Dr M. Trenton

Resistance Prehabilitation in Valvular Cardiac Surgery: A Clinical Trial Protocol Introduction Cardiovascular diseases (CVD) often require major surgery for treatment. Fast-track rehabilitation programs have shown promise in reducing postoperative complications and hospital stays. This study aims to assess whether adding resistance training (RT) to cardiac exercise-based prehabilitation can decrease intensive care unit (ICU) length of […] ➡️➡️➡️

Antibacterial Therapy for Acute Streptococcal Tonsillopharyngitis: Results of a Comparative Clinical Trial Background Acute tonsillopharyngitis is a common respiratory tract infection. Penicillin antibiotics like amoxicillin + clavulanic acid are often prescribed for bacterial causes. Dispersible forms of antibiotics have advantages over film-coated tablets, with better pharmacokinetic parameters, increasing effectiveness, safety, and patient compliance. Aim To […] ➡️➡️➡️

Phase 3b Study of Venetoclax and Azacitidine or Decitabine in Outpatient Setting for Acute Myeloid Leukemia Key Findings: Venetoclax combined with azacitidine or decitabine is approved for treating newly diagnosed acute myeloid leukemia (ND AML) in patients unable to undergo intensive chemotherapy. This study assessed the effectiveness and safety of this combination in a community-based […] ➡️➡️➡️

Summary of DIATEC Trial: Improving In-Hospital Diabetes Management Background Up to 20% of hospitalized patients have diabetes, leading to increased mortality, morbidity, and hospital stays. The DIATEC trial aims to improve in-hospital diabetes management strategies. Methods The trial is a two-armed, two-site, prospective randomised open-label blinded endpoint (PROBE) trial. Non-critically ill hospitalised patients with type […] ➡️➡️➡️

An mHealth Intervention for Gay and Bisexual Men’s Health in Romania: Clinical Trial Protocol Background The Comunică intervention aims to reduce HIV risk among gay and bisexual men in Romania, where stigma contributes to high HIV incidence. It involves live text-based counseling sessions using motivational interviewing and cognitive behavioral therapy skills. Objective This paper describes […] ➡️➡️➡️

Results from the LIVING Study: Predicting Postpartum Diabetes in Women with Gestational Diabetes Objective: To investigate the link between abnormal glucose values on antenatal oral glucose tolerance test (OGTT) and the risk of postpartum diabetes in South Asian women diagnosed with gestational diabetes (GDM). Methods: This analysis was conducted on participants from the Lifestyle Intervention […] ➡️➡️➡️

24-Hour Blood Pressure Variability Via Ambulatory Monitoring and Risk for Probable Dementia in the SPRINT Trial ABSTRACT Blood pressure variability is a risk factor for dementia, even when mean blood pressure levels are rigorously controlled. This study aimed to investigate the effect of ambulatory blood pressure variability on cognitive outcomes under intensive vs standard blood […] ➡️➡️➡️

Study Title: Demonstrating the effectiveness of intra-articular prolotherapy combined with peri-articular perineural injection in knee osteoarthritis: a randomized controlled trial Summary This study compared the effectiveness of different treatments for knee osteoarthritis (KOA). It involved 60 patients aged 48-80 with grade 2 or 3 KOA. Patients were divided into three groups and received different treatments. […] ➡️➡️➡️

Results of Haploidentical Hematopoietic Cell Transplantation for Adult Acute Myeloid Leukemia Study Overview A multicenter, randomized, phase 3 trial assessed the efficacy and safety of haplo-cord HCT in AML patients. A total of 268 eligible patients aged 18-60 years were randomly allocated to receive haplo-cord HCT or haplo-HCT. Main Findings The 3-year overall survival (OS) […] ➡️➡️➡️

Study Title: Trauma Exposure Among Individuals in Medication Treatment for Opioid Use Disorder Background Little is known about the lifetime trauma exposure of individuals in medication treatment for opioid use disorder (MOUD). A recent study examined the prevalence of lifetime trauma and differences based on gender, PTSD status, and chronic pain. Methods A cross-sectional study […] ➡️➡️➡️

