Dr M. Trenton
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAssessing the National Health, Education, and Air Quality Benefits of the United States Environmental Protection Agency’s School Bus Rebate Program: A Randomized Controlled Trial Design
Evaluating the Benefits of the EPA’s School Bus Rebate Program Introduction In the United States, around 25 million children take school buses to school. While school buses are generally safe, older buses can expose kids to harmful diesel exhaust, affecting their health and school attendance. To promote cleaner buses, the US Environmental Protection Agency (EPA) […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase[(18)F]FDG PET/CT performs better than CT in determining the bone biopsy site : randomized controlled clinical trial
Better Imaging for Bone Biopsies Study Overview A recent clinical trial found that [18F]FDG PET/CT is more effective than CT for locating biopsy sites in patients with suspected bone metastases. This study involved 273 patients treated between January 2020 and March 2021. Key Findings Higher Accuracy: [18F]FDG PET/CT showed an accuracy of 97.08% compared to […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy and safety of prostate radiotherapy in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design
Efficacy and Safety of Prostate Radiotherapy in Metastatic Castration-Sensitive Prostate Cancer Study Overview The PEACE-1 study investigated the effects of adding radiotherapy to standard treatments for men with newly diagnosed metastatic castration-sensitive prostate cancer. This study involved 77 hospitals across Europe and included 1173 male participants. Key Findings Improved Survival: Adding radiotherapy to standard care […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseOptimizing parenting and child outcomes following parent-child interaction therapy — toddler: a randomized controlled trial
Optimizing Parenting and Child Outcomes with Parent-Child Interaction Therapy-Toddler Overview Parent-Child Interaction Therapy-Toddler (PCIT-T) is a specialized therapy aimed at helping toddlers aged 12-24 months who exhibit challenging behaviors. Study Design This study used a randomized controlled trial to assess the effectiveness of PCIT-T on toddlers aged 14-24 months with disruptive behaviors. A total of […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAdditive effect of glenohumeral joint hydrodilatation applied in addition to suprascapular nerve blockage in patients with adhesive capsulitis
Additive Effect of Shoulder Treatments in Adhesive Capsulitis Study Overview This study explored the effectiveness of shoulder hydrodilatation (HD) combined with suprascapular nerve blockage (SSNB) for patients with adhesive capsulitis (AC). We focused on pain relief, shoulder movement, daily function, and hand strength. Methodology Forty-eight patients diagnosed with AC participated in this study. They were […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseDiagnostic Concordance Between Physiotherapist and Emergency Physicians for Patients With a Musculoskeletal Disorder in the Emergency Department
Diagnostic Agreement Between Physiotherapists and Emergency Physicians Study Overview Patients often visit the emergency department (ED) with musculoskeletal disorders. Some hospitals now allow physiotherapists to manage these conditions independently after initial assessment. Understanding how well physiotherapists and emergency physicians agree on diagnoses is important for implementing this care model effectively. Research Findings This study analyzed […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe application of flipped classroom to teaching diabetic retinopathy and glaucoma in ophthalmology undergraduate education: a randomized study
The Study on Flipped Classroom in Ophthalmology Education Overview This study explored how effective the flipped classroom method is for teaching diabetic retinopathy (DR) and glaucoma to medical students. Conducted at Peking Union Medical College, it involved 93 students divided into two groups. Key Findings Group A learned about diabetic retinopathy through a flipped classroom […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEvaluation and randomised controlled trial of home urinalysis testing in patients with SLE at elevated risk for developing lupus nephritis: a study protocol
Evaluation of Home Urinalysis Testing in Patients with SLE Study Overview This study focuses on lupus nephritis (LN), a common issue for patients with systemic lupus erythematosus (SLE). Up to 60% of adult SLE patients may develop LN, which can lead to serious kidney problems. Minority groups often face worse outcomes, making early detection crucial. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePostpartum maternal and infant haematological effects of second-trimester ferric carboxymaltose versus standard-of-care oral iron in Malawi: longitudinal follow-up of a randomised controlled trial
Postpartum Effects of Iron Treatment in Malawi Study Overview Anaemia is a significant issue for mothers and infants in their first year after childbirth, especially in sub-Saharan Africa. This study assessed whether a single dose of intravenous iron, ferric carboxymaltose, is more effective than standard oral iron for treating anaemia during the second trimester of […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA Comparative and Prospective Study of Corneal Consumption and Corneal Biomechanics After SMILE and FS-LASIK Performed on the Contralateral Eyes With High Myopic Astigmatism
