Clinical trials
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe efficacy of combined physiotherapeutic scoliosis-specific exercises and manual therapy in adolescent idiopathic scoliosis
The Effectiveness of Combined Exercises and Therapy for Scoliosis in Teens Study Overview Adolescent idiopathic scoliosis (AIS) causes spinal curvature and trunk deformities in teens. This study looked at how well combined physiotherapeutic scoliosis-specific exercises (PSSE) and manual therapy (MT) work in treating AIS symptoms. Research Methodology Thirty-one teens with AIS, having a Cobb angle […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSerum Albumin Level at Intensive Care Unit Admission and Delirium Duration and Severity in Critically Ill Adults
Serum Albumin Level and Delirium in Critically Ill Adults Background Low serum albumin levels (hypoalbuminemia) are linked to a higher risk of delirium in hospitalized patients. However, how these levels affect the duration and severity of delirium is not well understood. Objective The goal of this study was to explore the connection between serum albumin […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffectiveness of King’s Theory of Goal Attainment in Blood Glucose Management for Newly Diagnosed Patients With Type 2 Diabetes: Randomized Controlled Trial
Effectiveness of King’s Theory of Goal Attainment in Blood Glucose Management Overview Diabetes is a major health issue worldwide, with millions affected. In China, around 140 million people have diabetes, and many struggle to follow their treatment plans. This study focuses on helping newly diagnosed type 2 diabetes patients manage their blood sugar levels effectively […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Diagnosis of Incident Cancer After Cryptogenic Stroke: An Exploratory Analysis of the ARCADIA Randomized Trial
Diagnosis of New Cancer After Cryptogenic Stroke Study Overview This study aimed to understand how often and when new cancers are diagnosed in patients who had a cryptogenic stroke. Study Methods We analyzed data from the ARCADIA trial, which included patients with cryptogenic stroke and atrial cardiopathy. Participants were monitored closely, and any serious health […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSpinal cord stimulation combined with exercise in patients diagnosed with persistent spinal pain syndrome. Study protocol for a randomized control trial
Spinal Cord Stimulation and Exercise for Persistent Spinal Pain Syndrome Study Overview This study investigates how spinal cord stimulation (SCS) combined with exercise can help patients with persistent spinal pain syndrome (PSPS-T2). The goal is to see if this combination can reduce pain, improve quality of life, and decrease disability. Study Design We are conducting […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseSafety and tolerability of tegoprubart in patients with amyotrophic lateral sclerosis: A Phase 2A clinical trial
Safety and Tolerability of Tegoprubart in ALS Patients: A Phase 2A Clinical Trial Study Overview This study focused on the safety and tolerability of tegoprubart, an anti-CD40L antibody, in patients with amyotrophic lateral sclerosis (ALS). The goal was to understand how it affects inflammation in the body. Key Findings Participants: 54 ALS patients received 6 […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAutologous platelet rich plasma injection can be effective in the management of osteoarthritis of the knee: impact on IL-1 β, TNF-α, hs-CRP
Effective Treatment for Knee Osteoarthritis with PRP Injections Study Overview: This study investigates the effectiveness of autologous platelet rich plasma (PRP) injections in treating knee osteoarthritis (KOA). It examines how these injections affect important biomarkers: interleukin-1 beta (IL-1β), tumor necrosis factor-alpha (TNF-α), and high-sensitivity C-reactive protein (hs-CRP). Methodology: 150 KOA patients from the Third Hospital […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePhase II study of uPAR-PET/CT for staging of primary breast cancer in comparison with ultrasound and fine needle biopsies
Phase II Study of uPAR-PET/CT in Breast Cancer Staging Overview Accurate staging of breast cancer is vital for effective treatment planning. Currently, no imaging method reliably detects lymph node metastases before surgery. Therefore, about 70% of patients rely on sentinel node procedures for determining their N status. Study Details In a clinical trial involving 49 […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCardiac remodelling in patients with atrial fibrillation and obstructive sleep apnoea
Cardiac Remodeling in Patients with Atrial Fibrillation and Obstructive Sleep Apnea Study Overview Obstructive sleep apnea (OSA) can affect heart structure, specifically the left atrium (LA) and left ventricle (LV), which are linked to atrial fibrillation (AF). This study explored whether using continuous positive airway pressure (CPAP) can improve heart structure in patients with OSA […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseOnce-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis
Once-Weekly Semaglutide in Persons with Obesity and Knee Osteoarthritis Study Overview This study investigated how a medication called semaglutide can help people with obesity and knee osteoarthritis. Losing weight can reduce knee pain, but the effects of semaglutide on knee osteoarthritis have not been thoroughly explored. Methodology The trial was conducted over 68 weeks and […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
A Virtual Breakthrough Series Collaborative for Missed Test Results: A Stepped-Wedge Cluster-Randomized Clinical Trial
