Biomarkers
Study Overview
The study published in Alzheimers Dement. 2024 focuses on the effects of AGB101, a medication that aims to normalize brain activity in patients with mild cognitive impairment (MCI) related to Alzheimer’s disease (AD). The HOPE4MCI clinical trial lasted 78 weeks and evaluated the impact of AGB101 on patients who are ApoE-4 non-carriers.
Methods
Forty-four participants completed the trial. They underwent MRI scans to analyze brain structures and blood tests for plasma biomarkers. This helped measure changes associated with AD over the study period.
Key Findings
- Reduced Atrophy: AGB101 significantly decreased shrinkage in the left entorhinal cortex compared to placebo (p < 0.05).
- Correlation with Improvements: The reduction in brain atrophy was linked to better scores on cognitive assessments and lower levels of neurodegeneration biomarkers.
Conclusion
The results indicate that AGB101 may reduce brain atrophy and slow neurodegeneration in ApoE-4 non-carriers, potentially delaying the progression of Alzheimer’s disease.
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