Web-Based Cognitive Behavioral Treatment for Bulimia Nervosa: A Randomized Clinical Trial Practical Solutions and Value Despite effective treatments for bulimia nervosa (BN), many individuals do not receive evidence-based therapies. Integrating digital interventions into routine care can reach more patients and reduce the clinical burden of BN. A web-based cognitive behavioral self-help intervention was evaluated for…
Prediction of Long-Term Treatment Outcomes for Diabetic Macular Edema Using a Generative Adversarial Network ABSTRACT The study aimed to use generative adversarial networks (GANs) to analyze optical coherence tomography (OCT) images for predicting diabetic macular edema outcomes after long-term treatment. METHODS Diabetic macular edema (DME) eyes (n = 327) from a randomized controlled trial underwent…
Can Biomarkers Predict Ventilator-associated Pneumonia in Patients After Cardiac Arrest? Summary Ventilator-associated pneumonia (VAP) is a common complication after cardiac arrest, but diagnosing it accurately remains a challenge. This study aimed to evaluate the usefulness of biomarkers in diagnosing VAP in post-cardiac arrest patients. Study Design This study was part of the ANTHARTIC trial, a…
Impact of Coenzyme Q10 as Adjuvant Therapy to Letrozole Spermiogram Results and Sex Hormone Levels in Iraqi Men with Infertility Background: Infertility affects about 15% of reproductive-age couples globally. The clinical trial aimed to assess the effects of adding Coenzyme Q10 (CoQ10) to letrozole on the spermiogram and sex hormone levels in men with idiopathic…
Peer2Me: A Peer-Supported Program for AYA Cancer Patients Study Protocol of a Randomised Trial Using a Comprehensive Cohort Design Background: Young adult cancer patients often experience psychological distress and unmet support needs. The Peer2Me intervention aims to provide peer support to AYA cancer patients to enhance self-efficacy and coping with the disease. Methods: The study…
Effect of Cuff Inflation with Lidocaine, Saline, and Air on Tracheal Tube Cuff Pressure during Laparoscopic Resection of Colorectal Neoplasms: A Randomized Clinical Trial BMC Anesthesiol. 2024 Jul 1;24(1):216. doi: 10.1186/s12871-024-02606-6. Background: This trial aimed to determine if inflating tracheal tube cuffs with normal saline or lidocaine can prevent an increase in cuff pressure and…
Evaluating Subthreshold Micropulse Laser Combined with Ranibizumab for Diabetic Macular Edema Study Overview A study was conducted to assess the effectiveness and safety of using subthreshold micropulse laser (SMPL) in combination with ranibizumab for treating diabetic macular edema (DME). Patients were randomly assigned to receive either ranibizumab monotherapy or the combination therapy. Key Findings Both…
Feasibility of Cardiac Brief Intervention for ST-elevation Myocardial Infarction Patients Key Points: Patients often experience emotional distress and misconceptions after a heart attack. This study aims to assess the feasibility of providing a nurse-led, 20-minute emotional and educational support discussion, along with a memory-aid leaflet, to patients before discharge from the hospital. Participants will be…
Efficacy, Safety, Satisfaction, Adherence to Treatment With Nano-Formulated Cysteamine Tranexamic Acid Cream to Treat Melasma Key Findings An innovative cream combining cysteamine and tranexamic acid (TXA) showed significant improvement in treating subjects with epidermal melasma. Results Continuous improvement in melasma was observed, with modified Melasma Area and Severity Index (mMASI) scores improving by 40%, 57%,…
Textured Insoles Feasibility Trial for Children with Motor Coordination Issues Summary Textured insoles may improve balance measures in children with motor coordination issues, but do not show significant impact on endurance measures. The trial aimed to assess the feasibility of conducting a randomised controlled trial for children with motor coordination issues and to evaluate the…
Re-evaluating Insomnia Severity Index in Clinical Trials Key Findings and Practical Solutions Background: The Insomnia Severity Index (ISI) is commonly used to assess insomnia severity, but different research findings have led to variations in defining meaningful within-individual change (MWIC) for treatment response. Methods: We analyzed data from two large clinical trials of lemborexant to improve…
Comparing Performance of Primary Care Clinicians in the Interpretation of SPIROmetry with or without Artificial Intelligence Decision Support Software (SPIRO-AID): A Protocol for a Randomised Controlled Trial ABSTRACT Spirometry, a lung function test, is crucial for diagnosing and monitoring chronic lung disease. However, its interpretation in primary care varies in quality and accuracy. This study…
Predictors of long-term progression-free survival in ovarian cancer patients treated with niraparib Key Findings In a study on advanced ovarian cancer patients receiving niraparib maintenance therapy, certain factors were found to be associated with long-term progression-free survival (≥2 years). Practical Implications The study identified that patients with BRCA1/2 mutation/homologous recombination-deficiency status, FIGO stage III, and…
Exploring Relations Between Unique Patient Characteristics and Virtual Reality Immersion Level on Anxiety and Pain in Patients Undergoing Venipuncture: Secondary Analysis of a Randomized Control Trial ABSTRACT Virtual reality (VR) has been widely studied as a digital tool for managing acute pain and anxiety in pediatric patients during medical procedures. This study investigates how specific…
Exercise-Induced Oxygen Desaturation and Arterial Stiffness in COPD Patients Study Overview This study aimed to investigate the impact of exercise-induced oxygen desaturation (EID) on arterial stiffness in individuals with COPD. Patients underwent the 6-minute walk test (6-MWT) with continuous monitoring of blood oxygen saturation (SpO2) to assess the acute effects of exercise on arterial stiffness.…
Study Title: Calcium Dibutyryl Adenosine Cyclophosphate Enhances the Effect of Metoprolol in Treating Older Adults With Heart Failure Combined With Arrhythmia Objective: To investigate the effectiveness and safety of combining calcium dibutyryl adenosine cyclophosphate (dbcAMP-Ca) with metoprolol in treating older adults with heart failure and arrhythmia. Methods: – 102 elderly patients were enrolled and randomly…
Low Pressure versus Standard Pressure Pneumoperitoneum in Laparoscopic Appendectomy: A Randomized Controlled Trial Key Findings The use of low pressure pneumoperitoneum did not reduce the incidence of abdominal pain in patients who had laparoscopic appendectomy. Patients with acute appendicitis can be treated with either low or normal pressure pneumoperitoneum depending on the experience of the…
Efficacy and Safety of Combination Therapy for Schistosomiasis in Kenyan Children Introduction Reliance on praziquantel for treating schistosomiasis may lead to drug resistance. We evaluated the efficacy and safety of combining praziquantel with artesunate plus sulfalene-pyrimethamine in Kenyan children with schistosomiasis. Methods 426 children aged 7-15 were randomly assigned to receive praziquantel alone, artesunate plus…
Empagliflozin Reduces Ventricular Arrhythmias in Type 2 Diabetes Patients Study Overview Sodium-glucose cotransporter 2 (SGLT2) inhibitors like empagliflozin have shown benefits in reducing heart failure and cardiovascular death in type 2 diabetes patients. This study aimed to investigate the effects of empagliflozin on ventricular arrhythmias in patients with type 2 diabetes who were treated with…
Exploring the Impact of Link Workers on Multimorbidity in Deprived Communities Overview An exploratory trial was conducted to assess the feasibility, impact, and cost effectiveness of using link workers to connect individuals with multiple health conditions to non-clinical supports in deprived urban communities. The study aimed to evaluate the benefits of this approach on health…