Effectiveness of Extracorporeal Shock Wave Therapy on Functional Ability in Grade IV Knee Osteoarthritis Summary Extracorporeal shockwave therapy (ESWT) is a non-invasive treatment for knee osteoarthritis (OA). This study aimed to assess the effects of ESWT on functional ability in grade IV KOA patients. The trial showed that adding ESWT to conventional physiotherapy (CPT) significantly…
Reliability of Impedance Spectroscopy in Occlusal Caries Detection Key Findings: The study compared the performance of alternating current impedance spectroscopy (ACIST) with digital radiograph (DR) and ICDAS-II in detecting occlusal carious lesions. Results showed excellent agreement in the different groups, with ACIST proving to be a reliable tool for detecting occlusal caries in dentin. Visual-tactile…
ObiVas Study Overview Introduction ANCA-associated vasculitis (AAV) is a condition where relapses can lead to severe organ damage, necessitating prolonged immunosuppressive therapy. Rituximab, the current standard of care, may not always be effective and is linked to a high relapse risk. Obinutuzumab is a potential alternative with the ability to achieve better tissue B cell…
Altered States of Consciousness Caused by Mindfulness-Based Programme: Results from a Randomised Controlled Trial Background Mindfulness-based programmes (MBPs) have shown positive effects on mental health. There is evidence that MBPs may also lead to significant changes in waking consciousness. This study aimed to explore the causal role of MBPs in different types of altered states…
Opioid-sparing Effect of Erector Spinae Plane Block and Intravenous Dexmedetomidine for Obese Patients with Obstructive Sleep Apnea: A Randomized Controlled Trial Objective: This study aimed to evaluate the impact of erector spinae plane block (ESPB) and intravenous (IV) dexmedetomidine in reducing opioid consumption after bariatric surgery and their effects on post-operative recovery, pain relief, and…
Key Findings from Clinical Trial Practical Solutions for Chronic Low Back Pain Management Participants with opioid-treated chronic low back pain (CLBP) reported various pain management strategies as helpful. Medication, physical activity, and stretching remained stable over time. However, passive management strategies like body position and thermal application declined, while psychological strategies showed increased usage. Value…
Community Health Worker-Led Household Screening and Management of Neonatal Hyperbilirubinemia in Rural Bangladesh: A Cluster Randomized Control Trial Protocol Abstract Background: In low- and middle-income countries (LMIC) like Bangladesh, many newborns with hyperbilirubinemia do not receive timely treatment, resulting in a significant impact on neurologic health and mortality. This trial aims to assess the effectiveness…
Low Dose Morphine for Dyspnea in Acute Respiratory Failure: OpiDys Trial Practical Solutions and Value Morphine is commonly used to alleviate dyspnea, but its effectiveness in ICU patients with acute respiratory failure was uncertain. The OpiDys trial aimed to assess the benefits and risks of low-dose morphine in this specific patient population. Patients with severe…
Pneumatic Retinopexy for Primary Rhegmatogenous Retinal Detachment: Real-World Outcomes Key Findings: 84.3% of patients achieved primary anatomic reattachment 100% of patients achieved final anatomical reattachment after pars plana vitrectomy Best corrected visual acuity improved significantly after surgery Main cause of failure was related to missed retinal breaks Mean NEI-VFQ 25 composite score was 93.9% at…
Serplulimab Combined Therapy for Metastatic Pancreatic Adenocarcinoma Practical Solutions and Value Patients with metastatic pancreatic adenocarcinoma face a poor prognosis despite chemotherapy. This study aims to evaluate the effectiveness and safety of a combined treatment approach using PD-1 blockade, gemcitabine plus nab-paclitaxel chemotherapy, and stereotactic body radiotherapy (SBRT). This is a phase II clinical trial…
