Placebo
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffect of Implicit Learning Methods With the External Focus of Attention on Bowling Skills in Children With Autism Spectrum Disorder: A Randomized Control Trial Study
Study on Bowling Skills in Children with Autism Purpose The study aimed to compare two learning methods to improve bowling skills in children with autism spectrum disorder (ASD). Method Twenty children with ASD participated in the study. They were randomly divided into two groups. Before training, their bowling skills were assessed in two ways: Quantitative: […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAn eHealth Intervention to Improve Quality of Life, Socioemotional, and Health-Related Measures Among Older Adults With Multiple Chronic Conditions: Randomized Controlled Trial
An eHealth Intervention to Improve Quality of Life for Older Adults Background In the U.S., over 60% of adults aged 65 and older have multiple chronic health conditions. This leads to a lower quality of life, complex treatments that are less focused on patient needs, and higher healthcare costs. A previous study on ElderTree, an […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseInterleukin-1 Blockade With RPH-104 (Goflikicept) in Patients With ST-Segment Elevation Myocardial Infarction: Secondary End Points From an International, Double-Blind, Randomized, Placebo-Controlled, Phase 2a Study
Interleukin-1 Blockade With RPH-104 (Goflikicept) in STEMI Patients Study Overview This study focused on patients with ST segment elevation myocardial infarction (STEMI) and tested goflikicept, an interleukin-1 blocker. The goal was to see if it could reduce inflammation in the body. Key Findings Inflammation Reduction: Goflikicept significantly lowered inflammation levels after 14 and 28 days. […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffects of a Circuit Training Program on Myokine Levels in Insulin-Resistant Women: A Randomised Controlled Trial
Effects of a Circuit Training Program on Myokine Levels in Insulin-Resistant Women Study Overview This study examined how circuit training affects myokine levels in women with insulin resistance. Myokines are substances released by muscles that help regulate glucose metabolism. Methodology We conducted a controlled trial with 42 women, dividing them into two groups: Training Group: […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseImproving Lynch syndrome detection: a mixed-methods process evaluation of a hybrid type III effectiveness-implementation trial
Improving Lynch Syndrome Detection A Study Overview This study evaluated two methods to improve how healthcare providers refer patients for hereditary cancer testing, specifically for Lynch syndrome. The methods were based on either psychological theories or healthcare professionals’ intuition. Key Findings Interviews with 18 healthcare professionals revealed important themes: Complexity of Lynch Syndrome: Understanding the […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseTeach back educational strategy on knowledge about breast cancer among low health literate women
Teach-Back Educational Strategy for Breast Cancer Knowledge Background This study explores how a “teach-back” educational method helps women with low health literacy understand breast cancer better. Methods The research was conducted at the Farabi Comprehensive Health Services Center in Sanandaj, Iran, from December 2020 to October 2022. A total of 84 women, who struggled with […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseComparison of the impact of carotid endarterectomy and stenting on autonomic and baroreflex regulations: a one-year follow-up randomized study
Study Overview This study compares the effects of two treatments for carotid stenosis: carotid endarterectomy (CEA) and carotid artery stenting (CAS). Both treatments affect how the body regulates blood pressure and heart function. Key Findings 70 patients with carotid stenosis were randomly assigned to either CEA or CAS. After excluding some data, 33 patients underwent […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe Renewing Intimacy and SExuality Intervention for Female Cancer Survivors: A Feasibility Study
The Renewing Intimacy and Sexuality Intervention for Female Cancer Survivors: A Feasibility Study Purpose: This study looked into a three-session program aimed at helping women with breast and gynecologic cancer in Singapore improve their intimacy and sexual health. Method: Women from outpatient oncology clinics filled out questionnaires about their marital and sexual distress. Those who […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePsilocybin Therapy for Clinicians With Symptoms of Depression From Frontline Care During the COVID-19 Pandemic: A Randomized Clinical Trial
Psilocybin Therapy for Clinicians Experiencing Depression During COVID-19 Study Overview This clinical trial explored how psilocybin therapy could help US clinicians suffering from depression, burnout, and PTSD due to their frontline work during the COVID-19 pandemic. Key Findings Participants: 30 clinicians (physicians, APPs, and nurses) with moderate to severe depression symptoms were enrolled. Method: Participants […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePersonalized nutrition in type 2 diabetes remission: application of digital twin technology for predictive glycemic control
Personalized Nutrition for Type 2 Diabetes Remission Understanding Type 2 Diabetes Type 2 Diabetes (T2D) is a challenging condition caused by the body’s inability to use insulin effectively. Traditional diets often fail to consider how different people respond to food, which can hinder effective management of T2D. Our Goal This study introduces a Digital Twin […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA patient-centred care model for patients with complicated multimorbidity: Protocol for a pilot cluster randomised trial in general practice, municipalities, and hospitals