A Study on Corneal Health After SMILE vs. FS-LASIK Published: Transl Vis Sci Technol. November 4, 2024; 13(11):29. DOI: 10.1167/tvst.13.11.29 Purpose of the Study This study compares how much corneal tissue is used and how the cornea’s mechanics change after two types of eye surgery: small incision lenticule extraction (SMILE) and femtosecond laser-assisted in situ […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Study protocol for a randomized controlled trial evaluating the effectiveness of a mother-child intervention model of neurogenic tremor as an add-on to treatment for emotional disorders in adolescents
Study Overview This study focuses on a new approach to help adolescents with emotional disorders by involving their mothers in a therapeutic program. Background Many adolescents face mental health issues, especially after the COVID-19 pandemic, leading to increased anxiety and depression. Traditional treatments like medication and therapy can be expensive and hard to access. Therefore, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePre-radiation Nivolumab plus ipilimumab in patients with newly diagnosed high-grade gliomas
Pre-radiation Nivolumab plus Ipilimumab for High-Grade Gliomas Study Overview This study explores the use of immune checkpoint inhibitors (ICIs) before radiation therapy in patients with newly diagnosed high-grade gliomas. We conducted a phase I trial with patients receiving: Nivolumab: 300 mg every 2 weeks Ipilimumab: 1 mg/kg every 6 weeks Treatment continued until disease progression […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe effects of a short exercise bout on executive functions in healthy older adults
The Impact of Short Exercise on Brain Function in Older Adults Study Overview This study investigates how a brief 20-minute session of moderate exercise affects cognitive abilities in healthy older adults. Regular physical activity is known to support brain health, but the effects of short exercise sessions are not fully understood. Key Findings Participants: 48 […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA randomized clinical trial evaluating Hydralazine’s efficacy in early-stage Alzheimer’s disease: The EHSAN Study
A Randomized Clinical Trial on Hydralazine for Early-Stage Alzheimer’s Disease: The EHSAN Study Overview Alzheimer’s Disease (AD) is a growing global issue with no cure available. Current treatments only help with symptoms. Hydralazine, a medication for high blood pressure, has shown promise in animal studies for protecting brain cells and improving their function. However, we […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
The clinical and microbiological efficacy of a zinc-citrate/hydroxyapatite/potassium-citrate containing toothpaste: a double-blind randomized controlled clinical trial
The Efficacy of a New Toothpaste: A Clinical Trial Overview Study Purpose This study aimed to test the effectiveness of two types of toothpaste, one with added ingredients like zinc-citrate (ZCT), hydroxyapatite (HAP), and potassium-citrate (KCit), and one with only fluoride. We wanted to see how well these toothpastes reduce bacteria, tooth sensitivity, plaque buildup, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseDigital Homework Support Program for Children and Adolescents With Attention-Deficit/Hyperactivity Disorder: Protocol for a Randomized Controlled Trial
Digital Homework Support Program for Children with ADHD Overview Attention-deficit/hyperactivity disorder (ADHD) affects about 4% to 5% of people. Homework time can be stressful for children with ADHD, leading to anxiety and family stress. Many kids with ADHD struggle more with homework than their peers, which can hurt their academic success. Traditional support methods can […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Approaches for improvement of ocular surface condition in primary open-angle glaucoma
Improving Eye Health in Glaucoma Patients Study Overview This study looks at how to improve eye surface health in patients with primary open-angle glaucoma (POAG) who also have dry eye syndrome (DES) and meibomian gland dysfunction (MGD). What We Did We included 48 patients with stage II POAG, who were treated with a specific eye […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAutism Transition to Adulthood Groups (ATAG): protocol for a feasibility RCT of a new peer-group intervention to promote successful transition to adulthood for autistic young people
Autism Transition to Adulthood Groups (ATAG) Overview of a New Study for Autistic Young Adults Study Purpose: This study aims to support autistic young people as they transition to adulthood. It focuses on improving their well-being through a new online peer-group program called ‘Understanding You, Discovering You’ (UYDY). Key Points of the Study: Target Group: […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Effect of a Stannous Fluoride Toothpaste Stabilized With Nitrate and Phosphates (SNaP) on Dentin Hypersensitivity: In Vitro Study and Randomized Controlled Trial
Effect of Stannous Fluoride Toothpaste on Dentin Hypersensitivity Background Dentin hypersensitivity is a common dental issue worldwide. This study tested a special toothpaste containing 0.454% stannous fluoride, along with nitrate and phosphates, to see if it could help reduce this sensitivity. Methods We treated human dentin samples with different toothpaste mixtures and checked how well […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCommunity Versus Facility-Based Services to Improve the Screening of Active Hepatitis C Virus Infection in Cambodia: The ANRS 12384 CAM-C Cluster Randomized Controlled Trial-Protocol for a Mixed Methods Study
Community Versus Facility-Based Services for Hepatitis C Screening in Cambodia Background: Hepatitis C is a major health issue in Cambodia, especially for those over 45 years old, with a prevalence of 5%. Improving access to screening and treatment is essential for eliminating hepatitis C. Objective: This study will compare the effectiveness of community-based screening versus […] ➡️➡️➡️