A Virtual Breakthrough Series for Missed Test Results Importance Missed test results happen when healthcare providers do not follow up on test outcomes in a timely manner, causing delays in diagnosis and treatment. Objective This study aimed to assess how a quality improvement program, called the Virtual Breakthrough Series (VBTS), impacts the follow-up rates of […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Effect of multimodal opioid-sparing anesthesia on intestinal function and prognosis of elderly patients with hypertension after colorectal cancer surgery
Effect of Opioid-Sparing Anesthesia on Recovery in Elderly Patients After Colorectal Surgery Purpose The study focuses on how a specific type of anesthesia affects the recovery of elderly patients with hypertension who undergo surgery for colorectal cancer (CRC). It looks to improve recovery outcomes and reduce complications. Methods Researchers studied 80 elderly patients with hypertension […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseRegression and growth rates in androgen deprivation therapy for advanced castration-sensitive prostate cancer
Research Overview This study focuses on comparing cancer regression (d) and growth (g) rates in patients with advanced castration-sensitive prostate cancer (CSPC) undergoing androgen deprivation therapy (ADT). Purpose The goal is to understand how different ADT regimens affect tumor behavior, which can lead to more personalized treatment plans. This comparison may also help predict patient […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseExamining the effect of salbutamol use in ozone air pollution by people with exercise-induced bronchoconstriction
Study on Salbutamol and Ozone Air Pollution Effects Overview This study looked at how salbutamol affects people with exercise-induced bronchoconstriction (EIB) when exposed to ozone air pollution. Previous animal studies raised concerns about salbutamol’s safety in such conditions. Study Details We conducted a double-blind, randomized, placebo-controlled crossover study with 18 participants diagnosed with EIB. Each […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffects of HIV Self-Testing on Testing Promotion and Risk Behavior Reduction Among Transgender Women in China: Randomized Controlled Trial
Effects of HIV Self-Testing on Transgender Women in China Study Overview This study investigates how HIV self-testing (HIVST) impacts HIV testing behavior among transgender women in China. Key Objectives Evaluate changes in HIV testing behavior. Assess the frequency of condomless sex. Examine the number of sexual partners. Methodology Transgender women from two cities in China […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA Tailored Postpartum eHealth Physical Activity Intervention for Individuals at High Risk of Postpartum Depression-the POstpartum Wellness Study (POW): Protocol and Data Overview for a Randomized Controlled Trial
A Tailored Postpartum eHealth Physical Activity Intervention for Individuals at High Risk of Postpartum Depression-the POstpartum Wellness Study (POW) Overview This study focuses on postpartum depression (PPD), which can significantly affect both parents and their children. Traditional PPD prevention methods require a lot of healthcare resources. We need effective solutions that don’t add to this […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Sound Localization in Single-Sided Deafness; Outcomes of a Randomized Controlled Trial on the Comparison Between Cochlear Implantation, Bone Conduction Devices, and Contralateral Routing of Signals Hearing Aids
Study on Sound Localization in Single-Sided Deafness Overview This study compares different treatments for single-sided deafness (SSD) to see which one helps patients locate sounds better over time. It looks at cochlear implants (CI), bone conduction devices (BCD), contralateral routing of signals (CROS) hearing aids, and no treatment. Key Findings Participants: 120 SSD patients were […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Randomized Controlled Feasibility Trial of Late 8-Hour Time-Restricted Eating for Adolescents With Type 2 Diabetes
Randomized Controlled Feasibility Trial of Late 8-Hour Time-Restricted Eating for Adolescents With Type 2 Diabetes Background No previous studies have looked into how late time-restricted eating (lTRE) impacts blood sugar control or body composition in adolescents with type 2 diabetes (T2D). Objective The goal of this study was to see if lTRE is feasible, acceptable, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe effect of tranexamic acid on postpartum bleeding in women with moderate and severe anaemia (WOMAN-2): an international, randomised, double-blind, placebo-controlled trial
The Effect of Tranexamic Acid on Postpartum Bleeding in Women with Anaemia Study Overview This study, known as WOMAN-2, looked at whether tranexamic acid can help prevent postpartum bleeding in women with moderate or severe anaemia after childbirth. Key Details Type of Study: International, randomised, double-blind, placebo-controlled trial. Location: Conducted in 34 hospitals across Nigeria, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAssessment of the impact of combining butylphthalide and atorvastatin on neurological function, quality of life and vascular endothelial function in individuals diagnosed with acute cerebral infarction
Impact of Butylphthalide and Atorvastatin on Acute Cerebral Infarction Study Overview Acute cerebral infarction is a serious health issue, and finding effective treatments is essential. This study evaluated how combining Butylphthalide and Atorvastatin affects neurological function, quality of life, and blood vessel health in 124 patients with acute cerebral infarction. Key Findings Participants were divided […] ➡️➡️➡️