Clinical trials
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseFrequency of red blood cell allo-immunization in patients undergoing blood transfusion at the Uganda Cancer Institute
Frequency of Red Blood Cell Allo-Immunization in Patients Undergoing Blood Transfusion at the Uganda Cancer Institute ABSTRACT There is limited data on red blood cell (RBC) alloimmunization in patients with cancer in sub-Saharan Africa (SSA). We examined the frequency of RBC alloimmunization in transfused patients with cancers in Uganda. METHODS A randomized control trial was […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEtomidate Combined with Propofol versus Remimazolam for Sedation in Elderly Patients During Gastrointestinal Endoscopy: A Randomized Prospective Clinical Trial
Study Summary Comparison of Sedation Drugs in Elderly Patients During Gastrointestinal Endoscopy Researchers compared the use of remimazolam besylate and a combination of etomidate and propofol for sedation in elderly patients undergoing gastrointestinal endoscopy. The study aimed to assess the effectiveness and safety of these sedation methods. Key Findings Remimazolam besylate showed comparable safety and […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA phase I thorough QT/QTc study evaluating therapeutic and supratherapeutic doses of avacopan in healthy participants
Phase I Thorough QT/QTc Study of Avacopan in Healthy Participants Study Details A phase I thorough QTc study evaluated avacopan’s effect on cardiac repolarization in healthy participants. The study included both therapeutic and supratherapeutic doses of avacopan, as well as placebo and positive controls. Key Findings The study found that avacopan did not have a […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseDigital technology revolutionizing mandibular fracture treatment: a comparative analysis of patient-specific plates and conventional titanium plates
Digital Technology Revolutionizing Mandibular Fracture Treatment Comparative Analysis of Patient-Specific Plates and Conventional Titanium Plates Objective: To assess the clinical effectiveness of patient-specific plates utilizing digital technology in treating mandibular fractures compared to conventional titanium plates. Materials and Methods: Twenty patients with mandibular fractures were included and randomly assigned to study or control groups. The […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffects of the discontinuation of antihypertensive treatment on neuropsychiatric symptoms and quality of life in nursing home residents with dementia (DANTON): a multicentre, open-label, blinded-outcome, randomised controlled trial
Effects of Discontinuing Antihypertensive Treatment in Nursing Home Residents with Dementia Key Findings Discontinuing antihypertensive treatment in nursing home residents with dementia did not significantly reduce neuropsychiatric symptoms or improve quality of life compared to usual care. Study Details The study involved 205 participants with moderate-to-severe dementia and systolic blood pressure ≤160 mmHg. They were […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffect of metformin on gut microbiota imbalance in patients with T2DM, and the value of probiotic supplementation
Effect of Metformin on Gut Microbiota Imbalance in T2DM Patients and the Value of Probiotic Supplementation ABSTRACT PURPOSE: This study aimed to investigate the impact of metformin on gut microbiota imbalance in patients with type 2 diabetes mellitus (T2DM) and the potential benefits of probiotic supplementation. METHODS: 84 newly diagnosed T2DM patients were randomly assigned […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseClinical efficacy and safety of transvaginal natural orifice transluminal endoscopic surgery for benign adnexal disease: a prospective trial
Clinical Trial Results: Transvaginal Natural Orifice Transluminal Endoscopic Surgery for Ovarian Cysts Key Findings The study aimed to assess the safety and feasibility of using transvaginal natural orifice transluminal endoscopic surgery (vNOTES) for managing ovarian cysts. The results showed that vNOTES was not inferior to conventional laparoscopy (CL) in terms of adnexectomy or ovarian cystectomy. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseParticipants’ perspectives of being recruited into a randomised trial of a weight loss intervention before colorectal cancer surgery: a qualitative interview study
Participants’ Perspectives on Weight Loss Intervention Trial Before Colorectal Cancer Surgery Key Findings Patients with excess weight awaiting colorectal cancer surgery were motivated by the offer of structured weight loss support that could potentially improve their surgical outcomes. However, concerns about the potential unpalatability of the intervention diet and side effects were also expressed. Positive […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseMaintenance therapy with anlotinib after induction therapy with platinum-based chemotherapy for advanced non-small-cell lung cancer: A pooled analysis of 2 single-arm trials
Maintenance Therapy with Anlotinib for Advanced Non-Small-Cell Lung Cancer Key Findings Maintenance therapy with anlotinib after platinum-based chemotherapy showed a median progression-free survival of 5.95 months and a median overall survival of 18.60 months in patients with advanced non-small cell lung cancer. Results Out of 23 patients, 19 had stable disease, 1 had a partial […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffectiveness of HIV self-testing when offered within assisted partner services in Western Kenya (APS-HIVST Study): a cluster randomized controlled trial
Effectiveness of HIV Self-Testing in Assisted Partner Services (APS-HIVST Study) Practical Solutions and Value Assisted partner services (APS) is a successful strategy for increasing HIV testing, new diagnoses, and linkage to care among partners of people living with HIV (PLWH). However, it can be resource intensive. This study aimed to assess the effectiveness of offering […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseBronchoscopy with and without needle-based confocal laser endomicroscopy for peripheral lung nodule diagnosis: protocol for a multicentre randomised controlled trial (CLEVER trial)
