Clinical trials

“`html Immunohistochemistry of Lung Cancer Biomarkers Practical Solutions and Value Immunohistochemical (IHC) staining is a cost-effective testing method for pulmonary biomarker testing. Specific antibody clones for certain genetic alterations, such as anaplastic lymphoma kinase, ROS-1, and neurotrophic tropmyosin receptor kinase, have provided robust results for targeted therapy. IHC can be used as a primary testing […] ➡️➡️➡️

“`html Diagnostic Positron Emission Tomography Imaging with Zirconium-89 Desferrioxamine B Squaramide: From Bench to Bedside Overview Molecular imaging with radiolabeled antibodies and Positron Emission Tomography (PET) can provide valuable information about specific biological interactions in individual patients. This approach has potential applications in identifying patients for targeted therapies, characterizing diseases, and monitoring treatment response. Using […] ➡️➡️➡️

“`html Practical Solutions and Value of Cancer Nutritional-Immunotherapy The study explores the use of carbonyl iron powder (CIP), an FDA-approved iron supplement, in anti-cancer treatment. This material is repurposed for its potential as a catalyst in the Fenton reaction, activator for dihydroartemisinin (DHA), and as a potent agent for NIR-II photothermal therapy (PTT) in an […] ➡️➡️➡️

“`html Summary of Clinical Trial: Bystander interaction with a novel multipurpose medical drone: A simulation trial Introduction Medical drones are new technology that can help in emergencies. Lay rescuers use these drones, but we don’t know much about how people interact with them and the best way to design them. Methods 24 simulations of adult […] ➡️➡️➡️

“`html Clinical Trial: Complications following surgical treatment of ankle fractures in the elderly: can they be avoided? Key Findings: Geriatric patients (65 years and older) have higher complication rates following surgical treatment of ankle fractures. Commonly used diagnostic and treatment methods do not account for the specific needs of elderly patients, increasing the risk of […] ➡️➡️➡️

“`html Practical Solutions and Value in Clinical Trial Case Study: Multiple Brain Tuberculomas in the Subarachnoid Cisterns Recognition of Radiological Characteristics Development of Paradoxical Response during Antituberculosis Treatment Brain tuberculoma within subarachnoid cisterns is rare in Japan, making diagnosis challenging. A 70-year-old woman with suspected tuberculous meningitis (TBM) was enrolled in a clinical trial for […] ➡️➡️➡️

“`html COVID-19 Surveillance Using Consumer Wearable Devices Summary Consumer wearable devices like wristbands and smartwatches can help monitor COVID-19 patients. A study was conducted to see how well wearable devices can track COVID-19 patients of different severity. Physiological data and electronic questionnaires were collected from the devices worn by patients until 14 days after they […] ➡️➡️➡️

“`html Automated Osteoporosis Classification and T-Score Prediction Practical Solutions and Value Using a deep learning algorithm, this study aims to classify osteoporosis and predict T-scores on the hip region through simple hip radiographs. A dataset of 3460 hip images from 1730 patients was used to train and test the proposed model, which showed a better […] ➡️➡️➡️

“`html Effects of Korean Versus Western Diets on Reproductive Function in Young Korean Men: A 12-Week Randomized Parallel Clinical Trial ABSTRACT Unhealthy diets may lead to a decline in sperm quality. This study compared the effects of Korean and Western diets on reproductive function in young Korean men. METHODS Participants were given either the Korean […] ➡️➡️➡️

Real-World Effectiveness of Antibiotic Strategies for Urinary Tract Infection Real-World Effectiveness of Antibiotic Strategies for Urinary Tract Infection Study Overview A study was conducted to compare the effectiveness of different antibiotic treatments for gram-negative bloodstream infection from a complicated urinary tract infection source. Methods Multicenter observational cohort study Comparison of intravenous and oral antibiotic regimens […] ➡️➡️➡️

