Serplulimab Combined Therapy for Metastatic Pancreatic Adenocarcinoma Practical Solutions and Value Patients with metastatic pancreatic adenocarcinoma face a poor prognosis despite chemotherapy. This study aims to evaluate the effectiveness and safety of a combined treatment approach using PD-1 blockade, gemcitabine plus nab-paclitaxel chemotherapy, and stereotactic body radiotherapy (SBRT). This is a phase II clinical trial…
Distal Ventricular Pacing for Drug-Refractory Mid-Cavity Obstructive Hypertrophic Cardiomyopathy: A Randomized, Placebo-Controlled Trial of Personalized Pacing Key Findings Patients with severe symptoms from mid-cavity obstructive hypertrophic cardiomyopathy benefited from personalized pacing (PPoP) with reductions in obstruction and improved exercise performance. Practical Solutions Our AI-driven platform, DocSym, consolidates ICD-11 standards, clinical protocols, and research for easy…
Study Protocol: Qing-Xin-Jie-Yu Granules for Coronary Artery Disease Introduction Managing stable coronary artery disease (SCAD) is challenging despite available treatments. Intermediate coronary lesion (ICL) is a critical stage of SCAD, but current therapies have limitations. Qing-Xin-Jie-Yu Granules (QXJYG) may offer benefits as a complementary therapy due to its anti-platelet, anti-inflammatory, and lipid-lowering effects. Materials and…
The Effect of Itraconazole on the Pharmacokinetics of ACT-1004-1239 Key Findings: CYP3A4 is an important enzyme in drug metabolism and interactions. ACT-1004-1239 is a promising treatment for demyelinating diseases and is mainly metabolized by CYP3A4. This study looked at how the strong CYP3A4 inhibitor itraconazole affected the pharmacokinetics of ACT-1004-1239 in healthy male subjects. The…
No Improvement in Alcohol Screening and Brief Intervention Rates among Aboriginal Community Controlled Health Services Key Findings Results from a cluster randomised trial showed that providing training and support to Aboriginal Community Controlled Health Services (ACCHSs) did not lead to improvements in alcohol screening and brief intervention rates among wait-list control services. Practical Solutions Future…
Comparison of Case-Based and Lecture-Based Learning in Dental Fluorosis Diagnostic Ability with Visual Analog Scale Assessment Objective This study aimed to compare the impact of case-based learning (CBL) versus lecture-based learning (LBL) on dental students’ clinical decision-making regarding dental fluorosis (DF) severity using Visual Analog Scale (VAS) scoring. Methods Eighty first-year graduate dental students were…
Anti-inflammatory therapy with nebulized dornase alfa for severe COVID-19 pneumonia: a randomized unblinded trial Key Findings Dornase alfa, when administered through nebulization, effectively reduced systemic inflammation in severe COVID-19 pneumonia patients, as shown by a 33% reduction in C-reactive protein (CRP) levels compared to standard care. Practical Solutions The use of dornase alfa led to…
Equitable Care for Hypertension: Blood Pressure and Patient-Reported Outcomes of the RICH LIFE Cluster Randomized Trial Key Findings RICH LIFE study compared two interventions for hypertension control: standard of care plus (SCP) and collaborative care/stepped care (CC/SC). Both groups achieved significant blood pressure control rates at 12 months, with no significant differences between racial and…
Integration of Immuno-MESODEC Study into Epithelioid Malignant Pleural Mesothelioma Treatment Key Points Malignant pleural mesothelioma (MPM) is a very aggressive cancer with a poor prognosis. The Immuno-MESODEC study aims to integrate PD-L1 inhibitor atezolizumab and WT1/DC vaccination into the first-line treatment for epithelioid MPM patients. It is a multicenter, single-arm, phase I/II trial designed to…
Mindful Self-Compassion Smartphone Intervention for Worker Mental Health Practical Solutions and Value Highlights: Mental health issues among workers in Japan lead to significant losses for companies. Workers often face time constraints, limiting their access to psychological support. To address this, a smartphone app was developed to provide brief guided mindfulness meditation (MM) and self-compassion meditation…
