Clinical trials
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseThe effect of educational intervention based on health belief model on colorectal cancer screening behaviors
The effect of educational intervention based on health belief model on colorectal cancer screening behaviors BMC Public Health. 2024 Jun 19;24(1):1640. doi: 10.1186/s12889-024-19180-8. Summary: This study aimed to assess the impact of an educational intervention based on the health belief model (HBM) on colorectal cancer screening behaviors in individuals aged 50 and above. Methods: 134 […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseWeb-Based, Human-Guided, or Computer-Guided Transdiagnostic Cognitive Behavioral Therapy in University Students With Anxiety and Depression: Randomized Controlled Trial
Web-Based, Human-Guided, or Computer-Guided Transdiagnostic Cognitive Behavioral Therapy in University Students With Anxiety and Depression: Randomized Controlled Trial Key Findings: Web-based interventions were marginally more effective than usual care over 6 months. All groups showed significant improvement in depression and anxiety symptoms over time. Participants in the human-guided condition attended more sessions than those in […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseA Randomized, Double-Blind, Placebo-Controlled Clinical Trial on the Effect of a Dietary Supplement Containing Dry Artichoke and Bergamot Extracts on Metabolic and Vascular Risk Factors in Individuals with Suboptimal Cholesterol Levels
A Randomized, Double-Blind, Placebo-Controlled Clinical Trial on the Effect of a Dietary Supplement Containing Dry Artichoke and Bergamot Extracts on Metabolic and Vascular Risk Factors in Individuals with Suboptimal Cholesterol Levels Key Findings The study found that a dietary supplement containing dry extracts of bergamot and artichoke significantly improved serum lipid concentration and insulin sensitivity, […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy and underlying mechanisms of three-circle post standing qigong on insomnia in college students: a four-arm, double-blind, randomized controlled trial protocol
Efficacy and Mechanisms of TCPS Qigong for Insomnia in College Students Protocol for a Double-Blind, Randomized Controlled Trial Background: Insomnia in college students is often overlooked despite its impact on health and wellbeing. Improving sleep quality through targeted interventions can reduce the risk of related health issues. Qigong exercises, specifically Three-circle Post Standing (TCPS), have […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy and safety of eliapixant in endometriosis-associated pelvic pain: the randomized, placebo-controlled phase 2b SCHUMANN study
Efficacy and Safety of Eliapixant in Endometriosis-Associated Pelvic Pain: The SCHUMANN Study Published in BMC Women’s Health, June 19, 2024 Background: The SCHUMANN study assessed the effectiveness and safety of eliapixant in treating endometriosis-associated pelvic pain (EAPP). Methods: This was a phase 2b study involving women with surgically diagnosed endometriosis and EAPP. Participants were randomly […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseFunctioning and quality of life among treatment-engaged adults with psychotic disorders in urban Tanzania: Baseline results from the KUPAA clinical trial
Functioning and Quality of Life Among Adults with Psychotic Disorders in Tanzania: KUPAA Clinical Trial Key Findings and Implications Understanding the functioning and quality of life of individuals with psychotic disorders is essential for informing policies and programs in low-resource settings like urban Tanzania. Results from the KUPAA clinical trial revealed that higher disability was […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseMicrovascular recovery with ultrasound in myocardial infarction post-PCI trial
Microvascular Recovery with Ultrasound in Myocardial Infarction Post-PCI Trial Abstract Purpose: This study aimed to assess the effectiveness of post-PCI sonothrombolysis in patients with acute anterior wall STEMI. Methods: A randomized controlled trial was conducted on 50 patients who underwent continuous microbubble infusion following successful PCI. Sonothrombolysis was applied in the treatment group. MRI was […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEfficacy and Neural Mechanisms of Mindfulness Meditation Among Adults With Internet Gaming Disorder: A Randomized Clinical Trial
Efficacy and Neural Mechanisms of Mindfulness Meditation Among Adults With Internet Gaming Disorder: A Randomized Clinical Trial Overview The study aimed to assess the effectiveness of mindfulness meditation (MM) in treating internet gaming disorder (IGD) and to identify the neural mechanisms behind MM treatment. Key Findings MM was more effective than progressive muscle relaxation (PMR) […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseComparative Effectiveness of Personal Sound Amplification Products Versus Hearing Aids for Unilateral Hearing Loss: A Prospective Randomized Crossover Trial
Comparative Effectiveness of Personal Sound Amplification Products Versus Hearing Aids for Unilateral Hearing Loss: A Prospective Randomized Crossover Trial ABSTRACT This study compared the effectiveness of personal sound amplification products (PSAPs) and hearing aids (HAs) for individuals with moderate to moderately severe unilateral hearing loss. Thirty-nine participants were randomly assigned to use either a basic […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCost-effectiveness of talazoparib for patients with germline BRCA1/2 mutated HER2-negative advanced breast cancer in China and the US
Cost-effectiveness of Talazoparib for Advanced Breast Cancer Key Findings: Talazoparib, a targeted PARP inhibitor, has shown significant extension in progression-free survival and improved response markers for patients with germline BRCA1/2 mutated HER2-negative advanced breast cancer, compared to conventional therapies. Practical Solutions: Our analysis aims to assess the cost-effectiveness of talazoparib in treating advanced breast cancer […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Lateral episiotomy or no episiotomy in vacuum assisted delivery in nulliparous women (EVA): multicentre, open label, randomised controlled trial