A Patient-Centred Care Model for Complicated Multimorbidity Study Overview This study focuses on improving care for patients with multiple health conditions who often experience disjointed treatment services. We have developed a structured care model called CIM2, tailored specifically for these patients. Key Elements of CIM2 CIM2 includes five main components: Training for Healthcare Professionals Comprehensive […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
The effect of breathing exercises on fatigue in tuberculosis patients: a randomized controlled trial
The Effect of Breathing Exercises on Fatigue in Tuberculosis Patients Study Overview This study explored how breathing exercises impact fatigue in tuberculosis patients through a randomized controlled trial. Study Design Patients were split into two groups: an intervention group (26 patients) and a control group (28 patients). The intervention group learned and practiced specific breathing […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseTriple-Combination Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel for Moderate-to-Severe Acne in Children and Adolescents
Triple-Combination Clindamycin Phosphate Gel for Acne in Children and Adolescents Overview This gel combines clindamycin phosphate, adapalene, and benzoyl peroxide to treat moderate to severe acne in patients aged 12 and older. It’s the only approved fixed-dose combination for acne treatment. Study Details Data from two phase 3 studies involving children and adolescents with acne […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Effective Motivational Interviewing-Based Counseling for Knee Osteoarthritis: A Randomized Controlled Trial
Effective Counseling for Knee Osteoarthritis: A Study Overview Objective This study aimed to see how motivational interviewing-based counseling affects pain, mental health, and self-care in people with knee osteoarthritis. Methods We conducted a randomized controlled trial with 60 participants (29 received counseling, 31 were in the control group). We collected data using: Personal Information Form […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Number of Retrieval Attempts and the Association of Intravenous Tirofiban with Symptomatic Intracranial Hemorrhage in Patients with Successful Endovascular Therapy: Results of the RESCUE BT Trial
Study Overview This study examines how intravenous tirofiban and the number of retrieval attempts relate to symptomatic intracranial hemorrhage (sICH) in patients undergoing endovascular therapy (EVT). Key Findings Participants: 866 patients were analyzed. Tirofiban Use: Patients receiving tirofiban had a higher risk of sICH (OR: 1.853). Retrieval Attempts: More than 2 retrieval attempts significantly increased […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Modifiable prognostic factors of high societal costs among people on sick leave due to musculoskeletal disorders: a replication study
Modifiable Prognostic Factors of High Societal Costs in Musculoskeletal Disorders Background Musculoskeletal disorders create significant challenges for society. This study focuses on understanding factors that can be changed to reduce high societal costs for individuals on sick leave due to these disorders. Methods We analyzed data from a clinical trial involving 509 participants in Norway. […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEvaluation of the clinical efficacy of modified LSC transplantation plus BCL implantation in the treatment of pterygium
Evaluation of Treatment for Pterygium Study Overview: This study investigates the benefits of modified limbal stem cell transplantation (Modified LSC) combined with bandage contact lens (BCL) implantation in treating pterygium. Objective: To assess how effective Modified LSC and BCL are in improving outcomes after pterygium surgery. Methods: A total of 479 patients with primary pterygium […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffect of cognitive-behavioral therapy-based physical play intervention on empathic ability of children with intellectual disabilities
Effect of Cognitive-Behavioral Therapy-Based Physical Play on Children’s Empathy Study Overview This study aimed to see if a sports game intervention based on cognitive-behavioral therapy could improve empathy in children with intellectual disabilities. Methodology A total of 31 children aged 7-8, diagnosed with intellectual developmental disorder, participated in the study. They were divided into two […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy and safety of minocycline in retinitis pigmentosa: a prospective, open-label, single-arm trial
Efficacy and Safety of Minocycline in Retinitis Pigmentosa Study Overview Retinitis pigmentosa (RP) leads to the gradual loss of vision due to the death of photoreceptor cells. This process is worsened by the activation of microglia, which are immune cells in the eye. Currently, there is no agreed-upon treatment for RP. Minocycline is known to […] ➡️➡️➡️
-
Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Ocrelizumab in Early-Stage Relapsing-Remitting Multiple Sclerosis: The Phase IIIb ENSEMBLE 4-Year, Single-Arm, Open-Label Trial
Ocrelizumab in Early-Stage Relapsing-Remitting Multiple Sclerosis Study Overview This study evaluated the effectiveness and safety of ocrelizumab as a first-line treatment for patients with early-stage relapsing-remitting multiple sclerosis (RRMS) over four years. Key Findings Patient Profile: 678 patients aged 18-55 with early-stage RRMS participated. No Evidence of Disease Activity: 66.4% of patients showed no evidence […] ➡️➡️➡️