Efficacy

The Effect of Mandala Coloring on Happiness in Veterans with PTSD during Covid-19 Pandemic Key Findings Art-making, particularly mandala coloring, showed significant improvement in happiness scores among male veterans with PTSD compared to free coloring. Practical Solutions Integrating art therapy, such as mandala coloring, into conventional treatments for veterans with PTSD can enhance their overall well-being and happiness. Value Art therapy, specifically mandala coloring, offers a valuable and effective addition to the treatment of veterans with PTSD, contributing to their mental and emotional well-being. ➡️➡️➡️

Study Protocol for the MIND-PD Study A Randomized Controlled Trial to Investigate Clinical and Biological Effects of Mindfulness-Based Cognitive Therapy in People with Parkinson’s Disease Background: People with Parkinson’s disease (PD) are highly sensitive to stress, which can exacerbate neuropsychiatric and motor symptoms. Mindfulness-based interventions (MBIs) have shown promise in reducing stress, depression, and anxiety in PD. Methods: The study aims to determine the effectiveness of Mindfulness-Based Cognitive Therapy (MBCT) in alleviating symptoms of anxiety and depression in PD patients. A total of 124 PD patients will undergo 8 weeks of MBCT or receive care as usual, with assessments at… ➡️➡️➡️

Ketamine vs Electroconvulsive Therapy for Treatment-Resistant Depression: A Secondary Analysis of a Randomized Clinical Trial ABSTRACT The ELEKT-D trial demonstrated that intravenous ketamine was noninferior to ECT for nonpsychotic TRD. This secondary analysis aimed to identify clinical features guiding the selection of ketamine vs ECT. MAIN OUTCOMES AND MEASURES The study found that outpatients with moderately severe or severe depression may consider ketamine over ECT for TRD, as they showed greater improvement with ketamine treatment. CONCLUSIONS AND RELEVANCE These findings suggest that intravenous ketamine may be a preferable option for certain patient groups with TRD, based on the observed greater… ➡️➡️➡️

Osteoporotic Precise Screening Using Chest Radiography and Artificial Neural Network: The OPSCAN Randomized Controlled Trial Radiology. 2024 Jun;311(3):e231937. doi: 10.1148/radiol.231937. Background: Diagnosing osteoporosis is difficult as it often shows no symptoms, so it’s crucial to screen high-risk populations. Purpose: This study assessed the effectiveness of using chest radiographs and an AI model to identify high-risk patients for osteoporosis and offer them fully reimbursed DXA examinations. Results: Out of the 40,658 participants, 12.1% were identified as high risk by the AI model, with 75.2% of those who underwent DXA examinations being diagnosed with new-onset osteoporosis. Conclusion: Providing DXA screening to high-risk… ➡️➡️➡️

Novel Autologous Dendritic Cell Therapy AVT001 for Type 1 Diabetes Key Findings AVT001, a dendritic cell therapy, showed potential efficacy and safety in a phase 1/2 trial for individuals with type 1 diabetes. Practical Solutions and Value AVT001 demonstrated no dose-limiting adverse events and suggested potential effectiveness in maintaining C-peptide levels. These findings indicate the need for further investigation in a larger trial. Importance of Clinical Trials Clinical trials are crucial for advancing safe and effective treatments, and it is essential to integrate their benefits into routine medical care. Streamlining Healthcare Operations Our AI-driven platform, DocSym, integrates ICD-11 standards, clinical… ➡️➡️➡️

Efficacy of Highly Bioavailable Oral Curcumin in Asymptomatic or Mild COVID-19 Patients: A Double-Blind, Randomized, Placebo-Controlled Trial Introduction Curcumin, known for its anti-inflammatory properties, has the potential to inhibit disease progression in COVID-19 patients. A highly absorbable form of curcumin, curcuRouge® (cR), was developed, and its effect on asymptomatic or mildly symptomatic COVID-19 patients was evaluated. Methods The study involved a 7-day oral intake of cR (360 mg twice daily) for patients within 5 days of COVID-19 diagnosis, with random assignment to a placebo or cR group in a double-blind manner. Results The cR group showed a lower rate of… ➡️➡️➡️

