Clinical trials

Real-World Effectiveness of Antibiotic Strategies for Urinary Tract Infection Real-World Effectiveness of Antibiotic Strategies for Urinary Tract Infection Study Overview A study was conducted to compare the effectiveness of different antibiotic treatments for gram-negative bloodstream infection from a complicated urinary tract infection source. Methods Multicenter observational cohort study Comparison of intravenous and oral antibiotic regimens […] ➡️➡️➡️

Asynchronous Video Directly Observed Therapy for Tuberculosis Treatment Practical Solutions and Value Medication adherence for tuberculosis treatment can be monitored effectively and cost-efficiently using self-recorded videos (video directly observed therapy [VDOT]) instead of in-person observation. A randomized controlled trial compared VDOT and clinic-based monitoring for patients with latent tuberculosis infection (LTBI) undergoing a 3-month treatment. […] ➡️➡️➡️

“`html Identifying Time-Resolved Features of Nocturnal Sleep Characteristics of Narcolepsy Using Machine Learning Summary Narcolepsy type 1 is difficult to diagnose due to similar symptoms with other disorders. A machine learning framework was developed to differentiate narcolepsy type 1 nighttime sleep features from other disorders. Polysomnography data from 350 individuals was analyzed to identify distinct […] ➡️➡️➡️

“`html Prophylactic-dose direct oral anticoagulants for non-hospitalised people with COVID-19: A meta-analysis of randomised controlled trials Summary Investigated the impact of prophylactic-dose direct oral anticoagulants (DOACs) in non-hospitalised COVID-19 patients. Compared DOACs with placebo or no treatment in six randomised controlled trials involving 4307 patients. Found that prophylactic-dose DOAC therapy significantly decreased risks of all-cause […] ➡️➡️➡️

“`html Study Title The toxicity of chlorine dioxide to clownfish and its bactericidal capability to pathogenic strains of vibrio spp Abstract Global transportation of ornamental fish can stress fish and cause mortality Clownfish are commonly traded and susceptible to pathogenic strains of vibrio Prophylactic treatment of water or fish is recommended In this study, chlorine […] ➡️➡️➡️

“`html Summary: The Role of Non-Oropharyngeal Biopsies in Head and Neck Squamous Cell Carcinoma of Unknown Primary: A Systematic Review Introduction – This review looks at the use of biopsies in non-oropharyngeal areas for patients with head and neck squamous cell carcinoma of unknown primary (HNSCCUP). Methods – The review followed the Preferred Reporting Items […] ➡️➡️➡️

“`html The revision and factor analytic evaluation of the German version of the depression literacy scale (D-Lit-R German) Abstract Depression is a common mental health disorder and the second leading cause of disability worldwide. Low depression literacy can hinder adequate therapy for depression. The German Depression Literacy Scale (D-Lit) has been revised and evaluated in […] ➡️➡️➡️

“`html Study Summary: Comparing Traditional and Digital Crown Extension Guides for Anterior Teeth Restoration Objective: Compare clinical outcomes of traditional and digital crown extension guides for aesthetic restoration of anterior teeth Analyze differences in results of various digital crown extension guides Methods: 62 patients needing anterior teeth restoration Randomly divided into three groups: control, experimental […] ➡️➡️➡️

“`html Perioperative Right Ventricular Dysfunction: Understanding the Risks and Implications In this edition of the journal, the Perioperative Quality Initiative (POQI) presents three manuscripts focusing on the physiology, assessment, and management of right ventricular dysfunction (RVD) in the perioperative setting. Risk Factors for Perioperative RVD Pre-existing RVD Fluid overload Myocardial ischemia Pulmonary embolism Lung injury […] ➡️➡️➡️

“`html Study Summary: Movement System Impairment-Based Classification for Knee Pain Background: Knee pain is a common issue, and movement impairments can contribute to it. This study aims to compare the effectiveness of a movement system impairment-based treatment with routine physiotherapy for individuals with tibiofemoral rotation syndrome. Methods: 22 individuals with knee pain were included in […] ➡️➡️➡️