Distal Ventricular Pacing for Drug-Refractory Mid-Cavity Obstructive Hypertrophic Cardiomyopathy: A Randomized, Placebo-Controlled Trial of Personalized Pacing Key Findings Patients with severe symptoms from mid-cavity obstructive hypertrophic cardiomyopathy benefited from personalized pacing (PPoP) with reductions in obstruction and improved exercise performance. Practical Solutions Our AI-driven platform, DocSym, consolidates ICD-11 standards, clinical protocols, and research for easy…
Study Protocol: Qing-Xin-Jie-Yu Granules for Coronary Artery Disease Introduction Managing stable coronary artery disease (SCAD) is challenging despite available treatments. Intermediate coronary lesion (ICL) is a critical stage of SCAD, but current therapies have limitations. Qing-Xin-Jie-Yu Granules (QXJYG) may offer benefits as a complementary therapy due to its anti-platelet, anti-inflammatory, and lipid-lowering effects. Materials and…
The Effect of Itraconazole on the Pharmacokinetics of ACT-1004-1239 Key Findings: CYP3A4 is an important enzyme in drug metabolism and interactions. ACT-1004-1239 is a promising treatment for demyelinating diseases and is mainly metabolized by CYP3A4. This study looked at how the strong CYP3A4 inhibitor itraconazole affected the pharmacokinetics of ACT-1004-1239 in healthy male subjects. The…
No Improvement in Alcohol Screening and Brief Intervention Rates among Aboriginal Community Controlled Health Services Key Findings Results from a cluster randomised trial showed that providing training and support to Aboriginal Community Controlled Health Services (ACCHSs) did not lead to improvements in alcohol screening and brief intervention rates among wait-list control services. Practical Solutions Future…
Comparison of Case-Based and Lecture-Based Learning in Dental Fluorosis Diagnostic Ability with Visual Analog Scale Assessment Objective This study aimed to compare the impact of case-based learning (CBL) versus lecture-based learning (LBL) on dental students’ clinical decision-making regarding dental fluorosis (DF) severity using Visual Analog Scale (VAS) scoring. Methods Eighty first-year graduate dental students were…
Anti-inflammatory therapy with nebulized dornase alfa for severe COVID-19 pneumonia: a randomized unblinded trial Key Findings Dornase alfa, when administered through nebulization, effectively reduced systemic inflammation in severe COVID-19 pneumonia patients, as shown by a 33% reduction in C-reactive protein (CRP) levels compared to standard care. Practical Solutions The use of dornase alfa led to…
Equitable Care for Hypertension: Blood Pressure and Patient-Reported Outcomes of the RICH LIFE Cluster Randomized Trial Key Findings RICH LIFE study compared two interventions for hypertension control: standard of care plus (SCP) and collaborative care/stepped care (CC/SC). Both groups achieved significant blood pressure control rates at 12 months, with no significant differences between racial and…
Integration of Immuno-MESODEC Study into Epithelioid Malignant Pleural Mesothelioma Treatment Key Points Malignant pleural mesothelioma (MPM) is a very aggressive cancer with a poor prognosis. The Immuno-MESODEC study aims to integrate PD-L1 inhibitor atezolizumab and WT1/DC vaccination into the first-line treatment for epithelioid MPM patients. It is a multicenter, single-arm, phase I/II trial designed to…
Mindful Self-Compassion Smartphone Intervention for Worker Mental Health Practical Solutions and Value Highlights: Mental health issues among workers in Japan lead to significant losses for companies. Workers often face time constraints, limiting their access to psychological support. To address this, a smartphone app was developed to provide brief guided mindfulness meditation (MM) and self-compassion meditation…
The Efficacy of Early Office Hysteroscopy in Preventing Intrauterine Adhesions after Abortion: A Randomized Controlled Trial BMC Womens Health. 2024 Jul 13;24(1):400. doi: 10.1186/s12905-024-03247-0. Background: Intrauterine adhesions (IUA) are a common issue after intrauterine surgery and abortions, impacting fertility. This study aimed to assess if early office hysteroscopy can prevent IUA. Methods: The trial included…