Clinical research

Clinical Effect of MB-PDT Assisted Initial Therapy on Alveolar Angle Absorption of Lower Anterior Teeth Abstract Purpose: To assess the impact of MB-PDT assisted essential therapy on angle resorption of lower anterior alveolar bone in patients with periodontitis. Methods: Forty patients with periodontitis stage III-IV or C, lower anterior teeth alveolar bone angle resorption, and periodontal pocket depth greater than 4 mm were selected. They were divided into control and experimental groups. The experimental group received MB-PDT in addition to essential treatment. Various indices were recorded before and after surgery, and statistical analysis was performed using Graphpad Prism 5 software.… ➡️➡️➡️

Modern Pharmacotherapy of Acute Bacterial Sinusitis: Clinical Trial Results Objective To compare the effectiveness of Cefixim Express and Suprax Solutab in treating acute bacterial sinusitis. Methods 60 adult patients with acute bacterial sinusitis were divided into two groups. Group 1 received Cefixim Express, and Group 2 received Suprax Solutab. Both groups took 400 mg dispersible tablets once daily for 7 days. Patients underwent clinical examinations and symptom assessments before treatment, 3 days after starting therapy, and at the end of the 7-day course. Results Both drugs showed comparable effectiveness in treating acute bacterial sinusitis, with 63.3% of Group 1 and… ➡️➡️➡️

Benefits of Budesonide/Glycopyrronium/Formoterol Fumarate Dihydrate on COPD Overview This post-hoc analysis from the KRONOS study explores the effects of triple therapy with Budesonide/Glycopyrronium/Formoterol Fumarate Dihydrate (BGF) compared to dual therapies on lung function and exacerbations in COPD patients without asthma diagnosis. The focus is on blood eosinophil count and exacerbation history. Practical Solutions For patients with moderate-to-very severe COPD, consideration of a step-up to triple therapy may be beneficial, especially for those with persistent/worsening symptoms and a blood eosinophil count > 100 cells/mm3, even in the absence of recent exacerbations. Value These findings suggest potential benefits of BGF over other… ➡️➡️➡️

COMEDI Study: Improving Cataract Surgery Outcomes Introduction The COMEDI study explores the benefits of combining monofocal and extended depth-of-focus (EDOF) intraocular lenses (IOLs) in cataract surgery. EDOF lenses offer a wider range of vision compared to monofocal lenses, and are a promising alternative to multifocal lenses which can cause visual side effects. Methods and Analysis This study involves 88 bilateral cataract patients and compares the outcomes of combined monofocal and EDOF IOL implantation versus bilateral monofocal IOL implantation. The primary measure is distance corrected intermediate visual acuity, with additional assessments including near visual acuity, reading speed, patient-reported spectacle independence, contrast… ➡️➡️➡️

Efficacy and Safety Evaluation of 177Lu-FAP-2286 in Advanced Lung Cancer Treatment Study Overview The study aimed to assess the effectiveness and safety of peptide-targeted radionuclide therapy (PTRT) with 177Lu-FAP-2286 in patients with advanced lung cancer. Results and Findings Short-term efficacy assessment showed 44% of patients had a partial metabolic response, 33.3% had stable metabolic disease, and 22.22% had progressive metabolic disease. The highest metabolic response after treatment reached 66.89%, with an overall response rate of 77.78%. The median overall survival and progression-free survival (PFS) were 10 months and 6 months, respectively. Patients experienced improvements in overall health status, symptom response,… ➡️➡️➡️

Possibilities of Azilsartan Medoxomil for Preparation for Planned Percutaneous Coronary Intervention in Patients With Type 2 Diabetes Mellitus Key Findings Evaluation of the efficacy and safety of azilsartan medoxomil for preoperative preparation and improving the long-term prognosis of elective percutaneous coronary intervention (PCI) in patients with ischemic heart disease (IHD), arterial hypertension (AH), and type 2 diabetes mellitus (DM). During the study, it was observed that azilsartan medoxomil showed potential benefits in improving renal function and preventing contrast-induced acute kidney injury (CI-AKI) in patients with IHD, AH, and DM. Practical Implications Azilsartan medoxomil demonstrated a significant decrease in glomerular filtration… ➡️➡️➡️

Knee Arthroscopic Surgery in Middle-Aged Patients With Meniscal Symptoms: A 10-Year Follow-up of a Prospective, Randomized Controlled Trial ABSTRACT Background: Previous evaluations of arthroscopic meniscal surgery showed little or no benefit in the short and midterm, but long-term effects were unknown. Purpose: To compare the 10-year outcomes in middle-aged patients with meniscal symptoms between those who received an exercise program alone and those who received knee arthroscopy in addition to the exercise program, focusing on the prevalence of radiographic and symptomatic osteoarthritis (OA), patient-reported outcomes, and clinical status. Study Design: Randomized controlled trial; Level of evidence, 1. Methods: 150 patients… ➡️➡️➡️

