Placebo
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseImplementation and User Satisfaction of a Comprehensive Telemedicine Approach for SARS-CoV-2 Self-Sampling: Monocentric, Prospective, Interventional, Open-Label, Controlled, Two-Arm Feasibility Study
Implementation and User Satisfaction of a Telemedicine Approach for SARS-CoV-2 Self-Sampling Background Smartphones have opened up new ways to deliver healthcare through telemedicine. The COVID-19 pandemic increased the need for contactless health services, making SARS-CoV-2 testing essential. Objective This study aimed to evaluate a telemedicine approach for SARS-CoV-2 testing, focusing on its practicality, user satisfaction, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseIntraoral appliance treatment modulates inflammatory markers and oxidative damage in elderly with sleep apnea
Intraoral Appliance Treatment for Sleep Apnea in Elderly Patients Study Overview This study focuses on how an intraoral appliance (IOA) can help elderly patients with obstructive sleep apnea (OSA). OSA can lead to serious health issues due to inflammation and oxidative stress. The goal was to see if using an IOA could reduce these problems […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA New Approach to Retinal Oxygen Extraction Measurement Based on Laser Speckle Flowgraphy and Retinal Oximetry
A New Method for Measuring Retinal Oxygen Extraction Overview This study introduces a new method to measure how much oxygen is extracted by the retina, utilizing two commercial devices: laser speckle flowgraphy (LSFG) and retinal oximetry. Study Design The study involved healthy participants in a randomized, double-masked setup. Measurements were taken on two different days: […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Efficacy and safety of 4-hydroxy 2-methyl-N-(5-methyl-2-thiazolyl)-2H-1, 2-benzothiazin-3-carboxamide 1,1-dioxide, a fast-acting meloxicam formulation, on moderate-to-severe pain following abdominal surgery: A phase III randomized controlled trial
Efficacy and Safety of QP001 for Postoperative Pain Relief Study Overview QP001 is a new formulation of meloxicam designed to relieve moderate-to-severe pain after abdominal surgery. This study aimed to assess its effectiveness and safety. Trial Details This phase III trial involved 258 patients across 23 centers from October 30, 2022, to July 10, 2023. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe Ability of a Virtual Implantation Device to Evaluate Two Intraocular Lens Designs
The Ability of a Virtual Implantation Device to Evaluate Two Intraocular Lens Designs Study Overview This study aimed to assess a new device that uses virtual implantation to compare the visual performance of two types of intraocular lenses (IOLs). Methods In this clinical trial, researchers compared monofocal and low-add bifocal IOLs using a device called […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffects of Marrubium vulgare Extract on Hormonal Parameters and Clinical Findings in Polycystic Ovarian Syndrome: A Randomized, Placebo-Controlled, Triple-Blind Clinical Trial
Effects of Marrubium vulgare Extract on Hormonal Parameters and Clinical Findings in Polycystic Ovarian Syndrome Introduction Polycystic ovary syndrome (PCOS) is a common hormonal disorder in women of reproductive age. Marrubium vulgare has been traditionally used in Persian medicine to treat PCOS symptoms. This study investigates its effects on hormonal levels and symptoms of PCOS. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffectiveness of Working Memory Treatment on Naming Ability in Elderly People with Mild Cognitive Impairment Living in Bushehr City
Effectiveness of Working Memory Treatment on Naming Ability in Elderly People with Mild Cognitive Impairment Introduction Older adults with mild cognitive impairment often struggle to find words quickly, which can lead to frustration. This study examines how working memory treatment can help improve naming abilities in these individuals. Methods This study was a randomized clinical […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy of Jiangzhi Mai’an Granules in the treatment of stable angina pectoris with phlegm and blood stasis obstruction and carotid artery plaque: A prospective randomized study
Efficacy of Jiangzhi Mai’an Granules in Treating Stable Angina Pectoris Background Stable angina pectoris is a heart condition caused by artery blockages, leading to a reduced quality of life and increased risk of heart issues. Modern treatments can be difficult to manage. Traditional Chinese Medicine (TCM) sees this condition as caused by blockages of the […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseClinical Evaluation of Bioactive Injectable Resin Composite vs Conventional Nanohybrid Composite in Posterior Restorations: An 18-Month Randomized Controlled Clinical Trial
Clinical Evaluation of Bioactive Injectable Resin Composite vs Conventional Nanohybrid Composite in Posterior Restorations Study Overview The study compares the effectiveness of two types of dental materials for treating cavities in the back teeth over 18 months. Aim The goal is to see how well a bioactive injectable resin composite performs compared to a conventional […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCost-effectiveness of long-acting progestogens versus the combined oral contraceptives pill for preventing recurrence of endometriosis-related pain following surgery: an economic evaluation alongside the PRE-EMPT trial
Cost-Effectiveness of Long-Acting Progestogens vs. Combined Oral Contraceptives Study Overview This study evaluates the cost-effectiveness of long-acting progestogens (LAP), such as the levonorgestrel-releasing intrauterine system (LNG-IUS) and depot-medroxyprogesterone acetate (DMPA), compared to the combined oral contraceptive pill (COCP) for preventing endometriosis-related pain after surgery. Key Details Design: Economic evaluation alongside a randomized controlled trial. Setting: […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseElectroacupuncture promotes gastrointestinal functional recovery after radical colorectal cancer surgery: a protocol of multicenter randomized controlled trial (CORRECT trial)