Asynchronous Video Directly Observed Therapy for Tuberculosis Treatment Practical Solutions and Value Medication adherence for tuberculosis treatment can be monitored effectively and cost-efficiently using self-recorded videos (video directly observed therapy [VDOT]) instead of in-person observation. A randomized controlled trial compared VDOT and clinic-based monitoring for patients with latent tuberculosis infection (LTBI) undergoing a 3-month treatment. […] ➡️➡️➡️

“`html Identifying Time-Resolved Features of Nocturnal Sleep Characteristics of Narcolepsy Using Machine Learning Summary Narcolepsy type 1 is difficult to diagnose due to similar symptoms with other disorders. A machine learning framework was developed to differentiate narcolepsy type 1 nighttime sleep features from other disorders. Polysomnography data from 350 individuals was analyzed to identify distinct […] ➡️➡️➡️

“`html Prophylactic-dose direct oral anticoagulants for non-hospitalised people with COVID-19: A meta-analysis of randomised controlled trials Summary Investigated the impact of prophylactic-dose direct oral anticoagulants (DOACs) in non-hospitalised COVID-19 patients. Compared DOACs with placebo or no treatment in six randomised controlled trials involving 4307 patients. Found that prophylactic-dose DOAC therapy significantly decreased risks of all-cause […] ➡️➡️➡️

“`html Study Title The toxicity of chlorine dioxide to clownfish and its bactericidal capability to pathogenic strains of vibrio spp Abstract Global transportation of ornamental fish can stress fish and cause mortality Clownfish are commonly traded and susceptible to pathogenic strains of vibrio Prophylactic treatment of water or fish is recommended In this study, chlorine […] ➡️➡️➡️

“`html Summary: The Role of Non-Oropharyngeal Biopsies in Head and Neck Squamous Cell Carcinoma of Unknown Primary: A Systematic Review Introduction – This review looks at the use of biopsies in non-oropharyngeal areas for patients with head and neck squamous cell carcinoma of unknown primary (HNSCCUP). Methods – The review followed the Preferred Reporting Items […] ➡️➡️➡️

“`html The revision and factor analytic evaluation of the German version of the depression literacy scale (D-Lit-R German) Abstract Depression is a common mental health disorder and the second leading cause of disability worldwide. Low depression literacy can hinder adequate therapy for depression. The German Depression Literacy Scale (D-Lit) has been revised and evaluated in […] ➡️➡️➡️

“`html Study Summary: Comparing Traditional and Digital Crown Extension Guides for Anterior Teeth Restoration Objective: Compare clinical outcomes of traditional and digital crown extension guides for aesthetic restoration of anterior teeth Analyze differences in results of various digital crown extension guides Methods: 62 patients needing anterior teeth restoration Randomly divided into three groups: control, experimental […] ➡️➡️➡️

“`html Perioperative Right Ventricular Dysfunction: Understanding the Risks and Implications In this edition of the journal, the Perioperative Quality Initiative (POQI) presents three manuscripts focusing on the physiology, assessment, and management of right ventricular dysfunction (RVD) in the perioperative setting. Risk Factors for Perioperative RVD Pre-existing RVD Fluid overload Myocardial ischemia Pulmonary embolism Lung injury […] ➡️➡️➡️

“`html Study Summary: Movement System Impairment-Based Classification for Knee Pain Background: Knee pain is a common issue, and movement impairments can contribute to it. This study aims to compare the effectiveness of a movement system impairment-based treatment with routine physiotherapy for individuals with tibiofemoral rotation syndrome. Methods: 22 individuals with knee pain were included in […] ➡️➡️➡️

“`html Summary of Research on Behavioral Interventions for Autism Background: Behavioral interventions for autism, specifically Naturalistic Developmental Behavior Interventions (NDBIs), have gained popularity as effective treatments. However, there is a lack of research on which NDBI method is most effective for parents and children with autism spectrum disorders. Methods: 32 randomized controlled trial studies were […] ➡️➡️➡️