Clinical trials

“`html Human Herpes Virus-6 (HHV-6) Reactivation after Hematopoietic Cell Transplant and Chimeric Antigen Receptor (CAR)- T Cell Therapy: A Shifting Landscape Key Points: HHV-6B reactivation affects about half of HCT recipients and can lead to various complications. ciHHV6, a persistent form of HHV-6, can complicate diagnosis and is associated with adverse outcomes. Recent changes in […] ➡️➡️➡️

“`html Case Report: Long-Term Survival of a Patient with Cerebral Metastasized Ovarian Carcinoma Treatment with Personalized Peptide Vaccine and Anti-PD-1 Therapy Ovarian cancer is a common and deadly cancer among women, especially in advanced stages. A 49-year-old patient with stage III ovarian cancer received a personalized peptide vaccine and anti-PD-1 therapy after standard treatments failed. […] ➡️➡️➡️

“`html Evaluation of a FlpA Glycoconjugate Vaccine to Reduce Campylobacter jejuni Colonisation in Chickens Published in Vaccines (Basel) on April 9, 2024 Campylobacter is a common cause of stomach illness in humans, often linked to eating poultry. This study aimed to test a vaccine to reduce Campylobacter in chickens, which could lower the risk of […] ➡️➡️➡️

Advancing Postoperative Pain Management in Oral Cancer Patients: A Systematic Review Practical Solutions and Value The review explores postoperative pain management in oral cancer patients using a systematic approach. Highlights the practical solutions of persistent opioid use and the efficacy of adjuvant drugs, such as gabapentin. Emphasizes the value of a multimodal approach and personalized […] ➡️➡️➡️

“`html Practical Solutions and Value of Budesonide in Asthma Treatment Key Points: Inhaled corticosteroids (ICSs) revolutionized the treatment of mild-to-moderate asthma by focusing on reducing inflammation in the airways. Budesonide (BUD) offers a unique clinical profile due to its alternative kinetics, providing practical solutions for effective asthma management. Its high water solubility allows for rapid […] ➡️➡️➡️

Document Nucleoside Reverse Transcriptase Inhibitor Exposure and Alzheimer’s Disease Risk In a recent study published in Pharmaceuticals (Basel), it was found that exposure to nucleoside reverse transcriptase inhibitors (NRTIs) may be linked to a lower risk of Alzheimer’s disease (AD). This study was conducted as a retrospective cohort proof-of-concept and aimed to evaluate the incidence […] ➡️➡️➡️

“`html 68Ga-DOTA-D-Alanine-BoroPro Radiotracer for Imaging of the Fibroblast Activation Protein in Malignant and Non-Malignant Diseases Summary A new radiotracer, 68Ga-iFAP, has been developed for PET imaging to detect fibroblast activation protein (FAP) in tumors and non-malignant tissues. The radiotracer showed high specificity for FAP and provided clear visualization of glioblastoma, breast tumor, prostate cancer, and […] ➡️➡️➡️

“`html Beneficial Effect of Heat-Killed Lactic Acid Bacterium Lactobacillus johnsonii No. 1088 A randomized, placebo-controlled, double-blind, parallel-group clinical study was conducted to examine the effects of ingesting a heat-killed lactic acid bacterium, Lactobacillus johnsonii No. 1088 (LJ88) on temporal gastroesophageal reflux-related symptoms in healthy volunteers. A total of 120 healthy Japanese volunteers of both sexes, […] ➡️➡️➡️

“`html Study Title The Association between Circulating Cytokines and Body Composition in Frail Patients with Cardiovascular Disease Key Findings Frail patients have significantly reduced fat-free mass and a higher prevalence of diabetes. Several cytokines, including FGF basic and follistatin, showed associations with frailty. Multiple cytokines were found to correlate with fat-free mass, a key indicator […] ➡️➡️➡️

“`html Association between Homocysteine and Vitamin D Levels in Asymptomatic Korean Adults Summary An increased homocysteine level is a risk factor for cardiovascular disease, venous thromboembolism, cerebrovascular disease, and chronic kidney disease. Vitamin D deficiency is associated with coronary artery disease and metabolic disorders. The study included data from 1375 adults (895 men and 480 […] ➡️➡️➡️

