miR-221-3p as a potential biomarker of chronic periodontitis and its regulatory effect on inflammatory response

miR-221-3p: A Potential Biomarker for Chronic Periodontitis

Overview

Researchers investigated the role of miR-221-3p in chronic periodontitis (CP) development and management. They aimed to uncover its diagnostic potential and therapeutic implications.

Key Findings

  • miR-221-3p levels were lower in CP patients compared to healthy individuals.
  • miR-221-3p demonstrated high diagnostic accuracy for CP, showing potential as a biological marker.
  • It was negatively correlated with periodontal indicators and inflammatory factors.
  • Overexpression of miR-221-3p reduced the production of inflammatory factors in lab-induced cells.

Clinical Relevance

The expression of miR-221-3p holds promise as a diagnostic bioindicator for chronic periodontitis. This research opens up new possibilities for CP diagnosis and treatment.

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