Androgen Receptor Pathway Inhibitor Therapy for Advanced Prostate Cancer
Key Findings from a Clinical Trial
Importance: The LACOG0415 trial studied three treatment options for patients with advanced castration-sensitive prostate cancer (CSPC):
- Androgen deprivation therapy (ADT) plus abiraterone acetate and prednisone (AAP)
- Apalutamide (APA) alone
- APA combined with AAP
Objective: The study aimed to see how these treatments affect the health-related quality of life (HRQOL) of patients.
Study Details
The trial involved 128 patients who were randomly assigned to one of the three treatment groups from October 2017 to April 2019. The results were analyzed in 2022.
Treatment Methods:
Patients were divided equally into three groups, receiving:
- ADT plus AAP
- APA alone
- APA plus AAP
Main Outcomes:
HRQOL was measured using the FACT-P questionnaire, conducted at the start and every four weeks until week 25. Scores range from 0 to 156, with higher scores indicating better quality of life.
Results Summary:
All groups had similar baseline quality of life scores. By week 25, there were no significant changes in HRQOL across the treatment groups. The APA alone treatment showed better emotional well-being compared to ADT plus AAP.
Conclusions:
This analysis showed no meaningful differences in HRQOL between the treatment options. More extensive studies with longer follow-up are necessary for further insights.
Clinical Relevance:
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