Clinical Trials

Background Mirvetuximab soravtansine (MIRV) is a new treatment for women with platinum-resistant ovarian cancer. It targets a specific protein (folate receptor α) on cancer cells. This treatment has been approved by the FDA in the USA. Study Overview The MIRASOL trial compared MIRV with standard chemotherapy. It aimed to see which treatment helped patients live […] ➡️➡️➡️

“`html Study Overview The TALAPRO-2 trial explored the effectiveness of a combination treatment using talazoparib and enzalutamide for men with a specific type of advanced prostate cancer. This trial showed promising results in helping patients live longer without their cancer worsening compared to a placebo treatment. Trial Details This phase 3 trial involved 399 patients […] ➡️➡️➡️

Background Patients with advanced prostate cancer that does not respond to hormone therapy often have a poor outlook. New treatment options are needed. The TALAPRO-2 study found that combining talazoparib with enzalutamide improved survival without disease progression compared to a placebo with enzalutamide. Study Overview TALAPRO-2 was a large clinical trial involving 805 men across […] ➡️➡️➡️

Clinical Importance Aspirin and intravenous immunoglobulin (IVIG) are commonly used to treat Kawasaki disease (KD) to help prevent heart issues. However, hospitals don’t always agree on the right dose and duration of aspirin treatment. More large studies are needed to understand how effective high-dose aspirin really is. Study Goals This study aimed to compare the […] ➡️➡️➡️

Study Overview This study looked at bromhexine, a common over-the-counter medicine, to see if it could help treat COVID-19 in patients with mild to moderate symptoms. Aim of the Study The goal was to find out if taking oral bromhexine could reduce the viral load and improve symptoms in patients with active SARS-CoV-2 infection. How […] ➡️➡️➡️

Study Overview This study focused on multiple sclerosis (MS), a chronic condition that creates caregiving challenges. It aimed to evaluate how a patient-centered empowerment program using telenursing could help individuals with MS manage their health better. Study Details The research was a double-blinded, randomized clinical trial with 90 participants diagnosed with MS for at least […] ➡️➡️➡️

Background Chronic lymphocytic leukaemia (CLL) is the most common type of leukaemia and weakens the immune system. New treatments, called Bruton tyrosine kinase inhibitors (BTKi), have greatly improved how we manage CLL. However, these treatments can reduce the body’s response to vaccines, including those for COVID-19. Study Purpose This study aimed to find out if […] ➡️➡️➡️

Background Panic disorder is a serious anxiety condition where people experience intense fear of panic attacks without any clear reason. Agoraphobia, a related condition, involves fear of situations where escape might be hard. Both disorders can significantly affect a person’s life. A potential treatment is internet-based cognitive behavioral therapy (iCBT), which can be accessed by […] ➡️➡️➡️

Background Symptom checker apps (SCAs) help patients decide if they need medical care and what kind of care to seek. Previous studies focused mainly on how accurate and user-friendly these apps are. However, there has been little research on how these apps affect the quality of care, especially the interaction between patients and doctors. Objective […] ➡️➡️➡️

Importance of Preventing Kidney Injuries Over 10% of patients in the US who undergo certain procedures face serious kidney injuries, leading to higher healthcare costs and health issues. Effective prevention methods exist, but they are not always followed, and we need to understand which methods are cost-effective. Study Objective The goal of this study was […] ➡️➡️➡️

Introduction Sleep bruxism is when you clench or grind your teeth while sleeping. This can lead to tooth wear and jaw problems. The most common treatment is wearing an occlusal splint to help protect your teeth. Study Purpose This study looked at how much wear and pain different types of occlusal splints cause in people […] ➡️➡️➡️

Study Overview This study explored how Ajwa dates can help improve the quality of life (QoL) and reduce inflammation in patients with schizophrenia who are taking risperidone, a common medication for this condition. Who Participated? The study involved 44 hospitalized patients aged 20 to 45 years, all diagnosed with schizophrenia. They were treated with risperidone […] ➡️➡️➡️

Overview of Chronic Limb-Threatening Ischemia (CLTI) Chronic limb-threatening ischemia (CLTI) is a serious health issue affecting patients with poor blood flow in their legs. It can lead to significant pain and mobility challenges. What is Low-Intensity Pulsed Ultrasound (LIPUS)? Low-intensity pulsed ultrasound (LIPUS) is a non-invasive treatment that has been found to help improve conditions […] ➡️➡️➡️

Background As more people are diagnosed with cancer, helping them manage their recovery is essential. Technology, especially apps that track physical activity, plays a vital role in supporting patients. Staying active can improve health and quality of life for cancer patients, but we still need more evidence on how effective these digital tools are over […] ➡️➡️➡️

Understanding Internet Gaming Disorder (IGD) Internet Gaming Disorder (IGD) is a condition where individuals have uncontrolled gaming habits. This can lead to emotional problems, neglect of responsibilities, and harm to personal relationships. IGD is linked to challenges in brain function, particularly in areas responsible for decision-making and emotional control. Purpose of the Study This study […] ➡️➡️➡️

Understanding Primary Axillary Hyperhidrosis Primary axillary hyperhidrosis (PAH) is a condition where individuals experience excessive sweating in their underarms. This can be challenging and affect daily life. Treatment Options The FDA has approved onabotulinum toxin A (OnaBTX-A), commonly known as Botox®, for treating severe PAH. Recent studies suggest that letibotulinum toxin A (LetiBTX-A) may also […] ➡️➡️➡️

Introduction Atrophic acne scarring is a common issue that many people face. Various treatments exist, but combining them often leads to better results. This study compares two treatments: topical insulin and platelet-rich plasma (PRP) used alongside fractional CO2 laser therapy. Study Overview The study involved 30 patients with atrophic acne scars. Each patient received four […] ➡️➡️➡️

Understanding the Study on Post-Acne Erythema Post-acne erythema (PAE) is a common issue after acne treatment, causing emotional distress and social challenges for many individuals. This study explores the effectiveness of combining Intense Pulsed Light (IPL) therapy with intradermal tranexamic acid (TXA) injections to reduce PAE. Study Overview In this trial, 33 patients aged 16 […] ➡️➡️➡️

Purpose This study examines how women with metastatic breast cancer (MBC) use digital mental health interventions (DMHI) to improve their access to support. It focuses on a specific program called Finding My Way-Advanced (FMW-A), which offers personalized resources for these women. Methods Twenty women with MBC participated in interviews after using either the FMW-A program […] ➡️➡️➡️

Background Dual antiplatelet therapy is commonly used for patients with acute coronary syndrome (ACS). However, there is uncertainty about the best treatment option in North America. This study compares the effectiveness and safety of two medications: acetylsalicylic acid (ASA) combined with ticagrelor versus ASA with clopidogrel in ACS patients. Study Overview This was a practical, […] ➡️➡️➡️