Clinical Outcomes of Selective Dentin Removal for Deep Caries Study Overview This study compared two methods for treating deep caries in permanent teeth: selective removal to soft dentin (SRSD) with or without calcium silicate (CS) and selective removal to firm dentin (SRFD). Study Details Conducted from November 2018 to March 2020, the study involved 165…
Effectiveness of a Multimodal Therapy for Allergic Rhinitis Study Overview This study investigates how well a multimodal therapy works for treating allergic rhinitis. Study Design We conducted a randomized controlled trial with 100 patients. They were divided into two groups: one received multimodal therapy while the other received standard treatment. Each group had 50 patients…
Effect of Transcutaneous Electro-Stimulation on Postoperative Pain in Thoracic Surgery Background Chest pain after thoracic surgery is a challenging issue. Proper pain management is essential to prevent complications like ineffective coughing and shallow breathing. Methods This study aimed to evaluate the effectiveness of transcutaneous electrical stimulation (TENS) in managing postoperative pain after thoracotomy. A total…
Efficacy of 4% Tetracaine Gel vs. Lidocaine-Prilocaine Cream for Eyelid Surgery Pain Relief Background Local anesthetic injections can be very painful, which may discourage patients from accepting necessary procedures. Objective This study aimed to compare the effectiveness and side effects of 4% tetracaine gel (TG) and lidocaine-prilocaine cream (LPC) in reducing pain during local anesthetic…
Predictors for Pain and Function in Plantar Fasciopathy Background Plantar fasciopathy is a common condition that causes heel pain and affects daily activities and quality of life. While many people recover, some continue to experience pain. This study looks at what factors can predict pain and function one year after starting treatment. Methods This study…
Effect of Cooled Haemodialysis on Cognition in Patients with End-Stage Kidney Disease (ECHECKED) Study Overview This study looked at whether cooler haemodialysis can help improve brain function in patients with severe kidney disease. Cognitive issues are common in these patients, and we wanted to explore this potential solution. Study Design We randomly assigned 90 patients…
Cardiac Safety in COVID-19 Treatment: HAZDPac Study Objective The study aimed to evaluate the safety of a combination therapy called HAZDPac for treating COVID-19 patients. This therapy includes Hydroxychloroquine, Azithromycin, Vitamin C, Vitamin D, and Zinc. We focused on concerns regarding heart rhythm issues and QTc interval prolongation. Study Design This was a Phase II…
Prehabilitation Exercise Training for Patients with Multiple Myeloma Background Patients with multiple myeloma often face significant loss of muscle strength, which can lead to worse survival rates. At the time of autologous stem cell transplant (ASCT), over half of these patients have low muscle mass. This can cause longer hospital stays and various health issues,…
Study Overview Objective: This study investigates the effectiveness of photodynamic therapy (aPDT) as an additional treatment for patients with apical periodontitis and fistulas. A fistula is an abnormal channel that forms from the infected area at the tooth’s root to the gum surface, complicating treatment. The goal is to see if aPDT can improve the…
Late Gadolinium Enhancement of Nonischemic Cardiomyopathy Study Study Overview This study compares the effectiveness of 5.0-T and 3.0-T cardiac MRI in visualizing late gadolinium enhancement (LGE) in patients with nonischemic cardiomyopathy. Key Findings No difference in acquisition time: The time taken to obtain images at 5.0 T was similar to that at 3.0 T. Better…
Comparison of Extubation Techniques in ICU Patients Objective The goal of this study was to compare three different extubation techniques for patients on mechanical ventilation in the ICU. Methods This was a prospective randomized controlled study involving patients from the First Affiliated Hospital of Guangxi Medical University between July and November 2023. Patients were randomly…
Cost-Effectiveness of AI in Ultrasound Image Quality Control Study Overview This study compared the cost-effectiveness of AI-based methods versus manual methods for ultrasound image quality control (QC) in perinatal screening. Methods Ultrasonographers and pregnant volunteers were recruited from Hunan Maternal and Child Health Hospital in May 2023. They were divided into two groups: one using…
A Pilot Study on Gratitude Journaling for Black Breast Cancer Survivors Background Breast cancer survivorship shows significant health disparities, especially in Black women, who have a 40% higher death rate compared to White women. These issues are worsened by other health problems and psychosocial challenges, leading to increased stress and lower well-being. This pilot study…
A Mobile-Based Study on Screening for Major Depressive Disorder Overview This study aims to explore how effective and practical it is to screen for Major Depressive Disorder (MDD) using mobile technology. Early detection and treatment of MDD can significantly reduce its impact on society. Study Design The research will involve a randomized controlled trial (RCT)…
Effect of Goal-Directed Perceptual-Motor Exercise on Children with Learning Difficulties Study Overview This study explored how goal-directed perceptual-motor exercises can help children with Specific Learning Disorder (SLD). These exercises improve coordination, decision-making, and engagement in physical activities. Research Details A total of 38 children with SLD participated in this randomized clinical trial from September 2021…
Effect of Integrating Pediatric Tuberculosis Services into Child Healthcare in Africa Introduction Pediatric tuberculosis (TB) is often underdiagnosed, which is a serious issue. The INPUT trial studied how combining TB services with child healthcare can improve TB detection in children under 5 years old. Methods We compared two approaches: the standard care, where TB services…
Cost-Effectiveness of Integrating Pediatric Tuberculosis Services in Africa Background In 2021, over one million children got tuberculosis (TB), leading to 214,000 deaths. This is mainly due to poor diagnosis and treatment. Most high-burden countries have centralized TB services, making it hard to access care. To improve TB detection and treatment in children, the World Health…
Antibiotic Use and Cognitive Decline in Older Adults Study Overview This study investigates the relationship between antibiotic use and cognitive decline in healthy older adults. It focuses on how antibiotics may affect memory and thinking skills over time. Key Findings Antibiotic use did not increase the risk of developing dementia or cognitive impairment. Data was…
Phase II Study of Defactinib (VS6063) in Patients With Tumors With NF2 Loss Overview of the Study The NCI-MATCH trial focused on patients with various cancers, assigning them targeted therapies based on genetic changes found in their tumors. This study specifically looked at tumors with neurofibromatosis 2 (NF2) mutations, which are sensitive to a treatment…
Levofloxacin Preventive Treatment in Children Exposed to MDR Tuberculosis Background About 2 million children under 15 worldwide are infected with multidrug-resistant (MDR) tuberculosis. Each year, around 30,000 new cases of MDR tuberculosis occur. There is a lack of solid evidence from trials on how to prevent tuberculosis in children exposed to MDR tuberculosis. Study Overview…