Dr M. Trenton
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseExploring therapeutic mechanisms of Chuan Huang Fang-II in the treatment of acute kidney injury on chronic kidney disease patients from the perspective of lipidomics
Exploring Therapeutic Mechanisms of Chuan Huang Fang-II in the Treatment of Acute Kidney Injury on Chronic Kidney Disease Patients Study Information Journal: Ren Fail. 2024 Dec;46(1):2356021 DOI: 10.1080/0886022X.2024.2356021 Date: Epub 2024 May 24 Objective This study evaluates the effectiveness and safety of CHF-II combined with RG for treating AKI on CKD (A on C) and […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEvaluating palliative care case conferences in primary care for patients with advanced non-malignant chronic conditions: a cluster-randomised controlled trial (KOPAL)
Evaluating Palliative Care Case Conferences in Primary Care for Patients with Advanced Non-Malignant Chronic Conditions: KOPAL Trial Background Patients with congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), and dementia often do not receive specialist palliative home care (SPHC) despite the complexity of their conditions. Collaboration between general practitioners (GPs) and SPHC teams is […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA comparison of port-site infiltration with bupivacaine alone vs. bupivacaine plus dexemedetomidine after diagnostic staging laparoscopy
A Comparison of Pain Relief Methods after Laparoscopy Objective To compare the effectiveness of using bupivacaine alone versus bupivacaine combined with dexmedetomidine for pain relief after laparoscopy procedures. Method A study conducted at a cancer hospital in Lahore, Pakistan, involving adult patients undergoing laparoscopy. Patients were divided into two groups, with Group A receiving bupivacaine […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseComparison of the effect of propolis and Gluma desensitizer on the management of dentin hypersensitivity: A randomized controlled trial
Comparison of Propolis and Gluma Desensitizer for Dentin Hypersensitivity Key Findings: Propolis and Gluma desensitizers were compared in a randomized controlled trial for managing dentin hypersensitivity. Immediate reduction in dentin hypersensitivity was observed with both agents. After one month, Gluma was found to be more effective than propolis. Practical Solutions and Value: Clinical trials are […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEarly diagnosis of melanoma: a randomized trial assessing the impact of the transmission of photographs taken with a smartphone from the general practitioner to the dermatologist on the time to dermatological consultation
Early Diagnosis of Melanoma: Impact of Smartphone Photo Transmission on Dermatological Consultation Time Background: Difficulty in obtaining timely dermatological consultation hinders early melanoma diagnosis. Optimizing patient care pathways is crucial to improve patient outcomes. Methods: A randomized controlled study involved 51 French GPs and 250 patients referred for suspected melanoma lesions. GPs were randomized to […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePreventive efficacy of 38% silver diamine fluoride and CPP-ACP fluoride varnish on molars affected by molar incisor hypomineralization in children: A randomized controlled trial
Preventive Efficacy of Silver Diamine Fluoride and CPP-ACP Fluoride Varnish on Molars Affected by Molar Incisor Hypomineralization in Children Overview This study compared the effectiveness of silver diamine fluoride (SDF) and Casein Phosphopeptide-Amorphous Calcium Phosphate fluoride Varnish (CPP-ACPFV) in preventing caries, enamel breakdown, and sensitivity in children with molar incisor hypomineralization (MIH). Key Findings The […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe use of medical imaging as a therapeutic patient education tool in radiotherapy : a feasibility study
Feasibility Study: Medical Imaging as Therapeutic Patient Education Tool in Radiotherapy Key Findings Cancer is a major public health challenge, and radiotherapy is a crucial treatment option. Medical imaging, previously used mainly by professionals, is now being explored for patient education. An experimental study at the University Hospital of Liège showed promising results. Patients who […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
The incidence and mortality of refeeding syndrome in older hospitalized patients, based on three different diagnostic criteria: A longitudinal study
Study on Refeeding Syndrome in Older Hospitalized Patients Background and Objectives Refeeding syndrome (RFS) lacks a global definition and diagnostic criteria. This study investigated the incidence of RFS and mortality rates in older hospitalized patients using three different diagnostic criteria: serum phosphate (traditional criterion), the Friedli consensus recommendations, and the ASPEN. Methods A total of […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseExploring concurrent validity of the CLN2 Clinical Rating Scale: Comparison to PedsQL using cerliponase alfa clinical trial data
Exploring concurrent validity of the CLN2 Clinical Rating Scale: Comparison to PedsQL using cerliponase alfa clinical trial data ABSTRACT The CLN2 Clinical Rating Scale assesses disease progression in CLN2 disease, a rare neurodegenerative disorder. To validate the scale, it was compared to the Pediatric Quality of Life Inventory (PedsQL) using clinical trial data on cerliponase […] ➡️➡️➡️
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A pilot randomised control study to investigate the effect of the South African Adolescence Group Sleep Intervention (SAASI) on adolescent sleep and PTSD
Study on South African Adolescence Group Sleep Intervention (SAASI) for PTSD Background Trauma exposure and post-traumatic stress disorder (PTSD) are significant issues among South African adolescents. Sleep disturbances are common in individuals dealing with PTSD. This study aimed to investigate the feasibility and initial effectiveness of the South African Adolescence Group Sleep Intervention on PTSD […] ➡️➡️➡️