The Efficacy of Early Office Hysteroscopy in Preventing Intrauterine Adhesions after Abortion: A Randomized Controlled Trial BMC Womens Health. 2024 Jul 13;24(1):400. doi: 10.1186/s12905-024-03247-0. Background: Intrauterine adhesions (IUA) are a common issue after intrauterine surgery and abortions, impacting fertility. This study aimed to assess if early office hysteroscopy can prevent IUA. Methods: The trial included…
Effects of Butyrate Supplementation on Ulcerative Colitis Patients Background The study aimed to investigate the effects of sodium-butyrate supplementation on the expression of circadian-clock genes, inflammation, sleep quality, and life quality in active ulcerative colitis (UC) patients. Methods 36 active UC patients were randomly divided to receive sodium-butyrate or placebo for 12 weeks. The expression…
Mediation Analysis of Obesity and Adiponectin Association with Postmenopausal Breast Cancer Risk Nutrients. 2024 Jun 30;16(13):2098 Summary: The study explored the relationship between obesity, adiponectin, and postmenopausal breast cancer risk. It investigated whether adiponectin or other biomarkers mediate the effect of body mass index (BMI) on postmenopausal breast cancer risk in a cohort study nested…
Development and Preliminary Evaluation of a Suicidal Risk Assessment Protocol Background Participants in research trials often report severe depression symptoms, including thoughts of self-harm and suicidal ideation. The lack of a standard protocol to respond to such disclosures may result in missed opportunities to support at-risk individuals. Methods Participants in the IBD-BOOST trial completed the…
A randomized controlled trial to assess if changing sleep timing can improve glucose metabolism in people with prediabetes and type 2 diabetes Practical solutions and value Social jetlag, a disruption in sleep timing, is linked to glucose metabolism issues, insulin resistance, and metabolic syndrome risks. This study aims to determine if a 3-week intervention involving…
Malaria Prevalence and Transmission in Zakpota Sub-district Baseline Characteristics for a Community Randomised Trial of a New Insecticide for Indoor Residual Spraying Background: Malaria transmission in Benin is perennial and varies across regions. Understanding local malaria prevalence, transmission levels, and vector characteristics is crucial for designing and evaluating new vector control interventions. This study in…
Dapagliflozin, Inflammation, and Left Ventricular Remodeling in Patients with Type 2 Diabetes and Left Ventricular Hypertrophy Background and Aim Sodium-glucose co-transporter 2 (SGLT2) inhibitors like dapagliflozin have shown benefits in heart failure (HF) by reversing remodelling, but the mechanisms behind these benefits are not fully understood. Inflammation is thought to contribute to HF, and there…
Affordable Web-Based Foot-Ankle Exercise Program for Diabetic Foot Care Key Findings: An affordable web-based foot-ankle exercise program, SOPeD, has proven effective in treating modifiable risk factors for ulcer prevention in individuals with diabetes-related peripheral neuropathy (DPN). The program effectively reduced foot pain, improved foot function, and demonstrated favorable cost-effectiveness. Practical Solutions and Value: The study…
Study Summary: Could TREM-1 be a Novel Marker in the Diagnosis of Fibromyalgia? Key Findings: Researchers investigated the potential role of TREM-1 in the context of fibromyalgia syndrome (FMS) and its association with disease activity. The study included 45 FMS patients and 46 healthy individuals as a control group. The findings revealed significantly elevated concentrations…
Enhancing treatment of lumbar disc herniation with Erxian decoction and auricular acupoint pressure: A randomized controlled trial Objective The study aimed to assess the clinical effectiveness of combining Erxian decoction with auricular acupoint pressure therapy in treating lumbar disc herniation (LDH). The goal was to provide evidence for integrating traditional Chinese medicine (TCM) rehabilitation techniques…