Kinetic Profiling of RAS Mutations in Metastatic Colorectal Cancer
Study Overview
Researchers tracked RAS mutation status in metastatic colorectal cancer patients over time using circulating tumor DNA (ctDNA) sequencing during the CO.26 trial, which assessed durvalumab + tremelimumab treatment in heavily pretreated patients.
Key Findings
Among the patients with RAS mutations, a small percentage (3.2%-6.3%) showed transient loss of RAS mutations in ctDNA, with most cases (67%) experiencing subsequent re-emergence of the mutations.
Patients with transient RAS mutation disappearance had a lower likelihood of having multiple lesions at trial baseline compared to those with persistent RAS mutations.
Clinical Implications
The study highlights the transient nature of the neo-RAS-WT phenomenon in a subset of metastatic colorectal cancer patients, shedding light on the complexity of RAS mutation dynamics in this context.
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