Phase II Study on Langerhans Cell Histiocytosis in Japan Key Points: – The study aims to improve outcomes for patients with Langerhans cell histiocytosis (LCH) by addressing recurrence and complications such as central diabetes insipidus and neurodegenerative diseases. – Dexamethasone is being tested to suppress LCH-associated inflammation, particularly in the central nervous system, while intrathecal…
Comparing the Effectiveness of Text-Message Reminders and Patient Navigation for Bowel Cancer Screening Introduction Participation in bowel cancer screening is lower in diverse and deprived regions. Text message reminders and patient navigation can help increase participation. This study aims to compare their effectiveness and cost-effectiveness. Methods and Analysis A three-arm randomised controlled trial will compare…
Comparison of the Effect of Two Recruitment Manoeuvres to Conventional Ventilation on Lung Atelectasis in Paediatric Laparoscopic Surgery: A Prospective Randomised Controlled Trial Background Paediatric laparoscopic surgeries often result in pulmonary atelectasis. This study aimed to compare the use of recruitment manoeuvres or continuous positive airway pressure (CPAP) to conventional ventilation in preventing atelectasis. Objective…
Association of Demographics, Lumbar Range of Motion, and Disability in Chronic Low Back: Baseline Data Analysis BMC Musculoskelet Disord. 2024 Jun 22;25(1):489. doi: 10.1186/s12891-024-07613-9. Background: Low back pain (LBP) poses a substantial burden on low and middle-income countries like Pakistan. This study aimed to explore the relationship between demographic factors, lumbar range of motion, and…
Comparison of Endoscopic versus Focused Parathyroidectomy in Surgical Management of Single-Gland Primary Hyperparathyroidism: A Randomized Clinical Trial Key Findings: The success rate for endoscopic parathyroidectomy was 95.3% compared to 77.1% for focused parathyroidectomy within the first five minutes. Postoperative calcium levels were significantly lower in the focused parathyroidectomy group. The focused parathyroidectomy method had a…
DISCOVER Trial: Automated Feedback for Internet-Based Depression Screening Background Many people with depression go undiagnosed and untreated despite effective treatments being available. We wanted to see if providing automated feedback after internet-based depression screening could help reach and provide evidence-based care for these individuals. Methods The DISCOVER trial was conducted in Germany and involved individuals…
Pilot Clinical Trial on Oral Hygiene Products Summary: A pilot study was conducted to evaluate oral hygiene products containing a prebiotic and paraprobiotic based on Lactobacillus plantarum. It aimed to assess patient satisfaction, recruitment rate, and rebalancing of the oral microbiota for future research. Findings: – All products were well-tolerated with no adverse events reported.…
Effect of Topical Brinzolamide on Visual Function in Infantile Nystagmus Syndrome Key Findings A randomized control trial evaluated the impact of topical brinzolamide on visual function and eye waveforms in infantile nystagmus syndrome (INS). Highlights: Significant improvement in INS waveform characteristics and visual acuity with brinzolamide No significant change in head position and stereopsis No…
EARLY Randomized Clinical Trial: 5:2 Intermittent Fasting Meal Replacement Diet and Glycemic Control for Adults With Diabetes Key Findings: An intermittent fasting plan of 2 nonconsecutive fasting days and 5 days of habitual intake per week combined with a meal replacement diet (5:2 MR) showed significant benefits for patients with early type 2 diabetes. Study…
Effect of Acupuncture on Tic Disorder: A Randomized Controlled Clinical Trial BMC Complement Med Ther. 2024 Jun 20;24(1):240. doi: 10.1186/s12906-024-04534-x. Background: Acupuncture is used to treat tic disorder, but there is a lack of clinical evidence supporting its efficacy. This study aims to investigate the potential mechanism of acupuncture in treating tic disorder by examining…
Adoption of Cardiopulmonary Exercise Testing in Rehabilitation of Coronary Artery Disease Patients BMC Cardiovasc Disord. 2024 Jun 21;24(1):313 Summary: This study explored the use of cardiopulmonary exercise testing in patients with coronary artery disease (CAD) and its impact on exercise ability and cardiopulmonary function. Significant improvements in health outcomes and quality of life were observed.…
Precision Medicine to Redefine Insulin Secretion and Monogenic Diabetes-Randomized Controlled Trial (PRISM-RCT) Highlights of the Study We designed a patient-centered care model to evaluate its impact on clinical outcomes in young-onset type 2 diabetes patients. Research Design and Methods The trial evaluates a multicomponent care model using technology, biogenetic markers, and patient-reported outcomes in patients…
miR-221-3p: A Potential Biomarker for Chronic Periodontitis Overview Researchers investigated the role of miR-221-3p in chronic periodontitis (CP) development and management. They aimed to uncover its diagnostic potential and therapeutic implications. Key Findings miR-221-3p levels were lower in CP patients compared to healthy individuals. miR-221-3p demonstrated high diagnostic accuracy for CP, showing potential as a…
The Effect of Tub Bathing on Newborns Undergoing Phototherapy: A Clinical Trial Objective To study the impact of tub bathing on the skin and bilirubin levels of newborns undergoing tunnel and light-emitting diode phototherapy. Methods Newborns with hyperbilirubinemia receiving tunnel or light-emitting diode phototherapy were randomly assigned to either a bath or no bath group.…
Randomised, Split-Face Study of Dermocosmetic Cream for Rosacea Published in Skin Research and Technology, June 2024 Objective: To assess the benefit of a dermocosmetic cream (DC cream) containing Sphingobioma xenophaga extract and soothing agent in adult females with rosacea-associated erythema and sensitive skin. Methods: The study involved a 28-day phase where DC was applied twice…
The effect of educational intervention based on health belief model on colorectal cancer screening behaviors BMC Public Health. 2024 Jun 19;24(1):1640. doi: 10.1186/s12889-024-19180-8. Summary: This study aimed to assess the impact of an educational intervention based on the health belief model (HBM) on colorectal cancer screening behaviors in individuals aged 50 and above. Methods: 134…
Web-Based, Human-Guided, or Computer-Guided Transdiagnostic Cognitive Behavioral Therapy in University Students With Anxiety and Depression: Randomized Controlled Trial Key Findings: Web-based interventions were marginally more effective than usual care over 6 months. All groups showed significant improvement in depression and anxiety symptoms over time. Participants in the human-guided condition attended more sessions than those in…
A Randomized, Double-Blind, Placebo-Controlled Clinical Trial on the Effect of a Dietary Supplement Containing Dry Artichoke and Bergamot Extracts on Metabolic and Vascular Risk Factors in Individuals with Suboptimal Cholesterol Levels Key Findings The study found that a dietary supplement containing dry extracts of bergamot and artichoke significantly improved serum lipid concentration and insulin sensitivity,…
Efficacy and Mechanisms of TCPS Qigong for Insomnia in College Students Protocol for a Double-Blind, Randomized Controlled Trial Background: Insomnia in college students is often overlooked despite its impact on health and wellbeing. Improving sleep quality through targeted interventions can reduce the risk of related health issues. Qigong exercises, specifically Three-circle Post Standing (TCPS), have…
Efficacy and Safety of Eliapixant in Endometriosis-Associated Pelvic Pain: The SCHUMANN Study Published in BMC Women’s Health, June 19, 2024 Background: The SCHUMANN study assessed the effectiveness and safety of eliapixant in treating endometriosis-associated pelvic pain (EAPP). Methods: This was a phase 2b study involving women with surgically diagnosed endometriosis and EAPP. Participants were randomly…