Double-blind
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePentoxifylline ameliorates subclinical atherosclerosis progression in patients with type 2 diabetes and chronic kidney disease: a randomized pilot trial
Pentoxifylline Reduces Subclinical Atherosclerosis in Patients with Type 2 Diabetes and Chronic Kidney Disease Key Findings: Pentoxifylline (PTF) shows positive effects on the progression of subclinical atherosclerosis (SA) in patients with type 2 diabetes mellitus and chronic kidney disease (CKD). Practical Solutions: PTF treatment resulted in improved carotid intima-media thickness (CIMT), increased levels of the […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe effects of remimazolam in combination with estazolam on postoperative hemodynamics and pain intensity in patients undergoing laparoscopic gastrointestinal surgery
Study Title The effects of combining remimazolam with estazolam on postoperative hemodynamics and pain intensity in patients undergoing laparoscopic gastrointestinal surgery Published in BMC Surgery, August 24, 2024 PMID: 39182049 | DOI: 10.1186/s12893-024-02527-8 Objective This study aimed to investigate the effects of combining remimazolam with estazolam on hemodynamics and pain levels after laparoscopic gastrointestinal surgery. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Community-engaged randomised controlled trial to disseminate COVID-19 vaccine-related information and increase uptake among Black individuals in two US cities with rheumatic conditions
Community-Engaged Trial to Increase COVID-19 Vaccine Uptake in Black Individuals with Rheumatic Conditions Published in BMJ Open, August 24, 2024 Background: In the US, there are disparities in COVID-19 infection and vaccine uptake among historically marginalized racial and ethnic groups. People with rheumatic conditions, especially those who are immunocompromised, are at higher risk for severe […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSystemic and cerebro-cardiac biomarkers following traumatic brain injury: an interim analysis of randomized controlled clinical trial of early administration of beta blockers
Interim Analysis of Beta-blocker Use in Traumatic Brain Injury Key Highlights This interim analysis explores the impact of early administration of beta-blockers on adrenergic surge, pro-inflammatory cytokines, and traumatic brain injury (TBI) biomarkers. Patients with positive high-sensitivity troponin T (HsTnT) levels received propranolol, while those with negative test were randomized to receive propranolol or placebo. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseKinetic Profiling of RAS Mutations With Circulating Tumor DNA in the Canadian Cancer Trials Group CO.26 Trial Suggests the Loss of RAS Mutations in Neo-RAS-Wildtype Metastatic Colorectal Cancer Is Transient
Kinetic Profiling of RAS Mutations in Metastatic Colorectal Cancer Study Overview Researchers tracked RAS mutation status in metastatic colorectal cancer patients over time using circulating tumor DNA (ctDNA) sequencing during the CO.26 trial, which assessed durvalumab + tremelimumab treatment in heavily pretreated patients. Key Findings Among the patients with RAS mutations, a small percentage (3.2%-6.3%) […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseShared Decision-Making in Colorectal Cancer Screening for Older Adults: A Secondary Analysis of a Cluster Randomized Clinical Trial
Shared Decision-Making in Colorectal Cancer Screening for Older Adults: A Secondary Analysis of a Cluster Randomized Clinical Trial Summary Deciding whether to stop colorectal cancer (CRC) screening tests in older adults can be challenging. This study evaluated the impact of physician training in shared decision-making (SDM) and electronic previsit reminders on the receipt of patient-preferred […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCharacterizing HIV drug resistance in cases of vertical transmission in the VESTED randomized antiretroviral treatment trial
Characterizing HIV Drug Resistance in Vertical Transmission Cases Study Overview The VESTED trial compared the safety and effectiveness of three different antiretroviral treatment regimens in pregnant and postpartum women with HIV. The study aimed to evaluate the occurrence of vertical HIV transmission (VT) in infants born to these women and to assess HIV drug resistance […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
A Randomized Controlled Trial of Two Parent-Child Parallel Interventions to Enhance Positive Adaptation of Immigrant Families in Hong Kong: The Moderating Role of Depressive Symptoms
Enhancing Positive Adaptation of Immigrant Families in Hong Kong: Clinical Trial Results Overview Our research team conducted a randomized controlled trial to enhance positive adaptation among immigrant parents and children in Hong Kong. We developed two parallel interventions aiming to address psychological and sociocultural adaptation difficulties faced by immigrant families. Interventions Two interventions were conducted: […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseStreamlined Genetic Education and Cascade Testing in Men from Hereditary Breast Ovarian Cancer Families: A Randomized Trial
Streamlined Genetic Education and Cascade Testing in Hereditary Cancer Families: Key Findings Introduction When a pathogenic BRCA1 or BRCA2 mutation is found in a family, it is important for family members to undergo cascade genetic testing to guide screening and treatment decisions. However, men are less likely than women to pursue cascade testing. To address […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA gut microbiota rheostat forecasts responsiveness to PD-L1 and VEGF blockade in mesothelioma
Study Title: A gut microbiota rheostat forecasts responsiveness to PD-L1 and VEGF blockade in mesothelioma Nature Communications, August 21, 2024 Key Findings: Malignant mesothelioma, a rare cancer linked to asbestos exposure, has limited treatment options and poor prognosis. A multi-center phase II clinical trial (MiST4, NCT03654833) evaluated atezolizumab and bevacizumab (AtzBev) in relapsed mesothelioma patients, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseHSD3B1 genotype and outcomes in metastatic hormone-sensitive prostate cancer with androgen deprivation therapy and enzalutamide: ARCHES