Feasibility of Robotic-Assisted Surgery in Advanced Rectal Cancer: VITRUVIANO Trial Key Findings The study assessed the outcomes of robotic surgery in patients with locally advanced rectal cancer. The results highlighted the feasibility of robotic-assisted surgery when strict surgeon experience criteria are met. Practical Solutions The study emphasized the importance of surgeon experience, with a criterion of more than 40 robotically assisted operations for rectal cancer, to ensure successful outcomes in advanced cases. Value This study provides valuable insights into the potential benefits of robotic-assisted surgery in locally advanced rectal cancer, offering a practical solution to improving patient outcomes and reducing… ➡️➡️➡️

Internet and Telephone Support for Discontinuing Long-Term Antidepressants: The REDUCE Cluster Randomized Trial ABSTRACT There is concern about long-term antidepressant treatment, and this trial aimed to assess the safety and effectiveness of adding internet and telephone support to a family practitioner review for considering discontinuing long-term antidepressant treatment. Participants were adults receiving antidepressants for more than 1 year for a first episode of depression or more than 2 years for recurrent depression, who were well enough to consider discontinuation and at low risk of relapse. The intervention involved internet and telephone self-management support, and the primary outcome was depression at… ➡️➡️➡️

Comparing Treatments for Macular Edema Secondary to Branch Retinal Vein Occlusion Background Macular edema (ME) is a common complication following branch retinal vein occlusion (BRVO) and is a major cause of visual impairment. This study aimed to compare the effectiveness and safety of three treatments for ME secondary to BRVO: intravitreal ranibizumab (IVR) monotherapy, dexamethasone implant (IDI) monotherapy, and a combination of IVR and IDI injections. Methods A total of 292 patients with unilateral ME secondary to BRVO were included in this study. They were randomly assigned to three groups and followed up for 12 months. Group 1 received IVR… ➡️➡️➡️

Effects of Aerobic Exercise on Neurocognitive Function in Postmenopausal Women with Breast Cancer Key Findings: Six months of moderate-intensity aerobic exercise improved processing speed, learning and memory, and working memory in postmenopausal women with breast cancer who were receiving endocrine therapy. Practical Solutions: Initiating aerobic exercise within two years of completing primary therapy (surgery +/- chemotherapy) can lead to improved neurocognitive function in this patient population. Value: This study provides valuable insights into the benefits of aerobic exercise on neurocognitive function in women with breast cancer. It highlights the potential for exercise interventions to enhance cognitive outcomes in this patient… ➡️➡️➡️

Phase II Study on Langerhans Cell Histiocytosis in Japan Key Points: – The study aims to improve outcomes for patients with Langerhans cell histiocytosis (LCH) by addressing recurrence and complications such as central diabetes insipidus and neurodegenerative diseases. – Dexamethasone is being tested to suppress LCH-associated inflammation, particularly in the central nervous system, while intrathecal chemotherapy is being evaluated to reduce CNS complications. – Zoledronate is being administered to patients with multifocal bone LCH based on promising results from a small case series. Practical Solutions and Value: – The study focuses on evaluating the effectiveness of dexamethasone and intrathecal chemotherapy… ➡️➡️➡️

Comparing the Effectiveness of Text-Message Reminders and Patient Navigation for Bowel Cancer Screening Introduction Participation in bowel cancer screening is lower in diverse and deprived regions. Text message reminders and patient navigation can help increase participation. This study aims to compare their effectiveness and cost-effectiveness. Methods and Analysis A three-arm randomised controlled trial will compare text message reminders, patient navigation, and usual care for increasing bowel cancer screening uptake in London. Participants will be individuals who have not returned a completed screening kit within 13 weeks. The primary endpoint will be participation in screening by week 24. Ethics and Dissemination… ➡️➡️➡️

Comparison of the Effect of Two Recruitment Manoeuvres to Conventional Ventilation on Lung Atelectasis in Paediatric Laparoscopic Surgery: A Prospective Randomised Controlled Trial Background Paediatric laparoscopic surgeries often result in pulmonary atelectasis. This study aimed to compare the use of recruitment manoeuvres or continuous positive airway pressure (CPAP) to conventional ventilation in preventing atelectasis. Objective The primary objective was to compare the degree of lung atelectasis diagnosed by lung ultrasound (LUS) using three different ventilation techniques in children undergoing laparoscopic surgeries. Design Randomised, prospective three-arm trial conducted at a single institute, tertiary care, teaching hospital. Patients Children up to the… ➡️➡️➡️

