Precision Medicine to Redefine Insulin Secretion and Monogenic Diabetes-Randomized Controlled Trial (PRISM-RCT) in Chinese patients with young-onset diabetes: design, methods and baseline characteristics

Precision Medicine to Redefine Insulin Secretion and Monogenic Diabetes-Randomized Controlled Trial (PRISM-RCT)

Highlights of the Study

We designed a patient-centered care model to evaluate its impact on clinical outcomes in young-onset type 2 diabetes patients.

Research Design and Methods

The trial evaluates a multicomponent care model using technology, biogenetic markers, and patient-reported outcomes in patients diagnosed with type 2 diabetes at a young age.

Results

884 patients were assigned to receive specialist-led team-based management or usual care. The study identified various health profiles and comorbidities among the patients, highlighting the complexity of young-onset diabetes.

Conclusions

The study shows that young-onset diabetes is characterized by complex etiologies with comorbidities including mental illness and lifecourse events.

Trial Registration

Trial registration number: NCT04049149

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