Clinical trials
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseDrug Development
Drug Development Overview Background Patients with Alzheimer’s disease (AD) often face challenging neuropsychiatric symptoms, like agitation. This can lead to increased stress for caregivers and more placements in long-term care facilities. AXS-05, a new drug combining dextromethorphan and bupropion, is being studied for treating AD agitation (ADA). It is already FDA-approved for major depressive disorder. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseDrug Development
Drug Development LatAm-FINGERS Trial Overview The LatAm-FINGERS trial is a groundbreaking clinical study involving participants from 12 Latin American countries. This trial focuses on providing inclusive and diverse recruitment, especially for underserved populations. Methodology This trial is a multicenter randomized study that assesses a lifestyle intervention designed for the Latin American community. Key features include: […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseDrug Development
Drug Development in Alzheimer’s Disease Trials Background In Alzheimer’s Disease (AD) trials, we use clinical scales to measure how well treatments work. To improve the accuracy of trial results, we can use machine learning to create AI-generated digital twins. These digital twins give us personalized predictions of how a patient’s condition might change if they […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseDrug Development
Drug Development Study Overview This clinical trial examined the use of transcutaneous vagus nerve stimulation (tVNS) to help improve memory and cognitive function in participants with mild cognitive impairment (MCI). Trial Details The study had a randomized, double-blind, placebo-controlled crossover design. A total of 59 participants with MCI were divided into two groups: one received […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseDrug Development
Drug Development Study Overview The study titled “Acute Exercise Response on Brain Imaging and Cognition (AEROBIC)” investigates how aerobic exercise affects brain health in older adults. It includes both cognitively healthy and impaired individuals aged 60 and above. Key Findings Exercise Benefits: Aerobic exercise significantly improves brain metabolism, as shown by changes in glucose levels […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseDementia Care Research and Psychosocial Factors
Dementia Care Research and Psychosocial Factors Study Overview This study, published in Alzheimers Dement, focuses on improving dementia awareness and reducing stigma among healthcare workers and the public. Background Many people lack knowledge about dementia, leading to stigma and discrimination. To combat this, we need effective interventions that are based on evidence. Methodology We conducted […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Technology and Dementia Preconference
Technology and Dementia Preconference Background Alzheimer’s disease (AD) is a major global health issue that requires new treatment methods. Recent advancements in medical devices using biophoton technology have shown promise in enhancing the cognitive abilities and quality of life for AD patients. Method This study was a randomized, triple-blinded, placebo-controlled clinical trial aimed at determining […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
The newborn behavioural observations (NBO) system embedded in routine postpartum care in at-risk families in Iceland: a randomised controlled trial
The Newborn Behaviour Observation (NBO) System: A Study in Iceland Study Overview The Newborn Behaviour Observation system (NBO) is a helpful tool for parents to understand their newborns better. This study aimed to see how this system affects mothers’ confidence in the first month after giving birth and the quality of interactions between mothers and […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe effect of hand and foot exercises on peripheral neuropathy and quality of life in women with breast cancer: a randomized controlled trial
The Impact of Hand and Foot Exercises on Women with Breast Cancer Study Overview This study investigates how hand and foot exercises influence peripheral neuropathy and overall quality of life in women undergoing chemotherapy for breast cancer. Importance of the Study Peripheral neuropathy can greatly affect patients’ lives. This research aims to identify supportive care […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseDifferent daily times for at-home bleaching with 10% carbamide peroxide: A randomized single-blind, noninferiority controlled trial
Study on At-Home Teeth Bleaching with 10% Carbamide Peroxide Background This study tested if using 10% carbamide peroxide (CP) for 2 or 4 hours daily is as effective as using it for 8 hours daily. Methods A total of 120 healthy adults with teeth shades A2 or darker participated. They were divided into three groups […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseTesting the Recruitment Frequency, Implementation Fidelity, and Feasibility of Outcomes of the Heart Failure Activity Coach Study (HEALTHY): Pilot Randomized Controlled Trial