Association of Demographics, Lumbar Range of Motion, and Disability in Chronic Low Back: Baseline Data Analysis BMC Musculoskelet Disord. 2024 Jun 22;25(1):489. doi: 10.1186/s12891-024-07613-9. Background: Low back pain (LBP) poses a substantial burden on low and middle-income countries like Pakistan. This study aimed to explore the relationship between demographic factors, lumbar range of motion, and disability in patients with chronic low back pain. Methods: A baseline data analysis was conducted among 150 patients with chronic low back pain in a randomized controlled trial from March 2020 to January 2021. Demographics were recorded, and lumbar range of motion was measured using… ➡️➡️➡️

Comparison of Endoscopic versus Focused Parathyroidectomy in Surgical Management of Single-Gland Primary Hyperparathyroidism: A Randomized Clinical Trial Key Findings: The success rate for endoscopic parathyroidectomy was 95.3% compared to 77.1% for focused parathyroidectomy within the first five minutes. Postoperative calcium levels were significantly lower in the focused parathyroidectomy group. The focused parathyroidectomy method had a significantly shorter operation time. Patient satisfaction with cosmetic outcome was significantly higher in the endoscopic group. Conclusion: The endoscopic technique was found to be superior in managing single-gland primary hyperparathyroidism due to higher success rates, better postoperative calcium levels, shorter operation time, and improved cosmetic… ➡️➡️➡️

DISCOVER Trial: Automated Feedback for Internet-Based Depression Screening Background Many people with depression go undiagnosed and untreated despite effective treatments being available. We wanted to see if providing automated feedback after internet-based depression screening could help reach and provide evidence-based care for these individuals. Methods The DISCOVER trial was conducted in Germany and involved individuals aged 18 or older who screened positive for depression on an internet-based self-report scale. Participants were randomly assigned to receive no feedback, non-tailored feedback, or tailored feedback based on their screening results. The primary outcome was the change in depression severity 6 months after the… ➡️➡️➡️

Pilot Clinical Trial on Oral Hygiene Products Summary: A pilot study was conducted to evaluate oral hygiene products containing a prebiotic and paraprobiotic based on Lactobacillus plantarum. It aimed to assess patient satisfaction, recruitment rate, and rebalancing of the oral microbiota for future research. Findings: – All products were well-tolerated with no adverse events reported. – Group 4, using delicate mint toothpaste, mint mouthwash, and an antimicrobial toothbrush, showed the greatest reduction in gingival sensitivity. – All products induced a statistically significant decrease in plaque and a reduction in gingival sensitivity. – Oral microbiota stability was achieved with all tested… ➡️➡️➡️

Effect of Topical Brinzolamide on Visual Function in Infantile Nystagmus Syndrome Key Findings A randomized control trial evaluated the impact of topical brinzolamide on visual function and eye waveforms in infantile nystagmus syndrome (INS). Highlights: Significant improvement in INS waveform characteristics and visual acuity with brinzolamide No significant change in head position and stereopsis No reported side effects with 3 months of brinzolamide therapy Clinical Significance Brinzolamide shows promise in improving visual acuity and INS waveforms in idiopathic INS, but further evidence is needed to determine its clinical significance. Maximizing Clinical Trial Benefits in Everyday Practice Clinical trials play a… ➡️➡️➡️

EARLY Randomized Clinical Trial: 5:2 Intermittent Fasting Meal Replacement Diet and Glycemic Control for Adults With Diabetes Key Findings: An intermittent fasting plan of 2 nonconsecutive fasting days and 5 days of habitual intake per week combined with a meal replacement diet (5:2 MR) showed significant benefits for patients with early type 2 diabetes. Study Details: The study was conducted in 9 centers across China and included 509 eligible patients. 405 patients were randomly assigned to 3 groups for the 16-week treatment, with an 8-week follow-up. Results: Participants in the 5:2 MR group showed the greatest reduction in hemoglobin A1c… ➡️➡️➡️

Effect of Acupuncture on Tic Disorder: A Randomized Controlled Clinical Trial BMC Complement Med Ther. 2024 Jun 20;24(1):240. doi: 10.1186/s12906-024-04534-x. Background: Acupuncture is used to treat tic disorder, but there is a lack of clinical evidence supporting its efficacy. This study aims to investigate the potential mechanism of acupuncture in treating tic disorder by examining energy metabolism and infrared thermography in children with tic disorder. Methods: The study will recruit 90 children, dividing them into a non-intervention group (30 healthy children) and an intervention group (60 children with tic disorder). The intervention group will be further divided into a treatment… ➡️➡️➡️