Levofloxacin for Preventing Drug-Resistant Tuberculosis in Vietnam Background Preventing drug-resistant tuberculosis is a major global health goal. There have been few studies on how to effectively treat tuberculosis infections in people close to those with drug-resistant tuberculosis. Methods We conducted a well-structured clinical trial where participants received either levofloxacin or a placebo for 6 months…
Effectiveness of Internet-Based Acceptance and Commitment Therapy for Health Care Professionals Background Health care professionals often experience psychological distress, which can negatively affect patient care. Internet-based acceptance and commitment therapy (iACT) is a cost-effective and accessible way to improve mental health. However, there is not enough evidence on its effectiveness for health care professionals. Objective…
Findings From the Todurujo na Kadurok (Empowering Youth) HIV Self-Testing and Edutainment Comic Trial Introduction Humanitarian areas often lack access to HIV self-testing (HIV-ST). Methods We conducted a trial to test three approaches: Arm 1: HIV-ST alone Arm 2: HIV-ST with edutainment comics Arm 3: Edutainment comics only These were compared to the standard care…
A Study on Toripalimab for Advanced Cervical Cancer Objective The goal of this study was to evaluate how effective and safe toripalimab is when used with platinum-based chemoradiotherapy for treating locally advanced cervical cancer. Methods We included 82 patients diagnosed with locally advanced cervical cancer at Tianjin Medical University Cancer Institute and Hospital from May…
Health Economic Evaluation of a Diabetes Intervention in Nepal Background Type 2 diabetes prevention is a major health issue in low and middle-income countries like Nepal. This study looked into the cost-effectiveness of a health behaviour intervention compared to regular care for managing diabetes in a community setting. Methods We randomly assigned 30 groups of…
Study on Rezvilutamide vs. Bicalutamide for Prostate Cancer Overview The CHART trial (NCT03520478) was a phase 3 study comparing rezvilutamide (REZ) with bicalutamide (BIC) in patients with high-volume metastatic hormone-sensitive prostate cancer (mHSPC) receiving androgen deprivation therapy (ADT). The study found that REZ combined with ADT led to better survival rates and less disease progression…
Understanding the ISCHEMIA Trial Findings Background The ISCHEMIA Trial explored how stress-induced ischemia relates to coronary artery disease (CAD) severity. Factors influencing this relationship include: Intensity of stress during testing Type of stress test used History of heart attacks Blood flow from collateral vessels Characteristics of plaque Microvascular health Coronary blood vessel tone Genetic factors…
Immediate Effects of Kinesio Taping on Pain, Proprioception, and Posture Background Round shoulder posture (RSP) occurs when shoulders are positioned forward due to weak and tight muscles. This can lead to Subacromial Impingement Syndrome (SIS), causing pain during certain movements. This study looks at how Kinesio taping (KT) affects pain, body awareness (proprioception), and posture…
Effect of Aerobic Training on Obesity Background Obesity is a major health issue worldwide, leading to various health problems, including heart disease. This study looks at how low- and moderate-intensity aerobic training can affect body composition and health markers in severely obese patients. Methods Forty severely obese patients participated in a six-week study. They were…
Effects of Synbiotic Supplementation on Bone and Metabolic Health in Postmenopausal Women Overview This study explores how a synbiotic supplement can help improve bone and metabolic health in Caucasian postmenopausal women. The OsteoPreP trial will last for 12 months and aims to see if this supplement can prevent bone loss and improve overall health. Study…
Efficacy of ETB-F01 in Patients with Respiratory Symptoms Study Overview Respiratory issues are common and can lead to serious health problems. This study focuses on a treatment called ETB-F01, which contains heat-killed Akkermansia muciniphila strain EB-AMDK19. We wanted to see if it helps reduce respiratory symptoms. Trial Details This was a randomized, double-blind trial involving…
Enhancing Nutrition Therapy with Glucose Monitoring for Prediabetes Background and Objectives Prediabetes increases the risk of serious health issues like type 2 diabetes and heart disease. Early detection and lifestyle education are essential to prevent these complications. This study explored how real-time feedback from continuous glucose monitoring (CGM) can improve individualized nutrition therapy (INT) for…
Cognitive Benefits of Folic Acid Supplementation During Pregnancy Study Overview This study explores how folic acid during pregnancy affects cognitive development in children. It focuses on the ZFP57 gene, which plays a key role in gene regulation and is influenced by folate levels. Research Methods We analyzed data from a previous clinical trial called FASSTT,…
Effectiveness of Intra-Oral Botulinum Toxin Injection for Myofascial Pain Study Overview This study compares two methods of injecting botulinum toxin for treating myofascial pain in the masseter muscle: intra-oral and extra-oral techniques. Objective The goal was to see which injection method is more effective in reducing pain and improving quality of life for patients with…
Economic Evaluation of ASCOT Trial for Eye Trauma Background In the UK, around 5,000 people suffer eye injuries each year, with 250 resulting in permanent blindness. This study looks at the cost-effectiveness of using an adjunctive steroid treatment during surgery for patients with open globe trauma compared to standard treatment. Methods This evaluation was part…
Noninvasive Early Identification of Clinical Benefits from Immune Checkpoint Inhibition Study Overview This study focuses on how to quickly identify patients with non-small cell lung cancer (NSCLC) who benefit from immune checkpoint inhibitors (ICIs). Out of 328 patients screened, 101 were enrolled, and 83 were evaluated for ICI effectiveness. Among these, 56 patients showed durable…
Wearable Telemedicine for Heart Disease Management in Elderly Patients Background Chronic coronary heart disease (CHD) is common in older adults and is a leading cause of death and health issues. Study Purpose This study explored how effective telemedicine is for managing elderly patients with CHD using remote monitoring. Methods We enrolled 1,248 elderly patients with…
The Effect of Vildagliptin vs. Metformin on Liver Fat in Type 2 Diabetes Patients Study Overview This study investigated how two medications, vildagliptin and metformin, affect liver fat in patients recently diagnosed with type 2 diabetes (T2D). We used the Hepatic Steatosis Index (HSI) and ultrasound to measure liver health. Research Details Participants: 246 patients…
Phase 2A Trial of Nicotinamide for Early Alzheimer Disease Study Overview This study tested nicotinamide, a coenzyme that may help reduce tau phosphorylation in early Alzheimer Disease (AD). Trial Details Type: Double-blind, randomized, placebo-controlled Duration: 48 weeks Dose: 1,500 mg of nicotinamide, taken twice daily Participants 47 participants were enrolled, aged around 74 years, with…
Facing Depression: A New Approach to Treatment Study Overview: This clinical trial aims to improve depression treatment by evaluating a new training method that combines cognitive restructuring with facial expression techniques. The focus is on how our thoughts and physical expressions can impact depression. Background Depression is often linked to negative thinking patterns. Current treatments,…