Practical Solutions in Managing Glioblastoma Glioblastoma is a very aggressive and common type of brain tumor, which makes life difficult for patients. Their survival rate is usually around 15 months, despite advancements in technology and understanding of the tumors. However, molecular profiling has provided new data to better classify glioblastoma. This includes identifying mutations in […] ➡️➡️➡️

“`html Reproductive Outcomes in Young Women with Early-Stage Cervical Cancer Greater than 2 cm Undergoing Fertility-Sparing Treatment: A Systematic Review Summary Cervical cancer is a significant concern for young women. There is limited information about fertility-sparing treatment for cervical cancers larger than 2 cm. This review aimed to assess the reproductive outcomes of women with […] ➡️➡️➡️

“`html GNB1 Encephalopathy: Clinical Case Report and Literature Review Highlights Rare genetic disease caused by pathogenic variants in the GNB1 gene Only around 68 cases documented worldwide Main symptoms include mild developmental delay, cognitive impairment, dystonia, and nystagmus Diagnosis relies on genetic testing due to low specificity of symptoms No standardized treatment guidelines available Deep […] ➡️➡️➡️

“`html Transitioning to Personalized Care in Small-Cell Lung Cancer (SCLC) International Journal of Molecular Sciences, April 10, 2024 Summary: Lung cancer is a major concern worldwide, especially small-cell lung cancer (SCLC) which grows rapidly and is often diagnosed at an advanced stage. Recent clinical trials have shown that using immune checkpoint inhibitors in first-line chemotherapy […] ➡️➡️➡️

“`html Potential Benefits of Photon-Counting CT in Dental Imaging: A Narrative Review Background/Objectives: Photon-counting computed tomography (PCCT) is a new technology improving dental diagnosis and treatment planning. PCCT offers high resolution, improved soft-tissue contrast, and faster scanning times, essential for detailed dental diagnosis and treatment planning. It uses semiconductor detectors to produce sharper images and […] ➡️➡️➡️

“`html Fluorescence-Guided Laparoscopy for Staging of Gastric Cancer Practical Solutions and Value Hypericin, a fluorescent compound from plants, was tested to improve visualization of peritoneal metastasis (PM) in gastric cancer (GC) through laparoscopy. Study aimed to assess safety and feasibility of oral hypericin and the effectiveness of fluorescence-guided laparoscopy (FGL) for staging GC. Patients received […] ➡️➡️➡️

“`html Exploring the Link between Anticoagulation, Cognitive Impairment and Dementia in Atrial Fibrillation: A Systematic Review Background The review aims to understand how anticoagulants affect cognitive function and dementia in atrial fibrillation patients. Methods SCOPUS and PubMed were searched for English articles on OACs and cognitive impairment/dementia in AF patients. Non-original research and studies without […] ➡️➡️➡️

“`html Neutrophil Extracellular Traps and Respiratory Disease Practical Solutions and Value Neutrophil extracellular traps (NETs) play a crucial role in the initial immune response to infection but can also contribute to tissue damage due to their highly inflammatory nature. NETs are particularly relevant to lung diseases, and their presence has been demonstrated in conditions such […] ➡️➡️➡️

“`html Sonography as a Diagnostic Tool in Midurethral Sling Complications: A Narrative Review Key Points: Midurethral slings (MUS) are a common treatment for stress urinary incontinence (SUI) but can lead to postoperative complications. Sonography is a valuable tool for diagnosing complications from MUS procedures. This review examines the use of pelvic floor ultrasound in identifying […] ➡️➡️➡️

“`html Insights on Corneal Neurotization for Neurotrophic Keratopathy Practical Solutions and Value Neurotrophic keratopathy (NK) results from corneal denervation due to various trigeminal nerve dysfunctions. Modern corneal neurotization (CN) techniques aim to restore corneal sensitivity with less invasive options. Donor nerve selection and preparation are crucial for surgical success and often require multidisciplinary teams. Key […] ➡️➡️➡️