Dr M. Trenton
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseFree Interleukin 18 (IL-18F) Blood Levels Following Midline Laparotomy: A Prospective Randomized Study of Patients With Benign Disease and Patients With Cancer
Free Interleukin 18 (IL-18F) Blood Levels After Midline Laparotomy Study Overview This study examined the blood levels of free IL-18 (IL-18F) and other important markers in patients undergoing midline laparotomy (MLa). We compared patients with benign diseases and those with cancer to see how these levels relate to pain. Key Findings IL-18F levels decreased significantly […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseProtocol for evaluating the effects of integrating music with taekwondo training in children with autism spectrum disorder: A randomized controlled trial
Protocol for Evaluating Music Integration in Taekwondo for Children with Autism Overview This study aims to understand how adding music to Taekwondo training can help children with autism spectrum disorder (ASD) improve their motor skills and engagement in physical activities. Background Children with ASD often struggle with movement coordination. While exercise programs have shown positive […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe Role of Serum Free Fatty Acids in Endothelium-Dependent Microvascular Function
The Role of Serum Free Fatty Acids in Microvascular Function Background High levels of serum free fatty acids (FFA) are linked to insulin resistance and are common in metabolic syndrome. Insulin resistance often leads to poor blood vessel function. Objective We aimed to see if lowering FFA using two different medications—acipimox and salsalate—could improve blood […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseIt is Time to Address Fear of Cancer Recurrence in Family Caregivers: Feasibility and Acceptability of a Randomized Pilot Study of the Family Caregiver Version of the Fear of Recurrence Therapy (FC-FORT)
Addressing the Fear of Cancer Recurrence in Family Caregivers Study Overview This study focuses on the fear of cancer recurrence (FCR) experienced by family caregivers (FC) of cancer patients. FCR can lead to a lower quality of life and increased psychological distress. The goal was to test the Family Caregiver-Fear Of Recurrence Therapy (FC-FORT) to […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAutomatic Quality Control System and Adenoma Detection Rates During Routine Colonoscopy: A Randomized Clinical Trial
Automatic Quality Control System and Adenoma Detection Rates During Routine Colonoscopy Study Overview This clinical trial examined how an Automatic Quality Control System (AQCS) can improve adenoma detection rates during colonoscopy, which is crucial for reducing colorectal cancer risks. Key Findings Higher Detection Rates: The AQCS-assisted colonoscopy group had a significantly higher adenoma detection rate […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Intermittent Fetal Heart Monitoring Through Moyo Doppler Improves Nonreassuring Fetal Heart Rate Detection in Hospital of Ethiopia: A Randomized Controlled Trial
Intermittent Fetal Heart Monitoring with Moyo Doppler Improving Fetal Heart Rate Detection in Ethiopia Study Purpose: This study aimed to evaluate how effective intermittent fetal heart rate (FHR) monitoring with the Moyo Doppler is compared to the traditional fetoscope in Ethiopian hospitals in 2023. Background: The Moyo FHR monitor was introduced to help quickly identify […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSolving unknown primary cancer with earlier diagnosis — the SUPER-ED trial: study protocol for a stepped-wedge cluster randomised controlled trial to support earlier diagnosis for people presenting with malignancy of undefined primary origin
Addressing Unknown Primary Cancer with Early Diagnosis — The SUPER-ED Trial Background Patients with malignancy of undefined origin (MUO) face serious challenges, including poor outcomes and lengthy diagnostic processes. This often leads to patient distress and increased healthcare costs. Without a known primary diagnosis, timely treatment is delayed. Our goal is to enhance the diagnostic […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePrognostic Value of Coronary Angiography-Derived Index of Microcirculatory Resistance in Patients With Intermediate Coronary Stenosis
Prognostic Value of Angiography-Derived Index of Microcirculatory Resistance Study Overview This study investigates how the angiography-derived index of microcirculatory resistance (angio-IMR) relates to outcomes in patients with intermediate coronary stenosis. Key Findings The study involved 1,658 patients from the FLAVOUR trial. Patients were monitored for 24.8 months on average. Those with angio-IMR >25 had a […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseStatistical analysis plan for hemodynamic phenotype-based, capillary refill time-targeted resuscitation in early septic shock: the ANDROMEDA-SHOCK-2 randomized clinical trial
Statistical Analysis Plan for ANDROMEDA-SHOCK 2 Clinical Trial Background: The ANDROMEDA-SHOCK 2 trial is an international study comparing targeted resuscitation based on hemodynamic phenotype and capillary refill time to standard care in patients with early septic shock. The goal is to see if this targeted approach leads to lower complications and deaths. Objective: To outline […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseMinimally invasive compared to open surgery in patients with low-risk cervical cancer following simple hysterectomy: An exploratory analysis from the Gynegologic Cancer Intergroup/Canadian Cancer Trials Group CX.5/SHAPE trial
Minimally Invasive Surgery for Low-Risk Cervical Cancer Study Overview This study examines whether minimally invasive surgery (MIS) is safe for women with low-risk cervical cancer who have undergone simple hysterectomy. It builds on previous findings that showed worse outcomes for MIS in early-stage cervical cancer patients. Research Methods The analysis included 338 patients from the […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseExploring the Effect of Brief Preventive Videos on Mental Health Help-Seeking for Early Psychosis in a Young Community Sample