Study on Anticoagulant Treatment for Portal Vein Thrombosis in Cirrhosis Patients Objective To compare the safety and effectiveness of two anticoagulant treatments for portal vein thrombosis (PVT) in cirrhosis patients. Methods Cirrhotic patients with PVT received low-molecular-weight heparin calcium (LMWH-Ca) injections for 2 weeks. They were then randomly assigned to receive either warfarin or rivaroxaban for a specified duration. Volumetric changes in PVT were monitored using computed tomography scans. Results Rivaroxaban treatment significantly reduced PVT volume and prevented worsening, while warfarin treatment led to an increase in PVT volume. Rivaroxaban also showed a lower incidence of gastrointestinal bleeding compared to… ➡️➡️➡️

Treatment of Temporomandibular Joint Internal Derangement using MESNA Injection Introduction The study focuses on using MESNA injection to treat temporomandibular joint (TMJ) internal derangement, targeting the inflammation that contributes to TMJ diseases. Objectives The aim was to evaluate the effectiveness of injecting MESNA directly into the TMJ for treating internal derangement. Materials and Methods A randomized clinical trial involved sixty patients with TMJ anterior disc displacement who were unresponsive to conventional treatment. They were divided into two groups, with one receiving MESNA injection and the other receiving a standard treatment. Results Both MESNA and the standard treatment showed significant improvement… ➡️➡️➡️

Tetracycline Three Times Daily Versus Four Times Daily in Bismuth-Containing Quadruple Therapy as the First-Line Treatment of Helicobacter pylori Infection: A Multicenter, Noninferiority, Randomized Controlled Trial ABSTRACT Current guidelines recommend bismuth-containing quadruple therapy for patients newly diagnosed with Helicobacter pylori (H. pylori) infection. This study aimed to compare the efficacy and safety of tetracycline administered three times daily versus four times daily in bismuth-containing quadruple therapy for first-line treatment of H. pylori infection. METHODS This multicenter, noninferiority, randomized controlled study, conducted in China, recruited treatment-naïve adults with H. pylori infection. Patients were randomized 1:1 into two treatment groups to receive… ➡️➡️➡️

Efficacy Comparison of Osteopathic Muscle Energy Techniques and Cervical Mobilization on Pain, Disability, and Proprioception in Cervical Spondylosis Patients Key Findings: Cervical spondylosis (CS) causes persistent neck pain and decreased mobility. This study compared the effectiveness of osteopathic muscle energy technique (MET) and cervical mobilization (CM) on 76 CS patients. Practical Solutions: Both MET and CM reduced pain and disability, but MET combined with electro-thermal therapy (ET) was more effective in improving cervical position sense. Value: These findings provide valuable insights for clinicians treating CS patients and highlight the potential benefits of incorporating MET with ET for improved outcomes. Clinical… ➡️➡️➡️

Relationship between NT-proBNP, Echocardiographic Abnormalities and Functional Status in Patients with Subclinical Diabetic Cardiomyopathy Introduction Diabetes can lead to heart muscle disease (cardiomyopathy) through different mechanisms. The connection between natriuretic peptides, heart structure issues, and functional abilities in diabetic cardiomyopathy (DbCM) patients is not well understood. Methods In this study, 685 patients with asymptomatic DbCM from the ARISE-HF trial underwent tests including echocardiography, lab work, and functional assessments. The participants were grouped by their NT-proBNP levels, and the relationship between NT-proBNP, echocardiographic parameters, and functional measures was analyzed. Results The study found that elevated NT-proBNP levels were not linked to… ➡️➡️➡️

Implementation of Integrated Care for Type 2 Diabetes Mellitus and Periodontitis in Germany: Study Protocol for a Practice-based and Cluster-randomized Trial Background Type 2 Diabetes mellitus (T2DM) and periodontitis have common risk factors and can impact each other. However, primary care and oral health care are currently separate and do not coordinate care for patients with both conditions. This trial aims to assess a new integrated care pathway for patients with T2DM and periodontitis. Methods The trial consists of two practice-based studies: one in dental care settings and the other in primary care settings. It involves dentists and general practitioners… ➡️➡️➡️