Testing the Heart Failure Activity Coach Study (HEALTHY) Background Heart failure (HF) is a serious condition linked to a lack of physical activity. While many patients survive their first year after diagnosis, being inactive can lead to higher mortality rates and lower quality of life. Objective This study aimed to evaluate how well we could […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePatient experience with eosinophilic esophagitis symptoms and impacts on daily life based on in-trial qualitative interviews
Understanding Patient Experiences with Eosinophilic Esophagitis (EoE) Purpose of the Study Eosinophilic esophagitis (EoE) is a long-term immune-related disease that causes symptoms like: Difficulty swallowing (dysphagia) Food getting stuck Abdominal pain Vomiting Heartburn This condition can significantly lower quality of life due to its physical and emotional effects. This study aimed to gather insights from […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAcute hypoalgesic and neurophysiological responses to lower-limb ischaemic preconditioning
Acute Hypoalgesic and Neurophysiological Responses to Lower-Limb Ischaemic Preconditioning Study Overview This study aimed to find out if ischaemic preconditioning (IPC) can help reduce pain and improve muscle response during voluntary movements. Healthy participants took part in three sessions after getting familiar with the procedures. Key Findings Pain Threshold Improvement: After IPC, the pressure pain […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Study protocol for key interventions to improve the follow-up adherence postcervical precancerous lesion treatment in Ethiopia: a pragmatic randomised controlled trial
Study Overview This study focuses on improving follow-up care for women treated for cervical precancerous lesions in Ethiopia. Follow-up care is essential to prevent cervical cancer, but many women do not return for necessary check-ups. Our goal is to find effective strategies to encourage these women to adhere to follow-up recommendations. Key Interventions We will […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy of delivery of care with Tele-continuous EEG in critically ill patients: a multicenter randomized controlled trial (Tele-cRCT study) study
Efficacy of Tele-EEG in Critically Ill Patients Study Overview This study looked at the effectiveness of Tele-continuous EEG (Tele-cEEG) compared to Tele-routine EEG (Tele-rEEG) for critically ill patients. The main focus was on seizure detection, mortality rates, and functional outcomes. Study Details The research took place over three years in eight hospitals in Thailand. It […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase«Ashamed of being seen in an HIV clinic»: a qualitative analysis of barriers to engaging in HIV care from the perspectives of patients and healthcare workers in the Daraja clinical trial
Barriers to Engaging in HIV Care: Insights from the Daraja Clinical Trial Background Many people with HIV face high risks after leaving the hospital. Their survival rates improve significantly when they start attending HIV clinics early and stick to their treatment plans. The Daraja intervention, a tailored management strategy tested in Tanzania, showed positive results […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Short-term WB-EMS in Cancer Patients: Positive Effects After 2 Weeks of Exercise-A Single-arm Trial
Short-term WB-EMS in Cancer Patients: Positive Effects After 2 Weeks of Exercise Study Overview This study examined the use of short-term Whole-body electromyostimulation (WB-EMS) for cancer patients who often struggle with intense exercise due to treatment side effects. The goal was to see if WB-EMS training could be effective and practical. Methodology Thirteen cancer patients […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Assessment of correlation between the Modified Schirmer Test and unstimulated salivary flow testing
Study on Salivary Flow Tests Purpose: This study aimed to compare the Modified Schirmer Test (MST) with the traditional Unstimulated Salivary Flow Test (USFT) for measuring saliva production in patients with dry mouth. Methods: We enrolled 100 participants, some with dry mouth and some without. Each participant completed a short survey about their dry mouth […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffect of timing of antibiotic use on premature rupture of membranes and its impact on reproductive tract infection and fetal membrane cell scorching indicators
Study Overview This study looked at how the timing of antibiotic use affects infections and cell damage in pregnant women with premature rupture of membranes (PROM). Key Findings Participants: 107 pregnant women with PROM were divided into two groups. Intervention Group: 54 women received ampicillin within 24 hours of PROM. Control Group: 53 women received […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseComparing the Effects of Collagen Hydrolysate and Dairy Protein on Recovery from Eccentric Exercise: A Double Blind, Placebo-Controlled Study
Study on Collagen Hydrolysate vs. Dairy Protein for Muscle Recovery Background This study looks at whether collagen hydrolysate (CH) can help with muscle recovery after exercise better than dairy protein (DP), which is a common protein supplement. Methods A total of 33 males participated in the study. They were divided into three groups: Group 1: […] ➡️➡️➡️