Clinical trials

“`html Reproductive Outcomes in Young Women with Early-Stage Cervical Cancer Greater than 2 cm Undergoing Fertility-Sparing Treatment: A Systematic Review Summary Cervical cancer is a significant concern for young women. There is limited information about fertility-sparing treatment for cervical cancers larger than 2 cm. This review aimed to assess the reproductive outcomes of women with […] ➡️➡️➡️

“`html GNB1 Encephalopathy: Clinical Case Report and Literature Review Highlights Rare genetic disease caused by pathogenic variants in the GNB1 gene Only around 68 cases documented worldwide Main symptoms include mild developmental delay, cognitive impairment, dystonia, and nystagmus Diagnosis relies on genetic testing due to low specificity of symptoms No standardized treatment guidelines available Deep […] ➡️➡️➡️

“`html Transitioning to Personalized Care in Small-Cell Lung Cancer (SCLC) International Journal of Molecular Sciences, April 10, 2024 Summary: Lung cancer is a major concern worldwide, especially small-cell lung cancer (SCLC) which grows rapidly and is often diagnosed at an advanced stage. Recent clinical trials have shown that using immune checkpoint inhibitors in first-line chemotherapy […] ➡️➡️➡️

“`html Potential Benefits of Photon-Counting CT in Dental Imaging: A Narrative Review Background/Objectives: Photon-counting computed tomography (PCCT) is a new technology improving dental diagnosis and treatment planning. PCCT offers high resolution, improved soft-tissue contrast, and faster scanning times, essential for detailed dental diagnosis and treatment planning. It uses semiconductor detectors to produce sharper images and […] ➡️➡️➡️

“`html Fluorescence-Guided Laparoscopy for Staging of Gastric Cancer Practical Solutions and Value Hypericin, a fluorescent compound from plants, was tested to improve visualization of peritoneal metastasis (PM) in gastric cancer (GC) through laparoscopy. Study aimed to assess safety and feasibility of oral hypericin and the effectiveness of fluorescence-guided laparoscopy (FGL) for staging GC. Patients received […] ➡️➡️➡️

“`html Exploring the Link between Anticoagulation, Cognitive Impairment and Dementia in Atrial Fibrillation: A Systematic Review Background The review aims to understand how anticoagulants affect cognitive function and dementia in atrial fibrillation patients. Methods SCOPUS and PubMed were searched for English articles on OACs and cognitive impairment/dementia in AF patients. Non-original research and studies without […] ➡️➡️➡️

“`html Neutrophil Extracellular Traps and Respiratory Disease Practical Solutions and Value Neutrophil extracellular traps (NETs) play a crucial role in the initial immune response to infection but can also contribute to tissue damage due to their highly inflammatory nature. NETs are particularly relevant to lung diseases, and their presence has been demonstrated in conditions such […] ➡️➡️➡️

“`html Sonography as a Diagnostic Tool in Midurethral Sling Complications: A Narrative Review Key Points: Midurethral slings (MUS) are a common treatment for stress urinary incontinence (SUI) but can lead to postoperative complications. Sonography is a valuable tool for diagnosing complications from MUS procedures. This review examines the use of pelvic floor ultrasound in identifying […] ➡️➡️➡️

“`html Insights on Corneal Neurotization for Neurotrophic Keratopathy Practical Solutions and Value Neurotrophic keratopathy (NK) results from corneal denervation due to various trigeminal nerve dysfunctions. Modern corneal neurotization (CN) techniques aim to restore corneal sensitivity with less invasive options. Donor nerve selection and preparation are crucial for surgical success and often require multidisciplinary teams. Key […] ➡️➡️➡️

“`html Natural History of Retinal Sensitivity Loss in Diabetic Macular Ischemia Practical Solutions and Value This study observed how retinal sensitivity changes over one year in diabetic macular ischemia. Researchers recruited patients with stable-treated proliferative diabetic retinopathy and evidence of macular ischemia. They used microperimetry to assess retinal sensitivity at the beginning and end of […] ➡️➡️➡️