Bronchoscopy with and without Needle-Based Confocal Laser Endomicroscopy for Peripheral Lung Nodule Diagnosis: Protocol for a Multicentre Randomised Controlled Trial (CLEVER Trial) Introduction Despite technological advances, bronchoscopic peripheral lung nodule analysis still faces limitations due to frequent mispositioning. Needle-based confocal laser endomicroscopy (nCLE) provides real-time microscopic feedback on needle positioning, potentially improving sampling location and […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseHAP-FAST: a feasibility study incorporating qualitative, mechanistic and costing sub-studies alongside a randomised pilot trial comparing chest x-ray to low-dose CT scan and empirical antibiotics to antibiotics guided by the BIOFIRE FILM ARRAY pneumonia plus panel in adults with suspected non-ventilator-associated hospital-cquired pneumonia
HAP-FAST Feasibility Study Key Points: • Evaluating the clinical impact of low-dose CT scans and rapid molecular sputum analysis for suspected non-ventilator-associated hospital-acquired pneumonia (nv-HAP). • Incorporating a pilot trial, qualitative study, costing analysis, and immune-pathophysiology investigation. • Participants recruited from four acute hospitals in the Northwest of the UK. • Assessing trial processes, outcome […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseComparing autologous blood, corticosteroid, and a combined injection of both for treating lateral epicondylitis: a randomized clinical trial
Comparing Autologous Blood, Corticosteroid, and Combined Injection for Lateral Epicondylitis Treatment Background Lateral epicondylitis is a common forearm condition, and this study compared the effectiveness of autologous blood (AB) injection, corticosteroid (CS) injection, and a combined injection of both in treating the condition. Materials and Methods 120 patients were divided into three groups for different […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phasePredictive values of pre-treatment brain age models to rTMS effects in neurocognitive disorder with depression: Secondary analysis of a randomised sham-controlled clinical trial
Predictive Values of Pre-treatment Brain Age Models to rTMS Effects in Neurocognitive Disorder with Depression Introduction Developing personalized repetitive transcranial magnetic stimulation (rTMS) faces challenges due to high inter-individual treatment response variations. Brain morphometry may contribute to these variations. This study aimed to determine if an individual’s brain morphometry could predict rTMS responders and remitters. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA mixed methods process evaluation: understanding the implementation and delivery of HIV prevention services integrated within sexual reproductive health (SRH) with or without peer support amongst adolescents and young adults in rural KwaZulu-Natal, South Africa
Study Title: A mixed methods process evaluation of HIV prevention services in rural South Africa Background Combination prevention interventions integrated with community-based support have shown to benefit adolescent and young people’s sexual and reproductive health. The trial aimed to evaluate the delivery of HIV prevention and care among young people through integrated HIV and sexual […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Comparison of different types of ultrasound probes for lung ultrasound in neonates-A prospective randomized comparison study
Comparison of Ultrasound Probes for Lung Ultrasound in Neonates Key Findings: Study compared different ultrasound probes for lung ultrasound in neonates. Lower NPLUS scores with echo and microconvex probes compared to linear probe. Strong correlation between pulse oximetric saturation/fraction of inspired oxygen ratio and NPLUS score using microconvex probe. Practical Solutions and Value: Results confirm […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseDetermining the optimal frequency of SARS-CoV-2 regular asymptomatic testing: A randomized feasibility trial in a home care setting
Determining the optimal frequency of SARS-CoV-2 regular asymptomatic testing: A randomized feasibility trial in a home care setting Background The SARS-CoV-2 pandemic has posed challenges for caregivers in home care settings, as they can transmit the virus to their high-risk relatives. Regular asymptomatic testing of caregivers may help reduce transmission, but the best testing frequency […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseWeb-Based Cognitive Behavioral Treatment for Bulimia Nervosa: A Randomized Clinical Trial
Web-Based Cognitive Behavioral Treatment for Bulimia Nervosa: A Randomized Clinical Trial Practical Solutions and Value Despite effective treatments for bulimia nervosa (BN), many individuals do not receive evidence-based therapies. Integrating digital interventions into routine care can reach more patients and reduce the clinical burden of BN. A web-based cognitive behavioral self-help intervention was evaluated for […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Prediction of Long-Term Treatment Outcomes for Diabetic Macular Edema Using a Generative Adversarial Network
Prediction of Long-Term Treatment Outcomes for Diabetic Macular Edema Using a Generative Adversarial Network ABSTRACT The study aimed to use generative adversarial networks (GANs) to analyze optical coherence tomography (OCT) images for predicting diabetic macular edema outcomes after long-term treatment. METHODS Diabetic macular edema (DME) eyes (n = 327) from a randomized controlled trial underwent […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCan Biomarkers Correctly Predict Ventilator-associated Pneumonia in Patients Treated With Targeted Temperature Management After Cardiac Arrest? An Exploratory Study of the Multicenter Randomized Antibiotic (ANTHARTIC) Study
Can Biomarkers Predict Ventilator-associated Pneumonia in Patients After Cardiac Arrest? Summary Ventilator-associated pneumonia (VAP) is a common complication after cardiac arrest, but diagnosing it accurately remains a challenge. This study aimed to evaluate the usefulness of biomarkers in diagnosing VAP in post-cardiac arrest patients. Study Design This study was part of the ANTHARTIC trial, a […] ➡️➡️➡️