Factors predicting long-term outcomes following physiotherapy in patients with subacromial pain syndrome: a secondary analysis ABSTRACT Patients with shoulder complaints often undergo physiotherapy, but it’s unclear which factors predict long-term outcomes. This study aims to identify these factors to help patients make informed treatment decisions, avoid ineffective treatments, and minimize chronic pain risk. AIM This…
Clinical Relevance of Combined Treatment with Exercise in Chronic Low Back Pain Study Summary Chronic low back pain (CLBP) is a common health issue, and this study aimed to evaluate the impact of exercise alone or combined with manual therapy and kinesiotherapy on pain sensitivity, disability, kinesiophobia, self-efficacy, and catastrophizing in CLBP patients. Key Findings…
Study Title: Biomarker-guided Acute Kidney Injury Risk Assessment Highlights of the Study: • Addressed the need for preventative measures against acute kidney injury (AKI) in surgical patients. • Assessed the impact of intraoperative fluid management on AKI in female breast cancer patients undergoing autologous breast reconstruction. • Utilized novel urinary biomarkers (TIMP-2 and IGFBP-7) for…
SomaLogic Proteomics Reveals New Biomarkers in NASH Key Findings from Clinical Trial Non-alcoholic Fatty Liver Disease (NAFLD) and Non-alcoholic Steatohepatitis (NASH) are metabolic diseases with no approved therapies. We conducted a Phase 2a trial (NCT03248882) with Clesacostat (PF-05221304), an acetyl coA carboxylase inhibitor (ACCi), in patients with NAFLD/NASH. Our SomaLogic serum proteome profiling identified potential…
Stroke Risk Reduction in Atrial Fibrillation Through Pharmacist Prescribing: A Randomized Clinical Trial Key Findings: Pharmacist-led oral anticoagulation therapy (OAC) prescription significantly increased the delivery of stroke risk reduction therapy in individuals with atrial fibrillation (AF). Guideline-concordant OAC use at 3 months occurred in 92.3% of patients in the early intervention group vs 56.1% in…
Preoperative Promestriene for Hysteroscopy: A Randomized Clinical Trial Objective In hysteroscopy, complications like false passage creation and uterine perforation can lead to procedure suspension, causing delays in diagnosing uterine pathology. This study aimed to assess the impact of using promestriene for cervical preparation on complications in postmenopausal women undergoing surgical hysteroscopy. Methods A double-blind clinical…
Longitudinal Phospho-tau217 Predicts Amyloid Positron Emission Tomography in Asymptomatic Alzheimer’s Disease Practical Solutions and Value Highlights Value of Blood-based AD Biomarkers Blood-based AD biomarkers, such as plasma P-tau217, are increasingly used in clinical trials as a screening tool. Utility of Electrochemiluminescence Immunoassay An electrochemiluminescence (ECL) immunoassay was assessed for its ability to predict brain amyloid…
Characterizing Clinical Progression in Cognitively Unimpaired Older Individuals with Brain Amyloid: Results from the A4 Study ABSTRACT Researchers studied the sensitivity of Clinical Dementia Rating (CDR) in measuring pre-symptomatic Alzheimer’s disease progression in the A4 study. They examined specific CDR boxes and their changes over time in individuals with brain amyloid. SETTING The A4 study…
Subgroup analyses from patients with pre-treated metastatic colorectal cancer receiving trifluridine/tipiracil: results of the TALLISUR trial Key Findings Trifluridine/tipiracil (FTD/TPI) showed improved progression-free and overall survival for pre-treated metastatic colorectal cancer patients. The treatment also maintained quality of life for the patients. Study Details The TALLISUR trial in Germany assessed the efficacy, safety, and quality…
Evaluation of Staining Propensity of Silver Diamine Fluoride With and Without Potassium Iodide in Children (Project Healthy Smiles): Protocol for a Randomized Controlled Trial ABSTRACT Background: Silver diamine fluoride (SDF) is a cost-effective way to reduce sensitivity and stop cavities, but it causes black staining. Potassium iodide (KI) treatment with SDF may reduce this staining,…