Electroacupuncture for Recovery After Colorectal Cancer Surgery Study Overview This study, called the CORRECT trial, investigates how electroacupuncture (EA) can help patients recover from gastrointestinal issues after colorectal cancer surgery. Postoperative gastrointestinal dysfunction (POGD) is common and needs effective treatment options. Study Details The CORRECT trial will involve: 300 participants with colorectal cancer undergoing surgery. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseVirtual reality cognitive remediation tool for individuals with mild cognitive impairment: study protocol for a feasibility randomized clinical trial
Virtual Reality Tool for Cognitive Remediation in Older Adults Overview As the older population grows, there is a strong focus on finding new ways to support healthy aging. This study explores the use of virtual reality (VR) to help individuals with Mild Cognitive Impairment (MCI). Our goal is to see if this innovative approach can […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe Clinical Efficacy of Gegen Qinlian Decoction in Treating Type 2 Diabetes is Positively Correlated with the Dose of Coptidis rhizoma: Three Randomized, Doubleblind, Dose-Parallel Controlled Clinical Trials
The Clinical Efficacy of Gegen Qinlian Decoction in Treating Type 2 Diabetes Study Overview Recent studies show that the effectiveness of Gegen Qinlian Decoction (GQD) for type 2 diabetes (T2D) is linked to the dose of Coptidis Rhizoma. We conducted three clinical trials to explore this further. Study Details In our first study, we found […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Efficacy of Two-Week Treatment Using Bismuth, Omeprazole, Amoxicillin, and Ciprofloxacin on Eradication of Helicobacter Pylori compared to Three-Drug Treatment
Efficacy of Two-Week Treatment for Helicobacter Pylori Infection Introduction Helicobacter pylori is a common stomach infection that can lead to serious issues like gastritis and gastric ulcers. The World Health Organization has identified it as a major cause of gastric cancer. In Iran, about 54% of the population is infected. This study looked at a […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffect of Corticosteroid Injection and PRP in the Treatment of Trigger Finger: A Double-Blind Clinical Trial
Effect of Corticosteroid Injection and PRP in the Treatment of Trigger Finger Introduction Trigger finger is a condition where fingers catch or lock during movement, causing discomfort. It affects about 5-6% of people and can lead to serious functional issues if not treated quickly. This study looks at two non-surgical treatment options: corticosteroid injections and […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseConstipation Widespread and Comparison of Polyethylene Glycol with Lactulose Efficacy in Treatment of Patients with Constipation
Constipation in Children with Cerebral Palsy: A Study on Treatment Options Introduction Constipation is a common issue in children with cerebral palsy (CP), affecting 26% to 74% of them. This study looked at how often constipation occurs and how to manage it. We compared two treatments: polyethylene glycol (PEG) and lactulose, and also checked for […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Effect of Two Types of Time-Restricted Eating on Glycemic, Lipid Indices and Weight of Women with Polycystic Ovary Syndrome
Effect of Two Types of Time-Restricted Eating on Women with Polycystic Ovary Syndrome Introduction Polycystic ovary syndrome (PCOS) is a common hormone disorder affecting women of reproductive age. It increases the risk of various health issues like metabolic syndrome, heart disease, and type 2 diabetes. Time-restricted eating (TRE) is a form of intermittent fasting that […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePreVenTB trial: protocol for evaluation of efficacy and safety of two vaccines VPM1002 and Immuvac (Mw) in preventing tuberculosis (TB) in healthy household contacts of newly diagnosed sputum smear-positive pulmonary TB patients: phase III, randomised, double-blind, three-arm placebo-controlled trial
PreVenTB Trial Overview The PreVenTB trial is a major study testing the effectiveness and safety of two TB vaccines, VPM1002 and Immuvac (Mw), to prevent tuberculosis (TB) in healthy individuals living with newly diagnosed TB patients. This is a Phase III, randomized, double-blind, placebo-controlled trial taking place in India. Why This Study Matters TB is […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseStudy protocol of a randomised controlled trial of the effects of near-infrared spectroscopy neurofeedback training coupled with virtual reality technology in children with ADHD
Study Protocol Overview Background The increase in ADHD diagnoses in children shows a need for effective treatments. Neurofeedback training (NFT) has shown promise, but many studies are done in labs, which may not translate to real life. This study explores combining NFT with virtual reality (VR) to create a more realistic training experience that can […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseInvestigating the effect of the educational intervention based on the Health Belief Model on the knowledge and beliefs of Yemeni teachers in the use of breast cancer screening: a randomized controlled trial study
Investigating the Impact of Educational Interventions on Breast Cancer Screening Study Overview Breast cancer is the most common cancer among women. Teachers have an important role in encouraging healthy habits, such as breast cancer screening. This study looked at how an educational program based on the Health Belief Model (HBM) could improve knowledge and beliefs […] ➡️➡️➡️