Assessment of Safety in Diagnosing Interstitial Lung Disease Rationale and Objectives Bleeding is a common complication of transbronchial lung cryobiopsy (TBLC). This study aimed to determine if pre-placing a bronchial balloon during TBLC for diagnosing interstitial lung disease (ILD) is safer and more effective in preventing bleeding. Materials and Methods Patient with suspected ILD were […] ➡️➡️➡️

The Effect of Fermented Soy Beverage on Localized Prostate Cancer Patients Background Fermented soy products have shown to have inhibitory effects on prostate cancer. We evaluated the effect of a fermented soy beverage (Q-Can®) on men with localized prostate cancer prior to radical prostatectomy. Methods We conducted a placebo-controlled, double-blind randomized trial of Q-Can®. Patients […] ➡️➡️➡️

Semaglutide combined with empagliflozin vs. monotherapy for non-alcoholic fatty liver disease in type 2 diabetes: Study protocol for a randomized clinical trial Practical Solutions and Value Nonalcoholic fatty liver disease (NAFLD) is closely linked to type 2 diabetes mellitus (T2DM). This clinical trial aims to compare the effectiveness and safety of combining semaglutide and empagliflozin […] ➡️➡️➡️

Bleaching Efficacy of In-Office Dental Bleaching Objective This study aimed to compare the effectiveness and side effects of different in-office dental bleaching application protocols. Methods 165 participants underwent bleaching with a 35% hydrogen peroxide gel using three different protocols. Color change, tooth sensitivity, gingival irritation, self-perception, and oral health impact were evaluated. Results All protocols […] ➡️➡️➡️

Effects of NBI-1065845 on Drug Interactions in Healthy Adults Study Overview This study looked at the impact of NBI-1065845, a potential treatment for major depressive disorder, on the metabolism of midazolam and ethinyl estradiol-levonorgestrel in healthy adults. The results provide important insights into potential drug interactions. Key Findings After multiple doses of NBI-1065845, it was […] ➡️➡️➡️

Feasibility and Efficacy of Endoscopy with Blue Laser Imaging for Detecting and Diagnosing Cardia Polyps Key Findings from the Study: Detection rate of cardia polyps was higher with Blue Laser Imaging (BLI) compared to white-light imaging (WLI) Lower rate of overlooked lesions with BLI compared to WLI Diagnostic coincidence rate between magnifying BLI and histopathology […] ➡️➡️➡️

“`html A Randomized, Double-Blind, Placebo-Controlled Pilot Trial of the Acute Antisuicidal and Antidepressant Effects of Intranasal (R,S)-Ketamine in Severe Unipolar and Bipolar Depression With and Without Comorbid Alcohol Use Disorder ABSTRACT Objective: This study aimed to investigate the effects of intranasal (IN) racemic (R,S)-ketamine on antisuicidal and antidepressant outcomes in patients with unipolar and bipolar […] ➡️➡️➡️

“`html Efficacy and Safety of Choline Alfoscerate in Preventing Dementia in Elderly Patients Key Findings: Over a three-year period, a study involving 100 patients with mild cognitive impairment (aMCI) showed that annual therapy with choline alfoscerate (CA) had a significant preventive effect on the progression to clinically pronounced dementia. Patients receiving CA therapy experienced a […] ➡️➡️➡️

“`html ARTISAN RCT: Advice vs. Advice and Physiotherapy for Shoulder Dislocation Key Findings The study compared the effectiveness of advice alone versus advice with a physiotherapy program for first-time traumatic shoulder dislocation. The results showed little difference in the primary outcome or secondary outcomes between the two groups. However, the addition of physiotherapy was likely […] ➡️➡️➡️

“`html Reducing Time to Differentiated Service Delivery for Newly-Diagnosed People Living with HIV in Kigali, Rwanda: Pilot Trial Results Key Highlights: Examined feasibility, acceptability, and preliminary impact of entry into differentiated service delivery (DSD) at six months after ART initiation for newly-diagnosed PWH. Randomized controlled trial conducted in three health facilities in Rwanda. High patient-level […] ➡️➡️➡️