Assessing Patient Perspectives and Health Equity in Digital Cancer Symptom Management Summary Researchers evaluated Symptom Care at Home (SCH), a digital system for managing cancer symptoms, to assess patient engagement, user satisfaction, and intervention benefits across different patient groups. The study aimed to reduce disparities in symptom care outcomes. Key Findings Participants using SCH reported…
Diagnostic Accuracy of AI-Based Symptom Checker and Web-Based Self-Referral Tool in Rheumatology Key Findings The study aimed to evaluate the diagnostic accuracy of a mobile artificial intelligence (AI)-based symptom checker (Ada) and a web-based self-referral tool (Rheport) in identifying inflammatory rheumatic diseases (IRDs). Results showed that both tools demonstrated overall diagnostic accuracies of 52% to…
Diagnostic Accuracy of Mental Health Screening Tools After Mild Traumatic Brain Injury JAMA Netw Open. 2024 Jul 1;7(7):e2424076. doi: 10.1001/jamanetworkopen.2024.24076. Importance: Mental health disorders are common after mild traumatic brain injury (mTBI) and can worsen postconcussive symptoms and disability. Detecting these disorders early can improve clinical outcomes, but the accuracy of mental health screening tools…
The Effect of Histopathologic Analysis and Tissue Cultures on Cellulitis Management Background In cases of cellulitis, it can be challenging to accurately diagnose due to the lack of a definitive diagnostic method, leading to potential misdiagnosis of other inflammatory disorders as cellulitis. Objective This study aimed to assess the usefulness of skin biopsy and tissue…
Effectiveness of Culturally Tailored HIV Intervention in Promoting PrEP Among Black Women Key Findings: In a randomized clinical trial, a culturally-tailored HIV intervention called E-WORTH significantly increased awareness of PrEP and willingness to use PrEP among Black women in community supervision programs in New York City. Practical Solutions: These findings highlight the need for more…
Study on Preoperative Nutrition for Cancer Surgery Patients Key Findings Comparing the effects of preoperative nutrition drink and overnight parenteral nutrition on muscle metabolism in patients undergoing major gastrointestinal cancer surgery. Results The study found that the preoperative nutrition drink had limited impact on muscle metabolism, particularly in glucose metabolism. On the other hand, overnight…
Sleep-Loss Related to Itch in Atopic Dermatitis: Assessing Content Validity and Psychometric Properties of a Patient-Reported Sleep-Loss Rating Scale Abstract Background: Sleep loss is a significant issue for people with atopic dermatitis (AD) due to itch. Addressing itch to improve sleep is a crucial aspect of AD treatment. Methods: Interviews were conducted with 21 adults…
Effects of a Web Application for Rotator Cuff-Related Shoulder Pain Protocol for an Open-Label Randomised Controlled Trial Introduction: Rotator cuff-related shoulder pain (RCRSP) is a common cause of shoulder pain. Exercise is the main treatment, but long-term adherence can be challenging. This study evaluates the effects of adding video animations to a traditional exercise programme.…
Comparison of Clinical Outcomes: Corneal Wavefront- vs. Topography-Guided LASIK Study Overview This study compared the outcomes of myopia correction using corneal-wavefront-guided (CWG) LASIK with AMARIS 1050S and corneal-topography-guided (CTG) LASIK with WaveLight EX500. Key Findings After 3 months postoperatively: Spherical and coma aberrations were significantly lower in the WaveLight group compared to the AMARIS group.…
Study Title: The TABANETOC Trial Objective: Evaluating the Anti-Neoplastic Effects of Tinzaparin in EOC Patients Background: Tinzaparin, a low-molecular weight heparin (LMWH), has demonstrated anti-neoplastic properties in animal models and in vitro studies of human cancer cell lines. Reduction in CA-125 levels during neoadjuvant chemotherapy (NACT) in patients with epithelial ovarian cancer (EOC) is associated…