Clinical trials
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Radial endobronchial ultrasound – guided bronchoscopy for the diagnosis of peripheral pulmonary lesions: A systematic review and meta-analysis of prospective trials
“`html Radial Endobronchial Ultrasound (r-EBUS) for Diagnosing Peripheral Pulmonary Lesions (PPLs) Key Findings: The diagnostic yield of r-EBUS for PPLs is approximately 73.4%. Factors influencing diagnostic yield include location and size of the lesion, type and appearance on CT, presence of certain signs, and use of rapid on-site evaluation (ROSE). Overall complications, pneumothorax, and bleeding […] ➡️➡️➡️
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Clinical, pathologic and molecular findings in 2 Rottweiler littermates with appendicular osteosarcoma
“`html Appendicular Osteosarcoma in Dogs: Clinical Trial Results Summary A clinical trial studied two Rottweiler dogs with appendicular osteosarcoma. Despite receiving similar treatment, they had different outcomes. Various techniques were used to analyze their tumors and identify factors influencing their response to treatment. Comparison with a companion cohort of Rottweiler dogs provided new insights into […] ➡️➡️➡️
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Efficacy and safety of Shen Gui capsules for chronic heart failure: a systematic review and meta-analysis
“`html Summary of Clinical Trial on Shen Gui Capsules for Chronic Heart Failure Study Overview Assessed the effectiveness and safety of Shen Gui capsules (SGCP) as an adjuvant treatment for chronic heart failure (CHF). Reviewed nine randomized controlled trials (RCTs) involving 888 CHF patients. Key Findings Positive Effects: SGCP combined with conventional therapy showed significant […] ➡️➡️➡️
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Advancing Healthcare Equity in Nephrology: Addressing Racial and Ethnic Disparities in Research Trials and Treatment Strategies
“`html Addressing Gender and Racial Inequalities in Nephrology Key Points: Women from underrepresented racial groups face challenges in kidney disease research due to lack of representation. Systemic biases in healthcare hinder access and quality of care for kidney diseases. Practical Solutions: Recalibrate risk stratification models to include gender- and race-specific factors. Transform healthcare policies to […] ➡️➡️➡️
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Molecular insights into clinical trials for immune checkpoint inhibitors in colorectal cancer: Unravelling challenges and future directions
“`html Colorectal Cancer and Immunotherapy Colorectal cancer (CRC) is a complex disease with low survival rates, especially in advanced stages. Recent advancements in cancer treatment, particularly with immunotherapies targeting immune checkpoints, have shown promise in clinical trials. Practical Solutions and Value Immunotherapies like PD-1 inhibitors have been approved for treating certain types of advanced CRC. […] ➡️➡️➡️
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Development of an Infantile GM2 Clinical Rating Scale: Remote Assessment of Clinically Meaningful Health-Related Function
“`html Practical Solution for GM2 Gangliosidoses Challenges Addressed: Rare lysosomal storage disorder causing central nervous system damage Lack of feasible clinical outcome assessments for GM2 Value Offered: Potential for improved outcomes with early diagnosis and pharmacotherapies Development of Infantile GM2 Clinical Rating Scale for health-related function assessment “` ➡️➡️➡️
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Six versus four or five cycles of first-line etoposide and platinum-based chemotherapy combined with thoracic radiotherapy in patients with limited-stage small-cell lung cancer: A propensity score-matched analysis of a prospective randomized trial
“`html Study Summary: Comparing Chemotherapy Cycles for Small-Cell Lung Cancer Researchers compared the outcomes of patients with limited-stage small-cell lung cancer (LS-SCLC) who received either 6 cycles or 4-5 cycles of chemotherapy combined with thoracic radiotherapy (TRT). Key Findings: Patients who received 6 cycles of chemotherapy showed significant improvement in overall survival (OS) and progression-free […] ➡️➡️➡️
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Diode laser as an adjunctive treatment for periodontitis: Arandomized controlled trial
“`html Study Summary: Subgingival Instrumentation with Diode Laser in Periodontitis Treatment Objective: The study aimed to compare the effectiveness of subgingival instrumentation (SI) with and without diode laser (DL) in treating periodontitis. Methods: Participants were randomly assigned to receive either SI with DL or SI alone. Clinical parameters and patient-reported outcomes were measured at baseline, […] ➡️➡️➡️
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Efficacy of mobile phone intervention to increase male partner antenatal care attendance for HIV testing in Moshi municipal, Tanzania: a randomized controlled trial
“`html Study Summary: Increasing Male Partner Involvement in Antenatal Care Background HIV partner counselling and testing in antenatal care (ANC) is important, but male involvement in ANC is low in many places like Tanzania. This study aimed to see if using mobile phone interventions could increase male partner attendance for HIV testing in Moshi municipal, […] ➡️➡️➡️
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Comparison of novel PSMA-targeting [177Lu]Lu-P17-087 with its albumin binding derivative [177Lu]Lu-P17-088 in metastatic castration-resistant prostate cancer patients: a first-in-human study
“`html Study on PSMA-Targeting Radionuclide Therapy for Prostate Cancer Purpose: Assess PSMA-targeting radionuclide therapy for prostate cancer Evaluate dosimetry and radiation toxicity Explore PSA response in metastatic castration-resistant prostate cancer (mCRPC) patients Methods: Patients with PSMA-positive tumors enrolled after PET/CT scan Five patients received [177Lu]Lu-P17-087 and four received [177Lu]Lu-P17-088 Imaging and dosimetry evaluations were performed […] ➡️➡️➡️
