Relationship between NT-proBNP, Echocardiographic Abnormalities and Functional Status in Patients with Subclinical Diabetic Cardiomyopathy
Introduction
Diabetes can lead to heart muscle disease (cardiomyopathy) through different mechanisms. The connection between natriuretic peptides, heart structure issues, and functional abilities in diabetic cardiomyopathy (DbCM) patients is not well understood.
Methods
In this study, 685 patients with asymptomatic DbCM from the ARISE-HF trial underwent tests including echocardiography, lab work, and functional assessments. The participants were grouped by their NT-proBNP levels, and the relationship between NT-proBNP, echocardiographic parameters, and functional measures was analyzed.
Results
The study found that elevated NT-proBNP levels were not linked to specific heart structural issues. However, these elevated levels were associated with lower health status, reduced activity levels, and diminished functional capacity in these patients.
Conclusion
Despite the absence of specific heart structural issues, high NT-proBNP levels were associated with decreased functional capacity in patients with subclinical DbCM. These findings suggest that biomarker concentrations reflect a decline in functional capacity, even when heart structure appears normal.
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