Clinical trials

“`html Study Overview This study explored whether a one-week reduced-carbohydrate diet (RCD) could help improve insulin sensitivity and endothelial function in adults with type 1 diabetes. The researchers compared the effects of the RCD to a standard carbohydrate diet (SCD). Key Findings The RCD led to a 16% reduction in daily insulin doses. However, insulin […] ➡️➡️➡️

Background In cases where scaphoid fractures are suspected but initial x-rays appear normal, patients are usually put in a cast. However, only 10% of these cases actually have a fracture. To prevent unnecessary treatments, we studied whether using a bandage instead of a cast leads to similar recovery results. Study Overview We conducted a clinical […] ➡️➡️➡️

Study Overview Amniocentesis is a common test during pregnancy to check for genetic conditions. This study looked at how using videos to provide information affects anxiety and pain for women undergoing this procedure. Key Findings The study included women aged 18-45 who were scheduled for amniocentesis. They were divided into two groups: one received video-based […] ➡️➡️➡️

Study Overview This study focused on the effectiveness and safety of Cinnatropin®, a biosimilar growth hormone, in treating growth-related disorders in children and adolescents. Key Findings A total of 20,465 patients participated, with 405 in a detailed analysis. The most common issue was growth hormone deficiency. After 12 months, the average height standard deviation score […] ➡️➡️➡️

Background Many traditional antidepressants work well for some patients but not for everyone, especially those with major depressive disorder (MDD). Agomelatine is a different type of antidepressant that may help enhance the effects of standard treatments like SSRIs and SNRIs. This study looks at how well agomelatine works when added to these traditional medications for […] ➡️➡️➡️

Purpose Pathology reports can be difficult for patients newly diagnosed with breast cancer to understand. We studied how patient-centered pathology reports (PCPRs), which use simpler language, can help patients better understand their results. Methods We involved sixty-six patients who were recently diagnosed with breast cancer. They were divided into two groups: one group received both […] ➡️➡️➡️

Study Overview This study aimed to see if probiotics could help improve behavior and gut issues in children aged 2-9 with autism spectrum disorder (ASD). Study Design The research was a single-blinded, randomized, placebo-controlled trial conducted at five clinics. Participants 180 children with ASD participated, divided into two groups: one received probiotics and the other […] ➡️➡️➡️

Study Overview This study looked at how effective a medication called upadacitinib is for patients with axial spondyloarthritis (axSpA), a type of arthritis that affects the spine. The goal was to see if starting treatment early makes a difference in long-term health outcomes. Study Details Researchers conducted two studies (SELECT-AXIS 1 and 2) involving patients […] ➡️➡️➡️

Background People with dementia often have trouble sleeping. The MoNoPol-Sleep study aimed to create and test a new approach to help improve sleep for those living in nursing homes. Objectives The study looked at how well the new sleep intervention was put into practice, what helped or hindered its use, and how it was accepted […] ➡️➡️➡️

Purpose Pathologists diagnose prostate cancer using special stained slides from needle biopsies. Some labs use expensive tests for every case, which can cost more than what they get paid. This study looked at whether using an AI tool can help reduce these costs while still keeping diagnosis safe. Methods Patients suspected of having prostate cancer […] ➡️➡️➡️

Understanding the Impact of Frailty on Cognitive Health Background: Frailty often occurs alongside dementia, which can affect cognitive abilities. Research has shown that a comprehensive lifestyle change can improve cognitive function. Our study aimed to see if frailty influences the effectiveness of these lifestyle changes. Study Overview The Finnish Geriatric Intervention Study (FINGER) included 1,259 […] ➡️➡️➡️

Purpose Women taking aromatase inhibitors (AIs) for breast cancer often suffer from joint pain, stiffness, and muscle weakness. This study looked at whether aerobic exercise can help reduce these symptoms. Methods In this study, 136 postmenopausal women with breast cancer were divided into two groups: one group did moderate-intensity aerobic exercise for 6 months, while […] ➡️➡️➡️

Purpose Understanding how nutrition affects health in people with metabolic issues is difficult. We need sensitive tools to measure this. A new method called phenotypic flexibility helps us see how the body responds to challenges. A special biomarker has been useful in studying the health benefits of whole-grain wheat for overweight and obese individuals. We […] ➡️➡️➡️

“`html Objective This research looked at how different types of hemodialysis, when combined with low-calcium dialysate (LCD), affect mineral balance and blood vessel hardening in patients with chronic kidney disease (CKD) who are on maintenance hemodialysis (MHD). Methods Data was gathered from 192 MHD patients, who were divided into four groups. Each group received LCD […] ➡️➡️➡️

Introduction Sexual minority women face high risks of dangerous drinking and mental health issues like depression and anxiety. Research shows that stress from societal stigma affects their drinking habits and mental well-being. However, no effective treatments have been tested specifically for this group. This article introduces Project EQuIP, a study designed to test a special […] ➡️➡️➡️

Introduction Chemotherapy can cause serious side effects, especially damage to the digestive system, known as gastrointestinal mucositis (GI-M). This can lead to problems like diarrhea, weight loss, pain, fatigue, and sleep issues. Managing these symptoms often requires multiple medications, which can be risky. The CANCAN trial explores how medicinal cannabis might help reduce these side […] ➡️➡️➡️

Summary of Research on Exercise and Decision Making This study explored how short sessions of aerobic exercise impact risky decision making and reward processing in young adults. Key Findings Researchers looked at 60 participants, both male and female, who either exercised for 20 minutes on a treadmill or watched a video. They tested decision-making skills […] ➡️➡️➡️

“`html Background Quick diagnosis is essential for treating acute spinal cord injuries (SCI). We believe that a special blood test can help diagnose SCI, measure how serious the injury is, and predict long-term recovery. Methods We developed a blood test that looks for specific DNA markers in the blood of patients with acute SCI. We […] ➡️➡️➡️

Key Findings from the PhALLCON Study In March 2024, the FDA approved ponatinib for treating newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph + ALL) alongside chemotherapy. This decision was based on the Phase 3 PhALLCON study, which showed that ponatinib resulted in a better chance of achieving remission without detectable cancer cells compared to […] ➡️➡️➡️

Study Overview The research focuses on a treatment called Chlorophyllin (CHL) for patients suffering from brain radionecrosis due to diffuse glioma. This study shows that CHL may help reduce the negative effects of radiation therapy. Study Details This is a phase 2 clinical trial involving adults over 18 years old with diffuse glioma experiencing radionecrosis. […] ➡️➡️➡️