess outcomes.
Results
At 18 months, the success rates were:
- Blood group: 58.8%
- S-PRF group: 94.1%
- A-PRF group: 76.5%
Clinical success rates were:
- Blood group: 82.4%
- S-PRF and A-PRF groups: 88.2%
Overall success, combining clinical and radiographic results, was 76.5%. Sensitivity gained after 12 and 18 months was noted as follows:
- A-PRF group: 29.4%
- S-PRF group: 41.2%
- Blood clot group: 17.6%
Conclusion
PRF-based regenerative techniques may be more effective than blood clot methods for treating non-vital teeth with chronic periapical periodontitis. Further clinical studies are needed for more in-depth evaluations.
Clinical Trial Registration
This study is registered on ClinicalTrials.gov (ID: NCT04606719) since October 28, 2020.
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