Lateral Episiotomy in Vacuum Assisted Delivery for First-Time Mothers Objective To compare the effect of lateral episiotomy versus no episiotomy on obstetric anal sphincter injury in first-time mothers requiring vacuum extraction. Study Design A multicentre, open label, randomised controlled trial conducted in eight hospitals in Sweden from 2017 to 2023. Participants 717 first-time mothers with […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAssessing the impact of jail-initiated medication for opioid use disorder: A multisite analysis of the SOMATICS collaborative
Assessing the Impact of Jail-Initiated Medication for Opioid Use Disorder: A Multisite Analysis of the SOMATICS Collaborative Objective The objective of this study was to assess the effects of jail-initiated medication for opioid use disorder (MOUD) and patient navigation (PN) on opioid use disorder (OUD) at 6 months post-release. Study Details Three randomized trials (combined […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCost-effectiveness analysis of bevacizumab combined with lomustine in the treatment of progressive glioblastoma using a Markov model simulation analysis
Cost-Effectiveness Analysis of Bevacizumab Combined with Lomustine in the Treatment of Progressive Glioblastoma Key Findings Compared to Lomustine alone, the combination of Bevacizumab and Lomustine increased the total treatment cost from $2,646.70 to $23,650.98. The health-adjusted life years (QALYs) for the combination therapy increased from 0.26 QALYs to 0.51 QALYs, representing an increment of 0.25 […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseCharacterization of anti-drug antibody responses to the T-cell engaging bispecific antibody cibisatamab to understand the impact on exposure
Characterization of Anti-Drug Antibody Responses to Cibisatamab Practical Solutions and Value An appropriately designed pharmacokinetic (PK) assay sensitive for anti-drug antibody (ADA) impact on exposure is an alternative strategy to understand the neutralizing potential of ADAs. The PK assay of cibisatamab, a T-cell-engaging bispecific antibody, was developed based on its mechanism of action (MoA). Using […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseShort-term effects of gastric bypass versus sleeve gastrectomy on high LDL cholesterol: The BASALTO randomized clinical trial
Short-term effects of gastric bypass versus sleeve gastrectomy on high LDL cholesterol: The BASALTO randomized clinical trial ABSTRACT There has been a substantial increase in the use of laparoscopic sleeve gastrectomy (SG) to treat morbid obesity despite observational evidence demonstrating the superiority of Roux-en-Y gastric bypass (RYGB) for reducing low-density lipoprotein (LDL) cholesterol. The main […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Effectiveness of fractional erbium-YAG laser, microneedling, platelet-rich plasma in localized stable vitiligo patients: randomized clinical trial
Effectiveness of Fractional Erbium-YAG Laser, Microneedling, Platelet-Rich Plasma in Localized Stable Vitiligo Patients: Randomized Clinical Trial ABSTRACT Vitiligo is a challenging autoimmune disease to treat. This study compared the effects of fractional erbium:yttrium-aluminum-garnet (Er:YAG) laser-assisted delivery of platelet-rich plasma with microneedling (Mn) and platelet-rich plasma (PRP) in enhancing skin repigmentation in localized stable vitiligo patients. […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseAn online, two-day educational seminar had no impact on disease-specific knowledge in patients with systemic sclerosis
Study Results: Impact of Online Educational Seminar on Systemic Sclerosis Patients Key Findings: An online, two-day educational seminar showed a small increase in disease-specific knowledge among systemic sclerosis (SSc) patients. The seminar resulted in a measurable, but not statistically significant, increase in knowledge. Being a member of a self-help group was found to be a […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Effectiveness of a novel diet in attenuation of clinical activity of disease in patients with ulcerative colitis: a randomized, clinical trial
Effectiveness of a Novel Diet in Ulcerative Colitis Patients Key Findings: A combined Mediterranean, low-FODMAP diet with partial enteral nutrition (PEN) significantly reduced disease activity index and improved quality of life in patients with ulcerative colitis (UC). The diet also led to a significant decrease in serum level of high sensitive C-reactive protein (hs-CRP) and […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phaseEffects of routine physical therapy with and without kinesio taping in improving gross motor function in sitting and standing in spastic diplegic cerebral palsy children
Effects of Routine Physical Therapy with and without Kinesio Taping in Improving Gross Motor Function in Spastic Diplegic Cerebral Palsy Children Objective To determine the effectiveness of Kinesio taping along with routine physical therapy on improving gross motor function in sitting and standing among spastic diplegic Cerebral Palsy children. Design Randomized controlled trial. Participants 53 […] ➡️➡️➡️
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Adverse effects, Clinical outcomes, Clinical research, Clinical study, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Efficacy and safety of 0.01% atropine combined with orthokeratology lens in delaying juvenile myopia: An observational study
Efficacy and Safety of Atropine and Orthokeratology Lens in Delaying Juvenile Myopia Key Findings: A study investigated the effectiveness and safety of combining low-concentration Atropine with orthokeratology (OK) lens in delaying juvenile myopia. The study included 172 adolescents aged 8 to 12 years over a period from April 2021 to May 2022. The results showed […] ➡️➡️➡️