Bone Pain and Survival Among Patients With Metastatic, Hormone-Sensitive Prostate Cancer: A Secondary Analysis of the SWOG-1216 Trial Summary: The study aimed to compare survival outcomes among patients with metastatic, hormone-sensitive prostate cancer (MHSPC) based on the presence or absence of baseline bone pain at diagnosis. Methodology: The analysis used patient-level data from the SWOG-1216…
Relaxation Intervention for Diabetic Foot Ulcer Healing Study Overview A pilot study was conducted to assess the feasibility and acceptability of a relaxation intervention for diabetic foot ulcer (DFU) healing. The study compared progressive muscle relaxation with guided imagery (experimental group) to a neutral guided imagery placebo (active control group) and a group that did…
Clinical Trial Results: Interactive Walkway for Fall-Risk Biomarkers in the Elderly Key Findings: Study compared zolpidem and suvorexant in elderly subjects to assess the sensitivity of the Interactive Walkway (IWW) in measuring walking adaptability and fall risk. Results indicated that zolpidem led to decreased performance in walking adaptability, Timed-Up-and-Go test, and body sway, while suvorexant…
Daratumumab in transplant-eligible patients with newly diagnosed multiple myeloma: final analysis of clinically relevant subgroups in GRIFFIN Blood Cancer J. 2024 Jul 8;14(1):107. doi: 10.1038/s41408-024-01088-6. The GRIFFIN study (NCT02874742) investigated daratumumab plus lenalidomide/bortezomib/dexamethasone (D-RVd) in newly diagnosed multiple myeloma (NDMM) patients who are eligible for transplant. The study’s final analysis focused on subgroups, including those…
Possible Protective Effect of Rosuvastatin in Chemotherapy-Induced Cardiotoxicity in HER2 Positive Breast Cancer Patients: A Randomized Controlled Trial Summary Chemotherapy in HER2 positive breast cancer patients can lead to cardiotoxicity. This study investigated the potential protective effect of rosuvastatin against chemotherapy-induced cardiotoxicity. The results showed that rosuvastatin-treated group had significantly lower decline in LVEF, lower…
Duloxetine Effectiveness in Preventing Taxane-Related Neuropathy Key Findings Paclitaxel chemotherapy can lead to long-lasting neuropathy. However, a double-blind randomized trial revealed that duloxetine is a potentially effective medication for preventing both subjective and objective neuropathy in breast cancer patients undergoing paclitaxel treatment. Practical Solutions The study found that daily administration of duloxetine at specific doses…
Frontloading Home Physical Therapy Visits for Patients With Heart Failure: A Multi-center Randomized Controlled Trial Abstract Frontloading home care visits were investigated for their impact on function in persons with heart failure (HF) in a prospective multi-center randomized controlled trial. A total of 82 ambulatory patients participated, with one group receiving frontloaded visits and another…
Frequency of Red Blood Cell Allo-Immunization in Patients Undergoing Blood Transfusion at the Uganda Cancer Institute ABSTRACT There is limited data on red blood cell (RBC) alloimmunization in patients with cancer in sub-Saharan Africa (SSA). We examined the frequency of RBC alloimmunization in transfused patients with cancers in Uganda. METHODS A randomized control trial was…
Study Summary Comparison of Sedation Drugs in Elderly Patients During Gastrointestinal Endoscopy Researchers compared the use of remimazolam besylate and a combination of etomidate and propofol for sedation in elderly patients undergoing gastrointestinal endoscopy. The study aimed to assess the effectiveness and safety of these sedation methods. Key Findings Remimazolam besylate showed comparable safety and…
Phase I Thorough QT/QTc Study of Avacopan in Healthy Participants Study Details A phase I thorough QTc study evaluated avacopan’s effect on cardiac repolarization in healthy participants. The study included both therapeutic and supratherapeutic doses of avacopan, as well as placebo and positive controls. Key Findings The study found that avacopan did not have a…
