Imetelstat is a new drug that targets telomerase, an enzyme linked to cancer. Researchers wanted to see if it affects heart health, especially the risk of heart rhythm problems.
The study included both laboratory tests and tests on animals and patients.
1. **In the lab:**
– Imetelstat was tested in cells to see if it affects a specific heart channel (hERG).
– It showed no harmful effects even at high doses.
2. **In animals:**
– Monkeys received different doses of imetelstat.
– Their heart health was monitored before and after the drug was given.
– No heart issues were found.
3. **In patients:**
– Patients with a blood condition received imetelstat every four weeks.
– Their heart rhythms were closely monitored through electrocardiograms (ECGs).
– Results showed no significant heart rhythm changes.
– Imetelstat did not affect heart rhythm in lab tests or animal studies.
– In patients, the drug showed no significant impact on heart health.
– Overall, imetelstat has a low risk of causing heart rhythm problems.
- Imetelstat is safe for heart health.
- No significant heart rhythm issues were found in studies.
- Further research can help improve patient care.
Doctors can consider using imetelstat for patients with specific conditions while monitoring heart health. Patients should discuss any concerns with their healthcare providers to ensure safe treatment.