HSD3B1 Genotype and Outcomes in Metastatic Prostate Cancer Practical Solutions and Value Highlights HSD3B1 genotype plays a role in metastatic hormone-sensitive prostate cancer (mHSPC) outcomes. The AP allele is linked to castration resistance, particularly in low-volume tumors, affecting post-progression mortality and treatment-emergent adverse events. Enzalutamide plus androgen deprivation therapy (ADT) in men with mHSPC showed […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Effect of narrative photography to improve physical therapy students’ learning outcomes when studying heart transplantation: A randomized controlled trial
Effect of Narrative Photography on Physical Therapy Students’ Learning Outcomes in Heart Transplantation Nursing and Health Sciences, September 2024, Volume 26, Issue 3, Article e13155 Physical therapy students need to understand how to care for patients undergoing heart transplantation, including their emotional and practical needs. This study compared the effectiveness of a narrative photography (NP) […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseComparison of Two Symptom Checkers (Ada and Symptoma) in the Emergency Department: Randomized, Crossover, Head-to-Head, Double-Blinded Study
Comparison of Two Symptom Checkers (Ada and Symptoma) in the Emergency Department: Randomized, Crossover, Head-to-Head, Double-Blinded Study ABSTRACT Emergency departments (EDs) are often overcrowded, and nonurgent patients frequently seek care there. Symptom checkers (SCs) provide immediate access to disease suggestions and recommended actions, potentially improving patient flow. However, there is a lack of evidence supporting […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEvaluating the Efficacy of a Digital Therapeutic (CT-152) as an Adjunct to Antidepressant Treatment in Adults With Major Depressive Disorder: Protocol for the MIRAI Remote Study
Evaluating the Efficacy of a Digital Therapeutic (CT-152) as an Adjunct to Antidepressant Treatment in Adults With Major Depressive Disorder: Protocol for the MIRAI Remote Study ABSTRACT Major depressive disorder (MDD) is a common and highly disabling condition. Many individuals with MDD do not experience full symptom relief with current treatments, so new options are […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSpeech-related parameters are sensitive measures of acetylcholinesterase inhibitor therapy in mild Alzheimer’s disease
Study Highlights Speech-related temporal parameters (SRTPs) may be sensitive indicators of the efficacy of acetylcholinesterase (AChE) inhibitor therapy in mild Alzheimer’s disease. Automatic speech recognition in the Speech-Gap Test® revealed improvements in filled pause duration ratio, count ratio, and frequency after 12 and 24 weeks of donepezil treatment. ADAS-Cog total scores showed slight improvement, with […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Efficacy of a Mobile App-Based Intervention for Young Adults With Anxiety Disorders: A Randomized Clinical Trial
Efficacy of a Mobile App-Based Intervention for Young Adults With Anxiety Disorders: A Randomized Clinical Trial ABSTRACT Young adults often face undertreatment for anxiety disorders. Maya, a mobile cognitive behavioral therapy (CBT) intervention, was tested in a randomized clinical trial. The study aimed to assess the efficacy and engagement with the intervention, comparing the effects […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy and feasibility analysis of compound fluocinolone acetonide cream combined with guaiazulene in the treatment of neurodermatitis
Efficacy and Feasibility of Combined Treatment for Neurodermatitis Objective To assess the effectiveness and practicality of using compound fluocinolone acetonide cream and guaiazulene in treating neurodermatitis. Methods A study was conducted on 92 neurodermatitis patients, dividing them into control and experimental groups. The control group received compound fluocinolone acetonide cream, while the experimental group also […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseMultivitamin Compliance Reduces Injuries of Female Recruits at Air Force Basic Training: A Randomized Controlled Cohort Study
Multivitamin Compliance Reduces Injuries of Female Recruits at Air Force Basic Training: A Randomized Controlled Cohort Study ABSTRACT Introduction: Basic military training (BMT) for U.S. Air Force and Space Force recruits is critical, but musculoskeletal injuries (MSKI) can threaten success. Trainees with nutritional deficiencies are at higher risk, so efforts to mitigate issues include providing […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffect of early administration of tetracosactide on mortality and host response in critically ill patients requiring rescue surgery: a sensitivity analysis of the STOPSHOCK phase 3 randomized controlled trial
Effect of Early Administration of Tetracosactide on Mortality and Host Response in Critically Ill Patients Requiring Rescue Surgery Summary Early administration of tetracosactide (TCS10) in critically ill patients undergoing rescue surgery significantly reduced 30-day mortality and improved hemostatic disorders. The drug targeted melanocortin receptors (MCRs) and showed promising results in a phase 3 randomized controlled […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseUsing ultrasound radiomics to forecast adverse cardiovascular events in patients with acute coronary syndrome after percutaneous coronary intervention
Ultrasound Radiomics for Forecasting Adverse Cardiovascular Events Objective Assessing the effectiveness of ultrasound-based radiomics in predicting major adverse cardiovascular events (MACE) within 1 year after percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) patients. Methods 161 ACS patients who underwent PCI were included, with 114 in the training set and 47 in the validation […] ➡️➡️➡️