“`html Smoking and Lung Cancer Prognosis Recent research from the National Lung Screening Trial suggests that smoking behaviors at the time of lung cancer diagnosis can impact the stage of the cancer and the patient’s prognosis. Key Findings: Current smokers and those who smoke shortly after waking up tend to have more advanced-stage lung cancer. […] ➡️➡️➡️

“`html The Impact of Laparoscopic Myomectomy on Pregnancy Outcomes: A Systematic Review Study Objective: Investigate how laparoscopic myomectomy techniques affect pregnancy outcomes Focus on the correlation between suture type and uterine rupture incidence Examine how myoma localization and size influence fertility outcomes Data Sources: MDPI, PubMed, Web of Science, and Cochrane Library databases from 2008 […] ➡️➡️➡️

Targeted Nanoparticle-Based Diagnostic and Treatment Options for Pancreatic Cancer Cancers (Basel). 2024 Apr 20;16(8):1589. doi: 10.3390/cancers16081589. ABSTRACT Pancreatic cancer is difficult to diagnose and treat due to its aggressive nature and lack of early detection methods. The dense stroma around the tumor makes drug delivery challenging. Nanotechnology can provide solutions by creating new drug delivery […] ➡️➡️➡️

Latest Insights and Therapeutic Advances in Myelodysplastic Neoplasms Published in Cancers (Basel) on April 19, 2024 Myelodysplastic syndromes/neoplasms (MDSs) are a group of blood cancers that often affect older people. Changes in the genes of blood stem cells cause these diseases. New research on the genes of MDS has given us important information about how […] ➡️➡️➡️

Molecular Landscape and Therapeutic Strategies against Colorectal Cancer Molecular Landscape and Therapeutic Strategies against Colorectal Cancer Practical Solutions and Value Colorectal cancer (CRC) is the second leading cause of cancer deaths worldwide. Incidence of young-onset CRC (diagnosis before age 50) is increasing. Improved outcomes for CRC patients due to comprehensive molecular characterization of tumors and […] ➡️➡️➡️

“`html The Prognostic Value of Blood Test Indices in Cervical Cancer Patients Introduction: There is increasing interest in using routine blood tests like RDW and SII to predict survival in cancer patients receiving radiotherapy. This study aimed to assess the connection between pre-treatment RDW and SII levels and overall survival (OS) in patients with localized […] ➡️➡️➡️

“`html Study Title: Spatial profiling of ovarian carcinoma and tumor microenvironment evolution under neoadjuvant chemotherapy Purpose Investigate changes in immune tumor microenvironment (iTME) in ovarian cancer patients undergoing neoadjuvant chemotherapy (NACT) Correlate changes in immune cell subsets and coregulators with clinical outcomes Experimental Design Used multiplexed immune profiling and cell clustering analysis on paired ovarian […] ➡️➡️➡️

“`html Characterizing Technology Use and Preferences for Health Communication in South Asian Immigrants With Prediabetes or Diabetes: Cross-Sectional Descriptive Study JMIR Form Res. 2024 Apr 26;8:e52687 Background: Type 2 diabetes is a significant concern for South Asian groups. Lifestyle programs can help manage diabetes, but they need to be adapted for mobile health (mHealth). Objective: […] ➡️➡️➡️

“`html Protocol for a Prospective Noninterventional Study Importance of Early Detection of Preeclampsia in Pregnant Women Preeclampsia affects 2%-8% of pregnancies and can lead to high maternal and fetal mortality rates due to late identification. Misfolded proteins in urine samples may serve as a promising biomarker for predicting preeclampsia. Study Objectives and Methods Evaluate the […] ➡️➡️➡️

“`html Summary of Clinical Trial Results A study was conducted to evaluate the effectiveness of an educational program using technology-enhanced learning to teach neurology residents how to identify interictal epileptiform discharges (IEDs). Methods Junior neurology residents were randomly assigned to three groups: control, intervention 1, and intervention 2. The intervention involved video tutorials and rating […] ➡️➡️➡️