Clinical Trials

Background Access to pre-exposure prophylaxis (PrEP) is crucial for reducing HIV cases in the U.S. However, certain groups, such as young people and minorities in North Carolina, are not using PrEP as much as they should. In 2018, the South had over half of new HIV diagnoses but only a third of PrEP users. This […] ➡️➡️➡️

Introduction DREAMS-START is a program designed to help people with dementia who have trouble sleeping. This study looked at how well the program worked and what factors influenced its success. Methods We used a mix of methods to gather information. We checked how well participants followed the program and interviewed family members and facilitators involved […] ➡️➡️➡️

Background High blood pressure (BP) is a widespread issue, affecting about one-third of people globally. Poor sleep quality can increase the risk of high BP, but this is something we can improve. Yoga may help lower BP, but we need more information about how long and how intense the sessions should be. This study aims […] ➡️➡️➡️

Clinical Comparison of Lithium and Quetiapine for Depression This study examined whether quetiapine is better than lithium for patients with treatment-resistant depression over a year. Treatment-resistant depression is when standard antidepressants don’t help enough. Study Overview The trial involved 212 adults from six NHS trusts in England, who were experiencing major depressive disorder. They had […] ➡️➡️➡️

“`html Background Adipose extracellular matrix/stromal vascular fraction gel (ECM/SVF-gel) is a treatment that includes stem cells and other components from fat tissue. It helps produce collagen and can fill in scars. Aim This study aimed to compare the effectiveness and safety of ECM/SVF-gel injections for treating acne scars with CO2 fractional laser (CO2FL) treatments. Methods […] ➡️➡️➡️

Introduction Recent studies have compared aggressive treatments for prostate cancer (PCa) with monitoring approaches. While aggressive treatments show slight survival benefits, they can significantly lower quality of life. A new method called MR fusion cryoablation (MRFC) is showing promise. This study looks at men diagnosed with prostate cancer through a specific biopsy method and treated […] ➡️➡️➡️

Background Traditional treatments for Raynaud’s phenomenon (RP) often don’t work well because they don’t address all the causes of the condition. This study looks at a new treatment that combines high-density fat grafting (HDFG) with botulinum toxin A (BTX-A) to see if it can help patients better. Study Overview Eleven patients with 20 affected hands […] ➡️➡️➡️

Background Stroke is a major cause of disability and death around the world, especially in poorer countries. Many people with high blood pressure and diabetes do not manage their conditions well. In Nigeria, less than 50% of patients take their medications as prescribed. This study looks at whether sending text message reminders can help patients […] ➡️➡️➡️

“`html Introduction The elderly are at higher risk of severe illness and death from COVID-19. About 20% of older adults may not have antibodies three to five months after their second COVID-19 vaccine dose. This study investigates whether probiotics can help boost antibody levels after vaccination. Study Overview This study is a randomized controlled trial […] ➡️➡️➡️

Study Overview This study aimed to assess how effective and safe a treatment called sonolysis is when used during a surgical procedure known as carotid endarterectomy. The research was conducted across 16 centers in Europe and involved 1,004 patients, with an average age of 68 years. What is Sonolysis? Sonolysis uses low-intensity ultrasound waves to […] ➡️➡️➡️

Background Adolescents in Sub-Saharan Africa face a serious challenge with HIV, and many also struggle with depression. This can make it hard for them to stay engaged in their HIV care. We are testing two versions of the Friendship Bench program in Malawi to see if they can help reduce depression and improve care for […] ➡️➡️➡️

Background The European guidelines recommend using digital mammography (DM) or digital breast tomosynthesis (DBT) for screening women who are at average risk for breast cancer. A study called IMPETO in Tuscany, Italy, is looking into how effective DBT is for screening. There is not much information about how women feel about this new technology, so […] ➡️➡️➡️

Understanding the Impact of Apalutamide in Prostate Cancer Treatment Background Research has shown that the effectiveness of apalutamide, a drug for treating metastatic castration-sensitive prostate cancer (mCSPC), may vary based on the number of bone metastases a patient has. Study Overview This study analyzed data from 1,052 patients who participated in the TITAN trial, comparing […] ➡️➡️➡️

Clinical Trial Summary Study Overview This clinical trial looked at how selective caries removal in deep cavities affects tooth sensitivity, pulp health, and new dentin formation. The study also examined the effects of using a specific type of light therapy called photobiomodulation (PBM). Methods Twenty-seven permanent molars with deep cavities were divided into three groups: […] ➡️➡️➡️

Understanding the Link Between Dietary Fatty Acids and Ovarian Cancer Purpose: There is ongoing debate about how dietary fatty acids (FAs) may affect the risk of ovarian cancer (OC). This study aimed to clarify this relationship using data from a large group of women. Study Overview Methods: The research included women from the Prostate, Lung, […] ➡️➡️➡️

Background Disseminated histoplasmosis is a serious infection that can be life-threatening, especially for people with advanced HIV. Diagnosing this condition can be challenging due to unclear symptoms and limitations in traditional testing methods. Study Objectives This study looked at chest CT scans of patients with disseminated histoplasmosis and advanced HIV to identify common patterns that […] ➡️➡️➡️

Understanding the Crisis Opioids are a leading cause of overdose deaths in the USA, creating a significant public health issue. Many patients also struggle with mental health disorders, which complicate treatment efforts and lead to worse outcomes. Collaborative Care Approach Collaborative care has been shown to improve treatment for individuals dealing with both substance use […] ➡️➡️➡️

Understanding Bone Health in Parkinson’s Disease Parkinson’s disease (PD) increases the chances of falling and developing osteoporosis, which raises the risk of fractures. Recent guidelines suggest that those with PD should undergo a risk assessment, like the FRAX tool, but current treatment pathways are not very effective. To improve this, we created a specific algorithm […] ➡️➡️➡️

Overview of the Study Smoking significantly increases the risk of developing chronic obstructive pulmonary disease (COPD), contributing to 80% of cases. One of the early signs of COPD is reduced physical ability, which is linked not only to lung function but also to issues with the musculoskeletal system. Study Goals The study aimed to compare […] ➡️➡️➡️

Effects of Acupuncture on Bell’s Palsy This study looked at how acupuncture can help patients with Bell’s facial paralysis during the early stages of their condition. We tested this using a method called surface electromyography to measure muscle strength and fatigue in the face. Study Overview Sixty patients with acute Bell’s palsy were divided into […] ➡️➡️➡️