Early Anti-Coagulation Therapy in New-Onset Atrial Fibrillation after Coronary Artery Bypass Grafting: A Randomized Trial Pilot Study Background New-onset postoperative atrial fibrillation (POAF) is a common complication after coronary artery bypass grafting (CABG) surgery, increasing the risk of embolism and stroke. This study aimed to compare the feasibility and safety of Warfarin and Rivaroxaban in preventing thrombotic events in POAF patients after isolated CABG. Methods A total of 66 patients were randomized to receive either Rivaroxaban or Warfarin. Major bleeding events within 30 days after discharge were the primary outcome, with secondary outcomes including minor bleeding events and thrombotic episodes.… ➡️➡️➡️

Patient-Representing Population’s Perceptions of GPT-Generated Versus Standard Emergency Department Discharge Instructions: Randomized Blind Survey Assessment ABSTRACT Discharge instructions from the emergency department (ED) to home are crucial for patient communication but often get overlooked. Generative artificial intelligence and large language models (LLMs) offer a solution to create high-quality and personalized discharge instructions. This study aimed to assess patient perspectives of LLM-generated discharge instructions using ChatGPT in the ED. METHODS The study involved creating realistic ED encounters and generating LLM-generated discharge instructions using GPT-4 in Azure OpenAI Service. Standard discharge instructions were also created for comparison. These instructions were then presented… ➡️➡️➡️

Role of Bacillus coagulans (Heyndrickxia coagulans)BCP92 in managing irritable bowel syndrome: A randomized, double-blind, multicenter, placebo-controlled clinical trial ABSTRACT Irritable bowel syndrome (IBS) is a significant global healthcare burden, and effective intervention is crucial. This study investigated the effectiveness and safety of Bacillus coagulans BCP92, a probiotic, in managing IBS symptoms. METHODS A randomized controlled trial with 100 participants assessed various parameters such as IBS severity, digestive and gastrointestinal symptom frequency, stool consistency, interleukin-6 levels, stress relief, and anxiety levels over 12 weeks. RESULTS B. coagulans BCP92 significantly improved IBS severity, gastrointestinal symptom frequency, and stool consistency compared to the… ➡️➡️➡️

Tildrakizumab Real-World Effectiveness and Safety Over 64 Weeks in Patients With Moderate-to-Severe Plaque Psoriasis Background Tildrakizumab, a treatment for moderate-to-severe plaque psoriasis, was evaluated for its real-world effectiveness and safety over 64 weeks. Methods Adults with moderate-to-severe plaque psoriasis received tildrakizumab 100 mg at specified intervals. Effectiveness was measured using body surface area affected, Physician Global Assessment, and Psoriasis Area and Severity Index. Adverse events were also monitored. Results Out of 55 patients, 45 completed the study and 36 received all doses of tildrakizumab. The treatment led to significant improvements in BSA, sPGA, and PASI scores. The majority of patients… ➡️➡️➡️

Exploring the Impact of Home-Based Exercise Adherence on Low Back Pain Recovery Key Findings Adherence to home-based exercise (HBE) recommendations is crucial in physiotherapy for low back pain (LBP) patients. This study investigated the relationship between adherence to HBE and changes in physical function, pain intensity, and recovery from LBP. Practical Solutions Adherence to HBE was assessed using the Exercise Adherence Scale (EXAS) at each treatment session. The study identified three adherence trajectories: declining adherence, stable adherence, and increasing adherence. However, no significant associations were found between adherence and changes in physical functioning or pain. Value These findings suggest that… ➡️➡️➡️

Radiofrequency Ablation for Bile Duct Cancer (ACTICCA-2 Trial) Key Findings and Practical Solutions The ACTICCA-2 trial assessed the impact of adding radiofrequency ablation (RFA) to biliary stenting in patients with unresectable bile duct cancer undergoing palliative systemic therapy. Patients were randomized to receive either RFA plus bile duct stenting or bile duct stenting alone, with both groups receiving palliative systemic treatment. The primary endpoint was the time to first biliary event, with secondary endpoints including overall survival, safety, quality of life, clinical event rate, and hospital stays. The study aims to evaluate the efficacy and safety of adding RFA to… ➡️➡️➡️

Impact of a Community Pharmacy-Based Medication Therapy Management Program on Clinical and Humanistic Outcomes in Patients with Uncontrolled Diabetes: A Randomised Controlled Trial Abstract This study aimed to assess the impact of a community pharmacy (CP)-based medication therapy management (MTM) program on the health and satisfaction of patients with uncontrolled diabetes. Patients were randomly assigned to either the MTM program provided by pharmacists or standard care. The primary outcome was the change in HbA1c over 6 months. Secondary outcomes included changes in clinical parameters, types of drug-related problems, health service utilization, adherence, diabetes distress, and patient satisfaction with the service… ➡️➡️➡️