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Digital therapeutics using virtual reality-based visual perceptual learning for visual field defects in stroke: A double-blind randomized trial
Digital Therapeutics for Visual Field Defects After Stroke: A Clinical Trial Introduction After a stroke, visual field defects (VFDs) can severely impact a person’s quality of life. A new approach called visual perceptual learning (VPL) using digital therapeutics has shown promise in restoring visual field sensitivity. This clinical trial aimed to assess the effectiveness and […] ➡️➡️➡️
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4-Aminopyridine treatment for nerve injury resulting from radical retro-pubic prostatectomy: a single-center double-blind, randomized, placebo-controlled study
4-Aminopyridine Treatment for Nerve Injury after Prostate Surgery Background Prostate cancer is a common and serious condition for men. Surgery to remove the prostate can lead to urinary incontinence and erectile dysfunction due to nerve injury. This study aims to evaluate the effectiveness of 4-aminopyridine (4AP) in improving these functions after surgery. Methods This study […] ➡️➡️➡️
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Hyperbaric oxygen therapy vs. pharmacological intervention in adults with fibromyalgia related to childhood sexual abuse: prospective, randomized clinical trial
Hyperbaric Oxygen Therapy vs. Medication for Fibromyalgia in Adults with Childhood Sexual Abuse: Clinical Trial Results Key Findings: Fibromyalgia syndrome (FMS) is a chronic pain condition often linked to childhood sexual abuse (CSA). This study compared hyperbaric oxygen therapy (HBOT) to standard medications for CSA-related FMS. Results showed that HBOT led to significant improvements in […] ➡️➡️➡️
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Clinical Value of Single-Projection Angiography-Derived FFR in Noninfarct-Related Artery
Clinical Value of Single-Projection Angiography-Derived FFR in Noninfarct-Related Artery Summary The study evaluated the diagnostic accuracy of the Murray law-based quantitative flow ratio (μFR) and the safety of deferring noninfarct-related artery (non-IRA) lesions with μFR >0.80 in acute myocardial infarction (AMI) settings. The results showed that deferred non-IRA with μFR >0.80 had a lower risk […] ➡️➡️➡️
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Comparison of the therapeutic effects of febuxostat combined with a low-purine diet and allopurinol combined with a low-purine diet on the improvement of gout patients
Comparison of Febuxostat and Allopurinol with Low-Purine Diet in Treating Gout Objective To compare the effectiveness of febuxostat with a low-purine diet versus allopurinol with a low-purine diet in treating gout. Methods A study with 98 gout patients compared the two treatments. Patients were evaluated based on joint function, serum uric acid levels, and inflammatory […] ➡️➡️➡️
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Rapid respiratory microbiological point-of-care-testing and antibiotic prescribing in primary care: Protocol for the RAPID-TEST randomised controlled trial
Protocol for the RAPID-TEST Randomised Controlled Trial Introduction In primary care, antibiotics are often prescribed for respiratory infections without clear benefit, leading to microbial resistance. Point-of-care-tests can provide rapid microbiological results, potentially improving antibiotic use and patient outcomes. However, their impact in primary care is not well understood. Methods This trial involves multiple primary care […] ➡️➡️➡️
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Clinical and cost-effectiveness of pessary self-management versus clinic-based care for pelvic organ prolapse in women: the TOPSY RCT with process evaluation
Clinical Trial Results: Pessary Self-Management vs. Clinic-Based Care for Pelvic Organ Prolapse Key Findings Self-management was acceptable and cost-effective, leading to fewer complications Quality of life for women with prolapse did not significantly improve or worsen compared with clinic-based care Situational factors impacted adherence and effectiveness in both groups Practical Solutions and Value The self-management […] ➡️➡️➡️
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Rationale and design of a double-blinded, randomized placebo-controlled trial of 40 Hz light neurostimulation therapy for depression (FELIX)
Rationale and design of a double-blinded, randomized placebo-controlled trial of 40 Hz light neurostimulation therapy for depression (FELIX) ABSTRACT BACKGROUND: Major depressive disorder (MDD) affects over 300 million people globally, and current treatments rely on trial-and-error. Reliable biomarkers are needed for more informed and personalized treatment solutions. Gamma-frequency brainwaves (30-80 Hz) are potential biomarkers linked […] ➡️➡️➡️
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Heat-sensitive moxibustion combined with tropisetron hydrochloride for chemotherapy-induced nausea and vomiting: a randomized controlled trial
Heat-sensitive moxibustion combined with tropisetron hydrochloride for chemotherapy-induced nausea and vomiting: a randomized controlled trial Objective To compare the effectiveness of heat-sensitive moxibustion combined with tropisetron hydrochloride versus tropisetron hydrochloride alone in treating chemotherapy-induced nausea and vomiting (CINV). Methods Sixty CINV patients were randomly divided into two groups. The control group received tropisetron hydrochloride, while […] ➡️➡️➡️
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Effectiveness of diagnosis and treatment based on movement system impairment in individuals with cervical pain: A randomized controlled trial
Effectiveness of Movement System Impairment Model in Treating Neck Pain: Clinical Trial Results Background Movement System Impairment (MSI) classification and treatment effectively diagnose and treat individuals with neck pain. Current guidelines lack movement-specific mechanical diagnosis for neck pain management. Purpose This study aimed to investigate the effectiveness of the movement system impairment model among neck […] ➡️➡️➡️