“`html Summary of Research on Behavioral Interventions for Autism Background: Behavioral interventions for autism, specifically Naturalistic Developmental Behavior Interventions (NDBIs), have gained popularity as effective treatments. However, there is a lack of research on which NDBI method is most effective for parents and children with autism spectrum disorders. Methods: 32 randomized controlled trial studies were […] ➡️➡️➡️

“`html Study on Timely Management of Acute Disease in Older Adults Practical Solutions and Value Point-of-Care testing, including Focused Lung Ultrasound (FLUS) and in-home analysis of biological material, can help in timely recognition and management of acute respiratory disease in older adults. A non-randomised pilot and feasibility study was conducted to test the study design, […] ➡️➡️➡️

“`html Study Summary Cardiovascular disease is a major cause of death and illness globally, especially in people at high risk. The Hjerteløftet Study showed that a 36-month primary prevention program significantly reduced cardiovascular risk scores. This follow-up study aimed to further explore the program’s effects. Key Findings Physical activity increased significantly in the intervention group […] ➡️➡️➡️

“`html Real-world Evidence Study Shows Positive Experiences with Eptinezumab for Chronic Migraine Background Despite advances in migraine treatment, many patients still face significant burden due to exclusion from traditional trials. This study aimed to understand patients’ and physicians’ real-world experiences with eptinezumab for chronic migraine. Methods Observational, multi-site (n = 4), US-based study Patients ≥ […] ➡️➡️➡️

“`html Study Summary Researchers developed and tested a machine learning algorithm using smartwatches to estimate physical activity intensity. The algorithm categorized activity levels into sedentary, light, moderate, and vigorous based on metabolic equivalent (MET) values. The study involved 24 adults and 18 children. Key Findings For adults, the algorithm showed high accuracy in classifying sedentary, […] ➡️➡️➡️

“`html Predicting Response to rTMS in Patients with Schizophrenia The effectiveness of repetitive transcranial magnetic stimulation (rTMS) as a treatment for schizophrenia varies among patients. This variability can be better understood by using artificial intelligence to analyze MRI, clinical, sociodemographic, and genetic data. We developed and tested rTMS response prediction models in patients with schizophrenia […] ➡️➡️➡️

“`html Summary of Study on Infertility Genes In recent years, there has been a growing identification of genes linked to male and female infertility. This has expanded the scope of genetic analysis beyond karyotypes and specific genes, allowing for the simultaneous analysis of numerous infertility genes. Key Findings: Diagnostic activity over the past two years […] ➡️➡️➡️

“`html Summary of Clinical Trial Findings Purpose Glioblastoma (GBM) treatment limitations due to systemic toxicity and blood-brain barrier (BBB) permeability Use of vascularized flaps to bypass BBB and improve access of immune cells to tumor microenvironment Methods 12 patients with newly diagnosed GBM underwent surgical resection followed by lining of the cavity with autologous TPFF […] ➡️➡️➡️

“`html Summary: Financial Impact of Bevacizumab Treatment for Juvenile-onset Recurrent Respiratory Papillomatosis (JoRRP) Background: JoRRP is a rare and costly condition linked to human papillomavirus, requiring frequent surgical debridement as the standard care. Systemic bevacizumab has shown promising results as an adjunctive therapy. Study Objective: To assess the financial implications of using systemic bevacizumab for […] ➡️➡️➡️

“`html Summary of Clinical Trial Findings Recent research in prostate cancer trials has focused on finding intermediate clinical endpoints (ICEs) that can provide reliable indicators of overall survival (OS). Practical Solutions and Value Metastasis-free survival has been identified as a strong ICE for localized prostate cancer, offering a practical and cost-effective measure for assessing treatment […] ➡️➡️➡️