Effects of 12-Week Supplementation with Coffee Diterpene Cafestol in Healthy Subjects with Increased Waist Circumference: A Randomized, Placebo-Controlled Trial

Effects of 12-Week Supplementation with Coffee Diterpene Cafestol

Study Overview

This study looked at how cafestol, a compound found in coffee, affects healthy individuals with a larger waist size who are at risk of type 2 diabetes. Previous research shows coffee may help lower diabetes risk, but the effects of cafestol in humans needed more exploration.

Study Details

In this 12-week trial, 40 participants were randomly assigned to receive either cafestol (6 mg twice daily) or a placebo. Various tests, including insulin suppression tests and MRI scans, were conducted before and after the treatment period.

Key Findings

  • No change in insulin sensitivity or glucose tolerance: Cafestol did not improve these metabolic parameters.
  • Weight and fat reduction: Participants taking cafestol lost 2% of body weight, 5% of visceral fat volume, and saw a 15% decrease in gamma-glutamyl transferase levels compared to the placebo group.

Conclusions

Cafestol may help with weight and visceral fat reduction, but it did not improve insulin sensitivity or glucose tolerance in this study. It could still play a role in the link between coffee consumption and lower diabetes risk. Future studies should test higher doses and longer treatment times, especially for those with glucose metabolism issues.

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