Influence of Oxygen Therapies on Patients with Sepsis
Study Overview
This study explored how different oxygen therapies affect patients with sepsis who are on mechanical ventilation. We compared two approaches: liberal oxygen therapy (target SpO2 ≥ 96%) and conservative oxygen therapy (target SpO2 88-92%).
Key Findings
- No significant difference in stroke volume and cardiac output between the two groups after 72 hours.
- Patients on conservative therapy were more likely to need vasopressors (84.9% vs. 66.0%) to maintain blood pressure.
- Older patients and those with higher SOFA scores were also more likely to require vasopressors.
Conclusions
Both oxygen therapy methods did not impact stroke volume or cardiac output. However, conservative oxygen therapy led to a higher need for vasopressors.
Clinical Trial Registration
This trial was approved by the Ethics Committee of Aswan University Hospital and registered on ClinicalTrials.gov.
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