Exploring the Impact of Short Videos on Mental Health Help-Seeking in Young People Introduction Many young people do not seek help when experiencing early psychosis. This study looked at how short, informative videos could change their attitudes towards getting mental health care. Methods In this online study, 147 participants were divided into groups. They watched […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Exercise medicine as adjunct therapy during RADIation for CAncer of the prostaTE to improve treatment efficacy — protocol for the ERADICATE study: a phase II randomised controlled trial
Exercise Medicine to Enhance Cancer Treatment: The ERADICATE Study Overview The ERADICATE study explores how exercise can improve the effectiveness of radiation therapy for prostate cancer. Tumors often lack sufficient blood flow, leading to treatment resistance. This study aims to see if exercise can help by improving blood flow and reducing tumor hypoxia. Study Design […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCommunity benefits of mass distribution of three types of dual-active-ingredient long-lasting insecticidal nets against malaria prevalence in Tanzania: evidence from a 3-year cluster-randomized controlled trial
Community Benefits of Dual-Active-Ingredient Insecticidal Nets Against Malaria in Tanzania Background Long-lasting insecticidal nets (LLINs) were effective against malaria, but mosquitoes have become resistant to the main insecticides used. To address this, new dual-active ingredient LLINs (dual-AI LLINs) have been introduced. It’s essential to know how much these nets need to be used in a […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAddressing healthcare disparities and improving osteoporosis management in rural communities: a cluster randomized control trial
Addressing Healthcare Disparities in Rural Communities Overview Rural areas often struggle with healthcare access. A recent study tested ways to improve hospital visits and treatment rates for osteoporosis medication (AOM). It involved 567 patients divided into three groups. The findings revealed that those receiving special interventions had better hospital attendance and treatment rates than those […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Parsimonious versus extensive bleeding score: can we simplify risk stratification after percutaneous coronary intervention and reduce bleeding events by de-escalation of the antiplatelet strategy?
Understanding Bleeding Risk After Heart Procedures Study Overview This study compares two methods for assessing bleeding risk after a heart procedure called percutaneous coronary intervention (PCI). The goal is to simplify how doctors decide on antiplatelet therapy, which helps prevent blood clots. Key Methods The research analyzed data from the GLOBAL LEADERS trial, focusing on: […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseChinese herbal formula Tongxie Yaofang granules for diarrhoea-predominant irritable bowel syndrome: a randomised, double-blind, placebo-controlled, phase II trial
Chinese Herbal Formula for IBS-D: Study Overview Purpose of the Study This study aimed to evaluate how effective and safe Tongxie Yaofang (TXYF) granules are compared to a placebo for treating diarrhoea-predominant irritable bowel syndrome (IBS-D). Study Design The research was a phase II trial, which was randomised, double-blind, and placebo-controlled, ensuring unbiased results. Location […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffectiveness of Frequent Point-of-Care Molecular COVID-19 Surveillance in a Rural Workplace: Nonrandomized Controlled Clinical Trial Among Miners
Effectiveness of Frequent COVID-19 Surveillance in Rural Workplaces Background Many studies have looked at COVID-19 risks for healthcare workers, but fewer have focused on essential workers in other fields. There is limited guidance on how to keep workplaces safe outside of healthcare. The CDC recommends workplace surveillance, but few studies have explored how well this […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSpirituality-Based Intervention in Hypertension: EFfects on Blood PrEssure and EndotheliaL Function-FEEL Trial Results
Spirituality-Based Intervention in Hypertension: FEEL Trial Results Background Research shows that spirituality can improve health outcomes, but this area has not been extensively studied in clinical trials. Hypertension is a leading cause of heart-related health issues globally. Objectives This study aimed to see if a spirituality-based program could lower blood pressure (BP) and enhance blood […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseComparative study between efficacy of topical tofacitinib 2% ointment versus topical clobetasol propionate 0.05% ointment in hand eczema at a tertiary hospital in central India
Comparative Study on Hand Eczema Treatments Background Hand eczema is a common skin condition that affects many people and reduces their quality of life. Topical medications, like Clobetasol Propionate, are often used but may cause side effects with long-term use. This study will compare the effectiveness of two treatments: topical Tofacitinib 2% ointment and Clobetasol […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Evaluation of the Effect of Loperamide on the Cardiac Repolarization Interval Using Exposure-Response Analysis
Evaluation of Loperamide’s Effect on Heart Rhythm Study Overview This study explored how loperamide, a medication, affects the heart’s repolarization interval. It looked at both loperamide and its metabolite (M1) to see if they prolong the QT interval at normal and high doses. Study Design The analysis used data from healthy adults in a controlled […] ➡️➡️➡️