Clinical trials

“`html Recipient Biomarkers Predicting Metabolic Improvements After Fecal Microbiota Transplantation Key Highlights Fecal microbiota transplantation (FMT) combined with dietary fiber supplements improved glucose regulation in adults with severe obesity and metabolic syndrome. Recipients’ baseline fecal microbiota composition could predict improvements in insulin resistance after FMT. Responders to FMT therapy showed higher engraftment rates of donor-specific […] ➡️➡️➡️

“`html Study Title: Comprehensive Analysis of Neoadjuvant Camrelizumab and Chemotherapy for Locally Advanced Gastric Cancer Background The study aimed to evaluate the effectiveness of combining neoadjuvant camrelizumab with chemotherapy in treating locally advanced gastric cancer. This approach is being explored as a potential alternative to the current standard treatment. Methods The study involved a single-arm, […] ➡️➡️➡️

“`html Evaluation and Comparison of a New Desensitizing Paste Study Overview A clinical trial studied the effects of a new paste containing 8% L-Arginine and CaCO3 plus KNO3 on dentinal tubules occlusion and dental sensitivity. Methods 24 dentin surfaces were divided into two groups, one receiving the experimental paste and the other a placebo. Permeability […] ➡️➡️➡️

“`html Cost-effectiveness of Methenamine Hippurate vs. Antibiotic Prophylaxis for Recurrent Urinary Tract Infections Key Findings: Results from a multicentre trial showed that methenamine hippurate was on average less costly and more effective than antibiotic prophylaxis for managing recurrent urinary tract infections in women. Practical Solutions: Using methenamine hippurate could lead to cost savings and improved […] ➡️➡️➡️

“`html Effect of Vitamin D and Letrozole on Ovulation in Polycystic Ovary Syndrome Published: BMJ Open, April 29, 2024 Low vitamin D levels are common in women with polycystic ovary syndrome (PCOS). This study aims to evaluate the impact of vitamin D supplementation on ovulation rates with letrozole and other reproductive, endocrine, and metabolic outcomes […] ➡️➡️➡️

“`html Visual Performance of Optical Films Utilizing Spatio-Temporal Optical Phase Technology SIGNIFICANCE: Spatio-Temporal Optical Phase technology uses film pairs with optical elements on single-vision spectacle lenses. It has the potential to reduce myopia progression, but its visual performance is unclear. PURPOSE: This study aimed to evaluate the visual performance of film pairs containing optical elements […] ➡️➡️➡️

“`html Randomized Placebo-Controlled Clinical Trial of Dutasteride for Reducing Heavy Drinking in Men ABSTRACT Prior studies suggest that dutasteride, a medication used for benign prostatic hypertrophy, may help reduce heavy drinking in men by affecting certain brain chemicals. This study aimed to test the effectiveness and safety of dutasteride for this purpose. METHODS 142 men […] ➡️➡️➡️

“`html Study Title The influence of home versus clinic anal human papillomavirus sampling on high-resolution anoscopy uptake in the Prevent Anal Cancer Self-Swab Study Key Findings Anal cancer disproportionately affects sexual and gender minority individuals living with HIV. High-resolution anoscopy (HRA) is an in-clinic procedure to detect precancerous anal lesions and cancer. We examined whether […] ➡️➡️➡️

“`html Visual Performance of Optical Films Utilizing Spatio-Temporal Optical Phase Technology Published in Optom Vis Sci. 2024 Apr 1;101(4):195-203 Significance: Spatio-Temporal Optical Phase technology incorporates optical elements applied to standard single-vision spectacle lenses, offering a potential solution for slowing myopia progression. Purpose: This study aimed to evaluate the visual performance of film pairs containing optical […] ➡️➡️➡️

“`html Randomized Placebo-Controlled Clinical Trial of Dutasteride for Reducing Heavy Drinking in Men ABSTRACT Prior studies have shown that dutasteride, commonly used for benign prostatic hypertrophy, can reduce the production of certain neuroactive steroids associated with alcohol’s effects. This study aimed to evaluate the effectiveness and safety of dutasteride in reducing heavy drinking in men. […] ➡️➡️➡️