Digital Technology Revolutionizing Mandibular Fracture Treatment Comparative Analysis of Patient-Specific Plates and Conventional Titanium Plates Objective: To assess the clinical effectiveness of patient-specific plates utilizing digital technology in treating mandibular fractures compared to conventional titanium plates. Materials and Methods: Twenty patients with mandibular fractures were included and randomly assigned to study or control groups. The…
Effects of Discontinuing Antihypertensive Treatment in Nursing Home Residents with Dementia Key Findings Discontinuing antihypertensive treatment in nursing home residents with dementia did not significantly reduce neuropsychiatric symptoms or improve quality of life compared to usual care. Study Details The study involved 205 participants with moderate-to-severe dementia and systolic blood pressure ≤160 mmHg. They were…
Effect of Metformin on Gut Microbiota Imbalance in T2DM Patients and the Value of Probiotic Supplementation ABSTRACT PURPOSE: This study aimed to investigate the impact of metformin on gut microbiota imbalance in patients with type 2 diabetes mellitus (T2DM) and the potential benefits of probiotic supplementation. METHODS: 84 newly diagnosed T2DM patients were randomly assigned…
Clinical Trial Results: Transvaginal Natural Orifice Transluminal Endoscopic Surgery for Ovarian Cysts Key Findings The study aimed to assess the safety and feasibility of using transvaginal natural orifice transluminal endoscopic surgery (vNOTES) for managing ovarian cysts. The results showed that vNOTES was not inferior to conventional laparoscopy (CL) in terms of adnexectomy or ovarian cystectomy.…
Participants’ Perspectives on Weight Loss Intervention Trial Before Colorectal Cancer Surgery Key Findings Patients with excess weight awaiting colorectal cancer surgery were motivated by the offer of structured weight loss support that could potentially improve their surgical outcomes. However, concerns about the potential unpalatability of the intervention diet and side effects were also expressed. Positive…
Maintenance Therapy with Anlotinib for Advanced Non-Small-Cell Lung Cancer Key Findings Maintenance therapy with anlotinib after platinum-based chemotherapy showed a median progression-free survival of 5.95 months and a median overall survival of 18.60 months in patients with advanced non-small cell lung cancer. Results Out of 23 patients, 19 had stable disease, 1 had a partial…
Effectiveness of HIV Self-Testing in Assisted Partner Services (APS-HIVST Study) Practical Solutions and Value Assisted partner services (APS) is a successful strategy for increasing HIV testing, new diagnoses, and linkage to care among partners of people living with HIV (PLWH). However, it can be resource intensive. This study aimed to assess the effectiveness of offering…
Bronchoscopy with and without Needle-Based Confocal Laser Endomicroscopy for Peripheral Lung Nodule Diagnosis: Protocol for a Multicentre Randomised Controlled Trial (CLEVER Trial) Introduction Despite technological advances, bronchoscopic peripheral lung nodule analysis still faces limitations due to frequent mispositioning. Needle-based confocal laser endomicroscopy (nCLE) provides real-time microscopic feedback on needle positioning, potentially improving sampling location and…
HAP-FAST Feasibility Study Key Points: • Evaluating the clinical impact of low-dose CT scans and rapid molecular sputum analysis for suspected non-ventilator-associated hospital-acquired pneumonia (nv-HAP). • Incorporating a pilot trial, qualitative study, costing analysis, and immune-pathophysiology investigation. • Participants recruited from four acute hospitals in the Northwest of the UK. • Assessing trial processes, outcome…
Comparing Autologous Blood, Corticosteroid, and Combined Injection for Lateral Epicondylitis Treatment Background Lateral epicondylitis is a common forearm condition, and this study compared the effectiveness of autologous blood (AB) injection, corticosteroid (CS) injection, and a combined injection of both in treating the condition. Materials and Methods 120 patients were divided into three groups for different…