An App-Based Intervention to Encourage Walking in Cancer Patients (APPROACH) Study Overview The APPROACH pilot study tested an app called NHS Active 10, designed to help cancer patients increase their brisk walking through simple support calls and printed materials. Study Goals This study aimed to: Evaluate how well the intervention was implemented. Understand how it…
Study on Suction Pressure and Bronchoalveolar Lavage Recovery Background Bronchoalveolar lavage (BAL) is an important diagnostic method. For effective diagnosis, a recovery rate of at least 30% is ideal. However, bronchial collapse due to negative suction pressure can hinder recovery. This study investigates how suction pressure levels during bronchial obstruction affect BAL recovery rates. Methods…
Treating Sleep Disturbances in Refugees and Asylum Seekers Study Overview This study focused on sleep issues common among traumatized refugees, specifically young Afghan men. It tested a group intervention called ‘Sleep Training adapted for Refugees’ (STARS), which is designed to be culturally relevant and based on proven treatments. Key Findings High Participation: Most participants attended…
SleepNow Study Overview The SleepNow study focused on men with metastatic prostate cancer (mPCa) who struggle with insomnia. It tested a new program that combines cognitive behavioral therapy for insomnia (CBT-I) with physical exercise. Study Details Participants: 12 men undergoing treatment for castration-resistant mPCa with insomnia. Method: Patients were divided into two groups: one received…
Early Fast-Track Care for HIV Patients in Haiti Introduction We studied the impact of starting fast-track care early for people diagnosed with HIV during a time of severe unrest in Port-au-Prince, Haiti. This approach is usually offered to patients already stable in their HIV treatment, but not to those newly diagnosed. Methods In our pilot…
Effects of Monitoring Dietary Biomarkers and Providing Vegetable Juice on Metabolic Syndrome in Overweight Adults Background Mongolian people often do not eat enough vegetables, leading to more cases of metabolic syndrome. Monitoring vegetable intake through dietary biomarkers, like skin carotenoid levels and the urinary sodium-to-potassium (Na/K) ratio, can help improve eating habits. Vegetable juices offer…
Ten Minutes of Core Stabilisation Exercise for Chronic Low Back Pain Relief Study Overview This study investigates how a simple 10-minute core stabilisation exercise can help reduce pain in patients with chronic low back pain (CLBP). It focuses on the immediate pain relief effects, known as exercise-induced hypoalgesia (EIH), and looks at factors that may…
Enhancing Foster Care Relationships through Attachment-Based Intervention Study Overview The Circle of Security Parenting program® (COS-P) aims to strengthen the relationships between foster carers and children. This program is especially important for children in out-of-home care, who often face mental health issues due to early challenges and instability. Study Design This study will assess the…
Impact of Cytogenetics on High-Risk Myelodysplastic Syndrome Treatment This study explores how the genetic traits of cancer cells affect the treatment and outcomes for patients with high-risk myelodysplastic syndrome (MDS), specifically those with a condition called deletion 5q. Patients received treatment with a drug called azacitidine, either alone or with another drug, lenalidomide. Key Findings:…
A Randomized Trial on Pharmacogenomics for Chronic Pain Treatment Study Overview This trial explored the impact of pharmacogenomic (PGx) results on patients with chronic pain in primary care, comparing it to standard treatment methods. It was a largely virtual study where participants were divided into two groups: one receiving PGx care and the other receiving…
Therapeutic Effects of Reduced Glutathione on Chronic Hepatitis B Objective This study aimed to assess how reduced glutathione, when combined with entecavir, affects liver function, fibrosis, and HBV-DNA clearance in patients with chronic hepatitis B. Methods We conducted a randomized controlled trial with 90 chronic hepatitis B patients. They were split into two groups: Control…
Improving Emotional Availability in Mother-Toddler Relationships Study Overview This study looked at how the Tuning in to Toddlers (TOTS) parenting program can help mothers and toddlers connect emotionally. The program was tested with parents of toddlers aged 18-36 months in Melbourne, Australia. Methodology Parents were divided into two groups: one group participated in the TOTS…
A New Laparoscopic Technique for Direct Inguinal Hernia Closure Study Overview This study aimed to create a new surgical technique for closing direct inguinal hernias and to assess the effectiveness and safety of a new type of suture used during surgery. Methods We conducted a study at Yudin State Clinical Hospital in Moscow from February…
Investigation of Cicaglocal for Wound Healing After Mohs Surgery Study Overview This study examines the effectiveness and safety of Cicaglocal, a supplement, in improving wound healing after Mohs surgery for skin cancer. Mohs surgery is a highly effective treatment, but managing wounds can be difficult, especially for older patients. Methodology The trial took place at…
Olaparib for IDH-Mutant Cholangiocarcinoma: Key Findings from a Clinical Trial Background Mutations in isocitrate dehydrogenase (IDH) lead to the buildup of 2-hydroxyglutarate (2-HG), which can promote tumor growth. These mutations also make tumors more susceptible to certain treatments, specifically poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors like olaparib. This study focuses on the use of olaparib…
Results of Cancer and Leukemia Group B 10102 (Alliance), a Phase 1/2 Study Background Acute lymphoblastic leukemia (ALL) in adults is a serious illness. Treatment can be challenging due to resistance and side effects. Most cases of B- and T-lineage ALL have CD52, a target for treatment. Alemtuzumab is a monoclonal antibody that targets CD52,…
Enhancing Clinical Practice in Resident Training Study Overview This study investigates how combining mentor-based learning (MBL) with resident-based learning (CMRL) can improve the training of medical residents. Background Mentor-based learning is common but has limitations, such as limited practice opportunities. This study introduces CMRL as a solution to enhance resident training effectiveness. Methodology Seventy-two residents…
A Comparative Study of Two Tracers in Breast Cancer Purpose This study explores the effectiveness of mitoxantrone hydrochloride injection (MHI) compared to technetium-99m (99mTc) for locating sentinel lymph nodes (SLNs) in breast cancer patients. Earlier research showed that MHI is safe and effective, and this study aims to identify any differences that were not previously…
Rucaparib vs. Chemotherapy for Relapsed Ovarian Cancer Study Overview The ARIEL4 trial compared rucaparib, a targeted therapy, to standard chemotherapy in women with relapsed ovarian cancer who have BRCA mutations. The main goal was to see if rucaparib could improve progression-free survival. Study Details This international study involved 64 hospitals across 12 countries. Women aged…
Cost-Effectiveness of Transcendental Meditation (TM) for PTSD Treatment Objective A recent study showed that Transcendental Meditation (TM) effectively helps veterans with Post-Traumatic Stress Disorder (PTSD) without focusing on trauma. This analysis looks into how cost-effective TM is for treating PTSD based on trial results. Methods From 2013 to 2017, 203 veterans with PTSD were divided…