“`html The Prevent Anal Cancer Self-Swab Study Background Anal cancer disproportionately affects sexual and gender minority individuals living with HIV. High-resolution anoscopy (HRA) is an in-clinic procedure to detect precancerous anal lesions and cancer. We examined whether anal HPV sampling at home versus in a clinic impacts HRA uptake and assessed HRA acceptability. Methods Sexual […] ➡️➡️➡️

“`html Dynamic changes in the gut microbiota after bismuth quadruple therapy and high-dose dual therapy for Helicobacter pylori eradication ABSTRACT A study compared the impact of high-dose dual therapy (HDDT) and bismuth quadruple therapy (BQT) on the gut microbiota of patients with Helicobacter pylori infection. Patients provided fecal samples at baseline, Week 2, and Week […] ➡️➡️➡️

“`html Study Summary: Determining Optimal Bupivacaine Dose for Cesarean Section at High Altitude At moderately high altitudes, the need for local anesthesia during cesarean sections can be different due to altitude-related changes. This study aimed to find the right dose of bupivacaine for spinal anesthesia during cesarean sections at moderately high altitudes. Methods and Findings […] ➡️➡️➡️

“`html A Comparative Study of Clinical Outcomes in Locally Advanced Cervical Cancer Key Findings: The study compared the outcomes of two treatment approaches for locally advanced cervical cancer in women. It focused on the use of external beam radiation therapy (EBRT) and sequential High Dose Rate Intracavitary Brachytherapy (HDRICBT) with or without concurrent cisplatin administration […] ➡️➡️➡️

“`html The Impact of Tumor Hypoxia Modulation on sIL-2R Levels in Newly Diagnosed Diffuse Large B Cell Lymphoma (DLBCL) Patients Undergoing Chemotherapy: A Randomized Clinical Trial Objective This study aimed to investigate the effect of tumor hypoxia modulation using carbogen and nicotinamide on reducing soluble interleukin-2 receptor (sIL-2R) levels in newly diagnosed DLBCL patients with […] ➡️➡️➡️

“`html Safety and Efficacy of Umbilical Cord Tissue-Derived Mesenchymal Stem Cells in Treating Aging Frailty Key Findings: • Intravenous infusion of human umbilical cord-derived MSCs (HUC-MSCs) showed significant improvements in quality of life and physical performance in patients with aging frailty. • The treatment also led to a reduction in chronic inflammation, indicating its potential […] ➡️➡️➡️

“`html The Impact of Mindfulness-Based Stress Reduction on Acute Central Serous Chorioretinopathy Understanding Mindfulness-Based Stress Reduction Mindfulness-Based Stress Reduction (MBSR) is a form of meditation that combines mindfulness techniques with elements of cognitive-behavioral therapy. It aims to increase awareness of thoughts, emotions, and physical sensations without judgment or reaction, and has been shown to reduce […] ➡️➡️➡️

“`html Enhancing Diagnosis of Benign Lesions and Lung Cancer through Ensemble Text and Breath Analysis: A Retrospective Cohort Study The Study Lung cancer is a leading cause of cancer-related deaths worldwide, and early detection and accurate diagnosis are critical for improving survival rates. The study aimed to evaluate the effectiveness of using ensemble text and […] ➡️➡️➡️

“`html The Impact of Rimegepant Orally Disintegrating Tablet 75 mg on Acute Migraine Treatment in Adults from China Understanding Rimegepant Rimegepant is a new medication designed to provide fast relief for acute migraine attacks. It works by blocking a protein called CGRP, which is believed to play a key role in migraine attacks. The orally […] ➡️➡️➡️

“`html The Relationship Between Serum Resolvin D1, NLRP3, Cytokine Levels, and Adolescents with First-Episode Medication-Naïve Major Depressive Disorder What are Resolvins? Resolvins are natural compounds produced by the body that help reduce inflammation and promote tissue repair. The Role of Resolvin D1 in Depression Individuals with depression have been found to have lower levels of […] ➡️➡️➡️