Practical Solutions and Value of On-Treatment Biopsies in Predicting Response to Neoadjuvant Chemotherapy for Breast Cancer
Key Highlights:
- On-treatment biopsies provide early insight into treatment response for invasive breast cancer.
- Patients with complete response to chemotherapy may require less aggressive treatments.
- Biopsies can help adapt therapies and improve outcomes.
- Examining factors like tumor quantity, TILs, and Ki-67 levels can predict pathologic complete response and disease-free survival.
Value Proposition:
- Identifying patients unlikely to achieve complete response post-therapy allows for treatment adjustments.
- Especially beneficial for triple-negative and HER2+ breast cancer cases.
- Insights into therapy resistance mechanisms can guide further treatment strategies.
- Research should focus on improving the accuracy of on-treatment biopsy procedures.
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